阿昔洛韦治疗贝尔氏麻痹的疗效

IF 1.8 4区医学 Q2 OTORHINOLARYNGOLOGY

American Journal of Otolaryngology Pub Date : 2025-04-28 DOI:10.1016/j.amjoto.2025.104637

Çağlar Günebakan , Selçuk Kuzu , Erhan Bozkurt

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引用次数: 0

摘要

目的分析强的松龙单用及阿昔洛韦联合强的松龙治疗贝尔麻痹的效果。方法在一所三级医院进行的前瞻性随机临床研究中，我们评估了63例贝尔麻痹患者。其中强的松龙单独治疗30例，强的松龙与阿昔洛韦联合治疗33例。我们使用House-Brackmann面神经分期量表评估面神经功能。我们在第1周、第3周、第6周和第12周完成了对患者的随访。结果根据House-Brackmann量表，阿昔洛韦+强的松龙组改善率为86.6%，强的松龙组改善率为90%（表2），两组结果无统计学差异(p >；0.05)。阿昔洛韦+强的松龙组的后遗症为23.3% (n = 7)，强的松龙组的后遗症为27.27% (n = 9)，但差异无统计学意义(p >；0.05)。结论阿昔洛韦联合类固醇治疗贝尔麻痹并不比单独使用类固醇有优势。

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Acyclovir efficacy for bell's palsy treatment

Purpose

This study aims to analyze the results regarding prednisolone alone, and the combined use of acyclovir with prednisolone in the treatment modality of Bell's palsy.

Methods

In this prospective, randomized clinical study, which was held in a single tertiary hospital, we evaluated 63 patients with Bell's palsy. 30 patients were given prednisolone alone, and we gave 33 patients prednisolone and acyclovir combination. We evaluated facial nerve functions using the House-Brackmann facial nerve staging scale. We completed the follow-up of the patients with the controls performed at 1st, 3rd, 6th, and 12th weeks.

Results

We determined improvement according to the House-Brackmann scale as 86.6 % in the acyclovir + prednisolone group and 90 % in the prednisolone group (Table 2), and there was no statistically significant difference between the results got from the treatment groups (p > 0.05). The sequelae were 23.3 % (n = 7) in the acyclovir + prednisolone group and 27.27 % (n = 9) in the prednisolone group, but this difference was not statistically significant (p > 0.05).

Conclusion

We observed that the combined use of acyclovir and steroids in Bell's palsy does not have the advantage over using steroids alone.

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来源期刊

American Journal of Otolaryngology 医学-耳鼻喉科学

CiteScore

4.40

自引率

4.00%

发文量

378

审稿时长

41 days

期刊介绍： Be fully informed about developments in otology, neurotology, audiology, rhinology, allergy, laryngology, speech science, bronchoesophagology, facial plastic surgery, and head and neck surgery. Featured sections include original contributions, grand rounds, current reviews, case reports and socioeconomics.