Joseph B Mayer, Samruddhi M Patil, Sung-Ho Shin, Jin Yoo, You-Yeon Won
{"title":"内部水诱导的加速,化学途径,以及降解聚乳酸-羟基乙酸(PLGA)微粒和器件的影响因素。","authors":"Joseph B Mayer, Samruddhi M Patil, Sung-Ho Shin, Jin Yoo, You-Yeon Won","doi":"10.1021/acsbiomaterials.5c00419","DOIUrl":null,"url":null,"abstract":"<p><p>Poly(lactic acid) (PLA) and poly(lactic-<i>co</i>-glycolic acid) (PLGA) are FDA-approved, biodegradable polymers widely used in medical applications, especially in controlled drug release systems and surgical devices. To be able to predict and control the degradation kinetics of such systems, it is essential to study the effect of various parameters on the degradation rate. In this work, a review is presented concerning the hydrolytic degradation of PLA and PLGA. The effects of solvent dielectric constant, pH, lactate and glycolate content, stereoisomers and crystallinity, degradation temperature, glass transition temperature (<i>T</i><sub>g</sub>), and melting temperature (<i>T</i><sub>m</sub>), monomer sequence in PLGA copolymers, and polymer molecular weight in PLA/PLGA are reviewed. In vitro/in vivo correlation (IVIVC) limitations are addressed. The main purpose of this paper is to provide a comprehensive review of the results on the hydrolytic degradation of PLA/PLGA available in the literature and to offer clarification on certain aspects that remain less well understood. In particular, we aim to provide insights into the factors underlying the varying and sometimes contrasting findings reported in relatively recent studies. We propose a new explanation for accelerated degradation in the core of PLA/PLGA matrices─internal water-induced acceleration─and discuss how this perspective offers an alternative to existing acid-acceleration models, which appear insufficient to explain some of the more recent data. Additionally, we address topics related to (i) the absence of the backbiting reaction in bulk matrices, (ii) the presence and influence of mass transport of both water and the degradation products, and (iii) the effect of monomer sequence on PLGA copolymer degradation.</p>","PeriodicalId":8,"journal":{"name":"ACS Biomaterials Science & Engineering","volume":" ","pages":""},"PeriodicalIF":5.4000,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Internal Water-Induced Acceleration, Chemical Pathways, and Contributing Factors in the Degradation of Poly(lactic-<i>co</i>-glycolic acid) (PLGA) Microparticles and Devices.\",\"authors\":\"Joseph B Mayer, Samruddhi M Patil, Sung-Ho Shin, Jin Yoo, You-Yeon Won\",\"doi\":\"10.1021/acsbiomaterials.5c00419\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Poly(lactic acid) (PLA) and poly(lactic-<i>co</i>-glycolic acid) (PLGA) are FDA-approved, biodegradable polymers widely used in medical applications, especially in controlled drug release systems and surgical devices. To be able to predict and control the degradation kinetics of such systems, it is essential to study the effect of various parameters on the degradation rate. In this work, a review is presented concerning the hydrolytic degradation of PLA and PLGA. The effects of solvent dielectric constant, pH, lactate and glycolate content, stereoisomers and crystallinity, degradation temperature, glass transition temperature (<i>T</i><sub>g</sub>), and melting temperature (<i>T</i><sub>m</sub>), monomer sequence in PLGA copolymers, and polymer molecular weight in PLA/PLGA are reviewed. In vitro/in vivo correlation (IVIVC) limitations are addressed. The main purpose of this paper is to provide a comprehensive review of the results on the hydrolytic degradation of PLA/PLGA available in the literature and to offer clarification on certain aspects that remain less well understood. In particular, we aim to provide insights into the factors underlying the varying and sometimes contrasting findings reported in relatively recent studies. We propose a new explanation for accelerated degradation in the core of PLA/PLGA matrices─internal water-induced acceleration─and discuss how this perspective offers an alternative to existing acid-acceleration models, which appear insufficient to explain some of the more recent data. Additionally, we address topics related to (i) the absence of the backbiting reaction in bulk matrices, (ii) the presence and influence of mass transport of both water and the degradation products, and (iii) the effect of monomer sequence on PLGA copolymer degradation.</p>\",\"PeriodicalId\":8,\"journal\":{\"name\":\"ACS Biomaterials Science & Engineering\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":5.4000,\"publicationDate\":\"2025-06-25\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"ACS Biomaterials Science & Engineering\",\"FirstCategoryId\":\"5\",\"ListUrlMain\":\"https://doi.org/10.1021/acsbiomaterials.5c00419\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"MATERIALS SCIENCE, BIOMATERIALS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"ACS Biomaterials Science & Engineering","FirstCategoryId":"5","ListUrlMain":"https://doi.org/10.1021/acsbiomaterials.5c00419","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"MATERIALS SCIENCE, BIOMATERIALS","Score":null,"Total":0}
Internal Water-Induced Acceleration, Chemical Pathways, and Contributing Factors in the Degradation of Poly(lactic-co-glycolic acid) (PLGA) Microparticles and Devices.
