{"title":"调查甘油三酯-葡萄糖指数与慢性肾脏疾病风险之间的关系：一项系统综述和荟萃分析","authors":"Mohammad Sharifi, Fatemeh Maleki Sedgi, Ensiye Soleimani, Houri Heshmatipoor, Mahsa Shirani, Gholamreza Askari","doi":"10.1016/j.clnesp.2025.06.028","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Chronic kidney disease (CKD) has emerged as a critical public health issue, with its global prevalence steadily rising. Insulin resistance has been recognized as a significant contributor to the progression of CKD. The triglyceride-glucose (TyG) index, an established surrogate marker of insulin resistance, has been suggested as a potential predictor for CKD risk. However, the relationship between the TyG index and CKD remains inconsistent across various studies.</p><p><strong>Objective: </strong>This systematic review and meta-analysis aimed to evaluate the association between the TyG index and risk of developing CKD across diverse populations.</p><p><strong>Methods: </strong>A comprehensive literature search was conducted in the PubMed, ISI Web of Science, and Scopus databases through December 2024. Eligible studies examining the association between the TyG index and CKD risk were included. The pooled effect size (ES) was calculated using a random-effects model. Subgroup analyses were conducted based on study design, population characteristics, and methodological quality.</p><p><strong>Results: </strong>A total of 33 observational studies, encompassing 322,394 participants, were included. The meta-analysis revealed a significant association between a higher TyG index and an increased risk of CKD (pooled ES: 1.67; 95% CI: 1.51-1.86, P < 0.001) when analyzed as a categorical variable. A similar significant association was observed when the TyG index was assessed as a continuous variable (pooled ES: 1.44; 95% CI: 1.28-1.62, P < 0.001). Subgroup analyses indicated that this association was consistent across various study designs, geographic regions, and population characteristics.</p><p><strong>Conclusion: </strong>The findings suggest that the TyG index is a reliable predictor of CKD risk and may serve as a valuable tool for the early identification of individuals at high risk. Future research should focus on exploring the underlying mechanisms and evaluating the clinical utility of the TyG index in CKD screening and prevention strategies.</p>","PeriodicalId":10352,"journal":{"name":"Clinical nutrition ESPEN","volume":" ","pages":""},"PeriodicalIF":2.9000,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Investigating the association between Triglyceride-glucose index and risk of chronic kidney disease: A systematic review and meta-analysis.\",\"authors\":\"Mohammad Sharifi, Fatemeh Maleki Sedgi, Ensiye Soleimani, Houri Heshmatipoor, Mahsa Shirani, Gholamreza Askari\",\"doi\":\"10.1016/j.clnesp.2025.06.028\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Chronic kidney disease (CKD) has emerged as a critical public health issue, with its global prevalence steadily rising. Insulin resistance has been recognized as a significant contributor to the progression of CKD. The triglyceride-glucose (TyG) index, an established surrogate marker of insulin resistance, has been suggested as a potential predictor for CKD risk. However, the relationship between the TyG index and CKD remains inconsistent across various studies.</p><p><strong>Objective: </strong>This systematic review and meta-analysis aimed to evaluate the association between the TyG index and risk of developing CKD across diverse populations.</p><p><strong>Methods: </strong>A comprehensive literature search was conducted in the PubMed, ISI Web of Science, and Scopus databases through December 2024. Eligible studies examining the association between the TyG index and CKD risk were included. The pooled effect size (ES) was calculated using a random-effects model. Subgroup analyses were conducted based on study design, population characteristics, and methodological quality.</p><p><strong>Results: </strong>A total of 33 observational studies, encompassing 322,394 participants, were included. The meta-analysis revealed a significant association between a higher TyG index and an increased risk of CKD (pooled ES: 1.67; 95% CI: 1.51-1.86, P < 0.001) when analyzed as a categorical variable. A similar significant association was observed when the TyG index was assessed as a continuous variable (pooled ES: 1.44; 95% CI: 1.28-1.62, P < 0.001). Subgroup analyses indicated that this association was consistent across various study designs, geographic regions, and population characteristics.