Adam Whitelock, Katherine Nash, Keely Sayer, Wendy Goodwin
{"title":"猫尾腔静脉与主动脉的比值和左心房与主动脉根的比值在急性高血容量时增加。","authors":"Adam Whitelock, Katherine Nash, Keely Sayer, Wendy Goodwin","doi":"10.2460/ajvr.25.04.0114","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the caudal vena cava-to-aorta (CVC:Ao) ratio at the hepatorenal location and left atrial-to-aortic root (LA:Ao) ratio as ultrasonographic indicators of acute hypervolemia in cats.</p><p><strong>Methods: </strong>10 healthy adult cats underwent general anesthesia with sevoflurane and were experimentally administered incremental volumes of lactated Ringer solution to achieve cumulative blood volume increases of 50%, 100%, 150%, and 200%. Point-of-care ultrasound measurements of the CVC:Ao and LA:Ao ratios were obtained at baseline, following each fluid bolus, and 15 minutes after the final infusion. All measurements were performed in triplicate.</p><p><strong>Results: </strong>Both CVC:Ao and LA:Ao ratios demonstrated increases from baseline at all time points. Following the initial fluid bolus (50% blood volume), the mean CVC:Ao ratio increased by 47% (mean difference, -0.51; 95% CI, -0.74 to 0.28), and the LA:Ao ratio increased by 26% (mean difference, -0.33; 95% CI, -0.58 to 0.07) from baseline. During the redistribution phase (15 minutes following final infusion), the LA:Ao ratio decreased significantly compared to postinfusion values, while the CVC:Ao ratio did not. Intraobserver reliability was good to excellent for the LA:Ao ratio (intraclass correlation coefficient, 0.88; 95% CI, 0.82 to 0.92) and moderate to good for the CVC:Ao ratio (intraclass correlation coefficient, 0.79; 95% CI, 0.70 to 0.86).</p><p><strong>Conclusions: </strong>The CVC:Ao and LA:Ao ratios increased during acute hypervolemia in cats. The ultrasonographic measurements demonstrated good to excellent intraobserver reliability. The decrease in the LA:Ao ratio during the redistribution phase supports previous findings regarding rapid crystalloid redistribution in cats.</p><p><strong>Clinical relevance: </strong>The CVC:Ao and LA:Ao ratios may serve as useful indicators of volume status in feline patients; however, studies in conscious clinical patients are warranted to further validate these findings in cats.</p>","PeriodicalId":7754,"journal":{"name":"American journal of veterinary research","volume":" ","pages":"1-6"},"PeriodicalIF":1.3000,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Feline caudal vena cava-to-aorta ratio and left atrial-to-aortic root ratio increase in acute hypervolemia.\",\"authors\":\"Adam Whitelock, Katherine Nash, Keely Sayer, Wendy Goodwin\",\"doi\":\"10.2460/ajvr.25.04.0114\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>To evaluate the caudal vena cava-to-aorta (CVC:Ao) ratio at the hepatorenal location and left atrial-to-aortic root (LA:Ao) ratio as ultrasonographic indicators of acute hypervolemia in cats.</p><p><strong>Methods: </strong>10 healthy adult cats underwent general anesthesia with sevoflurane and were experimentally administered incremental volumes of lactated Ringer solution to achieve cumulative blood volume increases of 50%, 100%, 150%, and 200%. Point-of-care ultrasound measurements of the CVC:Ao and LA:Ao ratios were obtained at baseline, following each fluid bolus, and 15 minutes after the final infusion. All measurements were performed in triplicate.</p><p><strong>Results: </strong>Both CVC:Ao and LA:Ao ratios demonstrated increases from baseline at all time points. Following the initial fluid bolus (50% blood volume), the mean CVC:Ao ratio increased by 47% (mean difference, -0.51; 95% CI, -0.74 to 0.28), and the LA:Ao ratio increased by 26% (mean difference, -0.33; 95% CI, -0.58 to 0.07) from baseline. During the redistribution phase (15 minutes following final infusion), the LA:Ao ratio decreased significantly compared to postinfusion values, while the CVC:Ao ratio did not. Intraobserver reliability was good to excellent for the LA:Ao ratio (intraclass correlation coefficient, 0.88; 95% CI, 0.82 to 0.92) and moderate to good for the CVC:Ao ratio (intraclass correlation coefficient, 0.79; 95% CI, 0.70 to 0.86).</p><p><strong>Conclusions: </strong>The CVC:Ao and LA:Ao ratios increased during acute hypervolemia in cats. The ultrasonographic measurements demonstrated good to excellent intraobserver reliability. The decrease in the LA:Ao ratio during the redistribution phase supports previous findings regarding rapid crystalloid redistribution in cats.