LncRNA-蛋白相互作用:破译LncRNA机制的关键。

IF 4.8 2区 生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
Biomolecules Pub Date : 2025-06-17 DOI:10.3390/biom15060881
Zuoneng Wang, Muhammad Aftab, Zigang Dong, Yanan Jiang, Kangdong Liu
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引用次数: 0

摘要

长链非编码rna (lncRNAs)已成为众多生物过程中的关键调控因子。然而,它们的功能基础,特别是基于结构的功能特征仍然是难以捉摸的。lncrna主要通过与各种细胞成分的复杂相互作用来发挥其影响。其中,与蛋白质的相互作用引起了越来越多的关注。最近的研究强调了与蛋白质相互作用作为lncRNA功能潜在机制的重要性。在这里,我们深入研究lncRNAs和rna结合蛋白(rbp)之间的相互作用,探索它们在细胞过程中的意义,并研究表征这些相互作用的生物信息学和实验方法。我们引入了一种创新的ISD策略来破译lncrna的神秘机制。通过回顾蛋白质及其复合物研究的最新进展,我们将ISD策略纳入我们的综合结构分析管道,以全面了解lncrna的结构-功能关系。本文对基于lncrna -蛋白相互作用(lpi)的创新治疗方法的发展进展进行了综述。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
LncRNA-Protein Interactions: A Key to Deciphering LncRNA Mechanisms.

Long non-coding RNAs (lncRNAs) have emerged as pivotal regulators in a multitude of biological processes. However, their functional basis, particularly structure-based functional characteristics, remains elusive. lncRNAs exert their influence primarily through intricate interactions with various cellular components. Among these, interactions with proteins have garnered increasing attention. Recent research highlights the significance of the interactions with proteins as a plausible mechanism underlying lncRNA functions. Here, we delve into the interactions between lncRNAs and RNA-binding proteins (RBPs), explore their implications in cellular processes, and examine bioinformatic and experimental approaches for characterizing these interactions. We introduce an innovative ISD strategy to decipher the mysterious mechanism of lncRNAs. Through reviewing the recent advances in the study of proteins and their complexes, we incorporate the ISD strategy into our integrated structural analysis pipeline for comprehensively understanding the structure-function relationship of lncRNAs. Advances in the development of innovative therapeutic approaches based on lncRNA-protein interactions (LPIs) are reviewed accordingly.

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来源期刊
Biomolecules
Biomolecules Biochemistry, Genetics and Molecular Biology-Molecular Biology
CiteScore
9.40
自引率
3.60%
发文量
1640
审稿时长
18.28 days
期刊介绍: Biomolecules (ISSN 2218-273X) is an international, peer-reviewed open access journal focusing on biogenic substances and their biological functions, structures, interactions with other molecules, and their microenvironment as well as biological systems. Biomolecules publishes reviews, regular research papers and short communications.  Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced.
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