内部水诱导的加速,化学途径,以及降解聚乳酸-羟基乙酸(PLGA)微粒和器件的影响因素。

IF 5.4 2区 医学 Q2 MATERIALS SCIENCE, BIOMATERIALS
Joseph B Mayer, Samruddhi M Patil, Sung-Ho Shin, Jin Yoo, You-Yeon Won
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引用次数: 0

摘要

聚乳酸(PLA)和聚乳酸-羟基乙酸(PLGA)是经fda批准的可生物降解聚合物,广泛应用于医疗领域,特别是在药物控制释放系统和手术器械中。为了能够预测和控制这类系统的降解动力学,有必要研究各种参数对降解速率的影响。本文对聚乳酸和聚乳酸的水解降解进行了综述。综述了溶剂介电常数、pH、乳酸盐和乙醇酸盐含量、立体异构体和结晶度、降解温度、玻璃化转变温度(Tg)和熔融温度(Tm)、PLGA共聚物中单体序列和聚合物分子量对PLA/PLGA的影响。解决了体外/体内相关性(IVIVC)的局限性。本文的主要目的是全面回顾文献中关于PLA/PLGA水解降解的结果,并澄清某些方面仍然不太清楚。特别是,我们的目标是提供见解的因素,在相对较新的研究报告的不同的,有时是对比的发现。我们对PLA/PLGA矩阵核心的加速降解提出了一种新的解释──内部水诱导加速──并讨论了这一观点如何为现有的酸加速模型提供了一种替代方案,这些模型似乎不足以解释一些最近的数据。此外,我们还讨论了与以下相关的主题:(i)散装基质中不存在反向反应,(ii)水和降解产物的质量传输的存在和影响,以及(iii)单体序列对PLGA共聚物降解的影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Internal Water-Induced Acceleration, Chemical Pathways, and Contributing Factors in the Degradation of Poly(lactic-co-glycolic acid) (PLGA) Microparticles and Devices.

Poly(lactic acid) (PLA) and poly(lactic-co-glycolic acid) (PLGA) are FDA-approved, biodegradable polymers widely used in medical applications, especially in controlled drug release systems and surgical devices. To be able to predict and control the degradation kinetics of such systems, it is essential to study the effect of various parameters on the degradation rate. In this work, a review is presented concerning the hydrolytic degradation of PLA and PLGA. The effects of solvent dielectric constant, pH, lactate and glycolate content, stereoisomers and crystallinity, degradation temperature, glass transition temperature (Tg), and melting temperature (Tm), monomer sequence in PLGA copolymers, and polymer molecular weight in PLA/PLGA are reviewed. In vitro/in vivo correlation (IVIVC) limitations are addressed. The main purpose of this paper is to provide a comprehensive review of the results on the hydrolytic degradation of PLA/PLGA available in the literature and to offer clarification on certain aspects that remain less well understood. In particular, we aim to provide insights into the factors underlying the varying and sometimes contrasting findings reported in relatively recent studies. We propose a new explanation for accelerated degradation in the core of PLA/PLGA matrices─internal water-induced acceleration─and discuss how this perspective offers an alternative to existing acid-acceleration models, which appear insufficient to explain some of the more recent data. Additionally, we address topics related to (i) the absence of the backbiting reaction in bulk matrices, (ii) the presence and influence of mass transport of both water and the degradation products, and (iii) the effect of monomer sequence on PLGA copolymer degradation.

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来源期刊
ACS Biomaterials Science & Engineering
ACS Biomaterials Science & Engineering Materials Science-Biomaterials
CiteScore
10.30
自引率
3.40%
发文量
413
期刊介绍: ACS Biomaterials Science & Engineering is the leading journal in the field of biomaterials, serving as an international forum for publishing cutting-edge research and innovative ideas on a broad range of topics: Applications and Health – implantable tissues and devices, prosthesis, health risks, toxicology Bio-interactions and Bio-compatibility – material-biology interactions, chemical/morphological/structural communication, mechanobiology, signaling and biological responses, immuno-engineering, calcification, coatings, corrosion and degradation of biomaterials and devices, biophysical regulation of cell functions Characterization, Synthesis, and Modification – new biomaterials, bioinspired and biomimetic approaches to biomaterials, exploiting structural hierarchy and architectural control, combinatorial strategies for biomaterials discovery, genetic biomaterials design, synthetic biology, new composite systems, bionics, polymer synthesis Controlled Release and Delivery Systems – biomaterial-based drug and gene delivery, bio-responsive delivery of regulatory molecules, pharmaceutical engineering Healthcare Advances – clinical translation, regulatory issues, patient safety, emerging trends Imaging and Diagnostics – imaging agents and probes, theranostics, biosensors, monitoring Manufacturing and Technology – 3D printing, inks, organ-on-a-chip, bioreactor/perfusion systems, microdevices, BioMEMS, optics and electronics interfaces with biomaterials, systems integration Modeling and Informatics Tools – scaling methods to guide biomaterial design, predictive algorithms for structure-function, biomechanics, integrating bioinformatics with biomaterials discovery, metabolomics in the context of biomaterials Tissue Engineering and Regenerative Medicine – basic and applied studies, cell therapies, scaffolds, vascularization, bioartificial organs, transplantation and functionality, cellular agriculture
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