</p><p><strong>Clinical relevance: </strong>The CVC:Ao and LA:Ao ratios may serve as useful indicators of volume status in feline patients; however, studies in conscious clinical patients are warranted to further validate these findings in cats.</p>\",\"PeriodicalId\":7754,\"journal\":{\"name\":\"American journal of veterinary research\",\"volume\":\" \",\"pages\":\"1-6\"},\"PeriodicalIF\":1.3000,\"publicationDate\":\"2025-06-25\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"American journal of veterinary research\",\"FirstCategoryId\":\"97\",\"ListUrlMain\":\"https://doi.org/10.2460/ajvr.25.04.0114\",\"RegionNum\":3,\"RegionCategory\":\"农林科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"VETERINARY SCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"American journal of veterinary research","FirstCategoryId":"97","ListUrlMain":"https://doi.org/10.2460/ajvr.25.04.0114","RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"VETERINARY SCIENCES","Score":null,"Total":0}
Feline caudal vena cava-to-aorta ratio and left atrial-to-aortic root ratio increase in acute hypervolemia.
Objective: To evaluate the caudal vena cava-to-aorta (CVC:Ao) ratio at the hepatorenal location and left atrial-to-aortic root (LA:Ao) ratio as ultrasonographic indicators of acute hypervolemia in cats.
Methods: 10 healthy adult cats underwent general anesthesia with sevoflurane and were experimentally administered incremental volumes of lactated Ringer solution to achieve cumulative blood volume increases of 50%, 100%, 150%, and 200%. Point-of-care ultrasound measurements of the CVC:Ao and LA:Ao ratios were obtained at baseline, following each fluid bolus, and 15 minutes after the final infusion. All measurements were performed in triplicate.
Results: Both CVC:Ao and LA:Ao ratios demonstrated increases from baseline at all time points. Following the initial fluid bolus (50% blood volume), the mean CVC:Ao ratio increased by 47% (mean difference, -0.51; 95% CI, -0.74 to 0.28), and the LA:Ao ratio increased by 26% (mean difference, -0.33; 95% CI, -0.58 to 0.07) from baseline. During the redistribution phase (15 minutes following final infusion), the LA:Ao ratio decreased significantly compared to postinfusion values, while the CVC:Ao ratio did not. Intraobserver reliability was good to excellent for the LA:Ao ratio (intraclass correlation coefficient, 0.88; 95% CI, 0.82 to 0.92) and moderate to good for the CVC:Ao ratio (intraclass correlation coefficient, 0.79; 95% CI, 0.70 to 0.86).
Conclusions: The CVC:Ao and LA:Ao ratios increased during acute hypervolemia in cats. The ultrasonographic measurements demonstrated good to excellent intraobserver reliability. The decrease in the LA:Ao ratio during the redistribution phase supports previous findings regarding rapid crystalloid redistribution in cats.
Clinical relevance: The CVC:Ao and LA:Ao ratios may serve as useful indicators of volume status in feline patients; however, studies in conscious clinical patients are warranted to further validate these findings in cats.
期刊介绍：
The American Journal of Veterinary Research supports the collaborative exchange of information between researchers and clinicians by publishing novel research findings that bridge the gulf between basic research and clinical practice or that help to translate laboratory research and preclinical studies to the development of clinical trials and clinical practice. The journal welcomes submission of high-quality original studies and review articles in a wide range of scientific fields, including anatomy, anesthesiology, animal welfare, behavior, epidemiology, genetics, heredity, infectious disease, molecular biology, oncology, pharmacology, pathogenic mechanisms, physiology, surgery, theriogenology, toxicology, and vaccinology. Species of interest include production animals, companion animals, equids, exotic animals, birds, reptiles, and wild and marine animals. Reports of laboratory animal studies and studies involving the use of animals as experimental models of human diseases are considered only when the study results are of demonstrable benefit to the species used in the research or to another species of veterinary interest. Other fields of interest or animals species are not necessarily excluded from consideration, but such reports must focus on novel research findings. Submitted papers must make an original and substantial contribution to the veterinary medicine knowledge base; preliminary studies are not appropriate.
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