Auto-Segmentation and Auto-Planning in Automated Radiotherapy for Prostate Cancer.

Objective: The objective of this study was to develop and assess the clinical feasibility of auto-segmentation and auto-planning methodologies for automated radiotherapy in prostate cancer. Methods: A total of 166 patients were used to train a 3D Unet model for segmentation of the gross tumor volume (GTV), clinical tumor volume (CTV), nodal CTV (CTVnd), and organs at risk (OARs). Performance was assessed by the Dice similarity coefficient (DSC), the Recall, Precision, Volume Ratio (VR), the 95% Hausdorff distance (HD95%), and the volumetric revision degree (VRD). An auto-planning network based on a 3D Unet was trained on 77 treatment plans derived from the 166 patients. Dosimetric differences and clinical acceptability of the auto-plans were studied. The effect of OAR editing on dosimetry was also evaluated. Results: On an independent set of 50 cases, the auto-segmentation process took 1 min 20 s per case. The DSCs for GTV, CTV, and CTVnd were 0.87, 0.88, and 0.82, respectively, with VRDs ranging from 0.09 to 0.14. The segmentation of OARs demonstrated high accuracy (DSC ≥ 0.83, Recall/Precision ≈ 1.0). The auto-planning process required 1-3 optimization iterations for 50%, 40%, and 10% of cases, respectively, and exhibited significant better conformity (p ≤ 0.01) and OAR sparing (p ≤ 0.03) while maintaining comparable target coverage. Only 6.7% of auto-plans were deemed unacceptable compared to 20% of manual plans, with 75% of auto-plans considered superior. Notably, the editing of OARs had no significant impact on doses. Conclusions: The accuracy of auto-segmentation is comparable to that of manual segmentation, and the auto-planning offers equivalent or better OAR protection, meeting the requirements of online automated radiotherapy and facilitating its clinical application.