</p><p><strong>Conclusion: </strong>The findings suggest that the TyG index is a reliable predictor of CKD risk and may serve as a valuable tool for the early identification of individuals at high risk. Future research should focus on exploring the underlying mechanisms and evaluating the clinical utility of the TyG index in CKD screening and prevention strategies.</p>\",\"PeriodicalId\":10352,\"journal\":{\"name\":\"Clinical nutrition ESPEN\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":2.9000,\"publicationDate\":\"2025-06-23\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Clinical nutrition ESPEN\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1016/j.clnesp.2025.06.028\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"NUTRITION & DIETETICS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical nutrition ESPEN","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1016/j.clnesp.2025.06.028","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"NUTRITION & DIETETICS","Score":null,"Total":0}
引用次数: 0
摘要
背景：慢性肾脏疾病（CKD）已成为一个重要的公共卫生问题，其全球患病率稳步上升。胰岛素抵抗已被认为是CKD进展的重要因素。甘油三酯-葡萄糖（TyG）指数是胰岛素抵抗的替代指标，已被认为是CKD风险的潜在预测指标。然而，TyG指数与CKD之间的关系在各种研究中仍然不一致。目的：本系统综述和荟萃分析旨在评估不同人群中TyG指数与发生CKD风险之间的关系。方法：到2024年12月，在PubMed、ISI Web of Science和Scopus数据库中进行全面的文献检索。纳入了检查TyG指数与CKD风险之间关系的合格研究。采用随机效应模型计算合并效应大小（ES）。根据研究设计、人群特征和方法学质量进行亚组分析。结果：共纳入33项观察性研究，包括322,394名参与者。荟萃分析显示，较高的TyG指数与CKD风险增加之间存在显著关联(汇总ES: 1.67；95% CI: 1.51-1.86, P < 0.001)作为分类变量进行分析。当将TyG指数作为一个连续变量评估时，也观察到类似的显著关联(合并ES: 1.44；95% ci: 1.28-1.62, p < 0.001)。亚组分析表明，这种关联在不同的研究设计、地理区域和人群特征中是一致的。结论：研究结果表明，TyG指数是CKD风险的可靠预测指标，可作为早期识别高风险个体的有价值工具。未来的研究应侧重于探索潜在的机制，并评估TyG指数在CKD筛查和预防策略中的临床应用。
Investigating the association between Triglyceride-glucose index and risk of chronic kidney disease: A systematic review and meta-analysis.
Background: Chronic kidney disease (CKD) has emerged as a critical public health issue, with its global prevalence steadily rising. Insulin resistance has been recognized as a significant contributor to the progression of CKD. The triglyceride-glucose (TyG) index, an established surrogate marker of insulin resistance, has been suggested as a potential predictor for CKD risk. However, the relationship between the TyG index and CKD remains inconsistent across various studies.
Objective: This systematic review and meta-analysis aimed to evaluate the association between the TyG index and risk of developing CKD across diverse populations.
Methods: A comprehensive literature search was conducted in the PubMed, ISI Web of Science, and Scopus databases through December 2024. Eligible studies examining the association between the TyG index and CKD risk were included. The pooled effect size (ES) was calculated using a random-effects model. Subgroup analyses were conducted based on study design, population characteristics, and methodological quality.
Results: A total of 33 observational studies, encompassing 322,394 participants, were included. The meta-analysis revealed a significant association between a higher TyG index and an increased risk of CKD (pooled ES: 1.67; 95% CI: 1.51-1.86, P < 0.001) when analyzed as a categorical variable. A similar significant association was observed when the TyG index was assessed as a continuous variable (pooled ES: 1.44; 95% CI: 1.28-1.62, P < 0.001). Subgroup analyses indicated that this association was consistent across various study designs, geographic regions, and population characteristics.
Conclusion: The findings suggest that the TyG index is a reliable predictor of CKD risk and may serve as a valuable tool for the early identification of individuals at high risk. Future research should focus on exploring the underlying mechanisms and evaluating the clinical utility of the TyG index in CKD screening and prevention strategies.
期刊介绍：
Clinical Nutrition ESPEN is an electronic-only journal and is an official publication of the European Society for Clinical Nutrition and Metabolism (ESPEN). Nutrition and nutritional care have gained wide clinical and scientific interest during the past decades. The increasing knowledge of metabolic disturbances and nutritional assessment in chronic and acute diseases has stimulated rapid advances in design, development and clinical application of nutritional support. The aims of ESPEN are to encourage the rapid diffusion of knowledge and its application in the field of clinical nutrition and metabolism. Published bimonthly, Clinical Nutrition ESPEN focuses on publishing articles on the relationship between nutrition and disease in the setting of basic science and clinical practice. Clinical Nutrition ESPEN is available to all members of ESPEN and to all subscribers of Clinical Nutrition.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
