抗病毒药物的再利用:不同的方法和抗真菌药物的案例。

IF 12 1区 医学 Q1 PHARMACOLOGY & PHARMACY
Sara Tuci , Beatrice Mercorelli , Arianna Loregian
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引用次数: 0

摘要

近年来,新病毒的出现和旧病毒的重现给全球公共卫生带来了重大挑战。发病率和死亡率高的病毒有可能迅速传播,造成大规模流行病爆发,甚至大流行。在这种情况下,病毒感染仍然缺乏有效治疗,对人类健康构成严重威胁。因此,迫切需要持续制定和实施针对这些感染的对策,因为它们是针对正在迅速出现耐药性的疾病的对策。在这方面,与从头开始的药物发现相比,药物再利用可能是一种高效、更快、更经济的新药开发策略。在这里,我们全面回顾了用于药物再利用的不同实验和计算方法,并讨论了它们与其他药物发现策略相比的优点和局限性。此外,作为药物再利用成功应用的一个例子,我们提出了批准的抗真菌药物可以再利用来抵抗病毒感染的案例。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Antiviral drug repurposing: different approaches and the case of antifungal drugs
In recent years, the emergence of new viruses and the re-emergence of old ones have posed a significant challenge to global Public Health. Viruses characterised by high morbidity and mortality rates have the potential to spread rapidly, causing large epidemic outbreaks and even pandemics. In this context, viral infections still lacking effective treatments represent a serious threat to human health. For this reason, sustained development and implementation of countermeasures are urgently needed against these infections, as they are for diseases for which the emergence of drug resistance is rapidly increasing. In this regard, compared to de novo drug discovery, drug repurposing could represent a highly efficient, faster, and more affordable strategy to develop new drugs. Here, we provide a comprehensive review of the different experimental and computational approaches used for drug repurposing and discuss their advantages and limitations in comparison with other drug discovery strategies. In addition, as an example of the successful application of drug repurposing, we present the case of approved antifungal drugs that could be repurposed to counteract viral infections.
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来源期刊
CiteScore
23.00
自引率
0.70%
发文量
222
审稿时长
90 days
期刊介绍: Pharmacology & Therapeutics, in its 20th year, delivers lucid, critical, and authoritative reviews on current pharmacological topics.Articles, commissioned by the editor, follow specific author instructions.This journal maintains its scientific excellence and ranks among the top 10 most cited journals in pharmacology.
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