Poly(lactic acid) (PLA) and poly(lactic-co-glycolic acid) (PLGA) are FDA-approved, biodegradable polymers widely used in medical applications, especially in controlled drug release systems and surgical devices. To be able to predict and control the degradation kinetics of such systems, it is essential to study the effect of various parameters on the degradation rate. In this work, a review is presented concerning the hydrolytic degradation of PLA and PLGA. The effects of solvent dielectric constant, pH, lactate and glycolate content, stereoisomers and crystallinity, degradation temperature, glass transition temperature (Tg), and melting temperature (Tm), monomer sequence in PLGA copolymers, and polymer molecular weight in PLA/PLGA are reviewed. In vitro/in vivo correlation (IVIVC) limitations are addressed. The main purpose of this paper is to provide a comprehensive review of the results on the hydrolytic degradation of PLA/PLGA available in the literature and to offer clarification on certain aspects that remain less well understood. In particular, we aim to provide insights into the factors underlying the varying and sometimes contrasting findings reported in relatively recent studies. We propose a new explanation for accelerated degradation in the core of PLA/PLGA matrices─internal water-induced acceleration─and discuss how this perspective offers an alternative to existing acid-acceleration models, which appear insufficient to explain some of the more recent data. Additionally, we address topics related to (i) the absence of the backbiting reaction in bulk matrices, (ii) the presence and influence of mass transport of both water and the degradation products, and (iii) the effect of monomer sequence on PLGA copolymer degradation.
期刊介绍:
ACS Biomaterials Science & Engineering is the leading journal in the field of biomaterials, serving as an international forum for publishing cutting-edge research and innovative ideas on a broad range of topics:
Applications and Health – implantable tissues and devices, prosthesis, health risks, toxicology
Bio-interactions and Bio-compatibility – material-biology interactions, chemical/morphological/structural communication, mechanobiology, signaling and biological responses, immuno-engineering, calcification, coatings, corrosion and degradation of biomaterials and devices, biophysical regulation of cell functions
Characterization, Synthesis, and Modification – new biomaterials, bioinspired and biomimetic approaches to biomaterials, exploiting structural hierarchy and architectural control, combinatorial strategies for biomaterials discovery, genetic biomaterials design, synthetic biology, new composite systems, bionics, polymer synthesis
Controlled Release and Delivery Systems – biomaterial-based drug and gene delivery, bio-responsive delivery of regulatory molecules, pharmaceutical engineering
Healthcare Advances – clinical translation, regulatory issues, patient safety, emerging trends
Imaging and Diagnostics – imaging agents and probes, theranostics, biosensors, monitoring
Manufacturing and Technology – 3D printing, inks, organ-on-a-chip, bioreactor/perfusion systems, microdevices, BioMEMS, optics and electronics interfaces with biomaterials, systems integration
Modeling and Informatics Tools – scaling methods to guide biomaterial design, predictive algorithms for structure-function, biomechanics, integrating bioinformatics with biomaterials discovery, metabolomics in the context of biomaterials
Tissue Engineering and Regenerative Medicine – basic and applied studies, cell therapies, scaffolds, vascularization, bioartificial organs, transplantation and functionality, cellular agriculture