DMAPO/Boc2O介导的亚砜亚胺与羧酸的一锅直接N酰化反应

IF 2.5 3区化学 Q2 CHEMISTRY, ORGANIC

European Journal of Organic Chemistry Pub Date : 2025-06-26 DOI:10.1002/ejoc.202500488

Atsushi Umehara, Sukenao Kawai, Makoto Sasaki

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引用次数: 0

摘要

本报告描述了一种使用我们先前开发的4 - （N，N -二甲胺）吡啶N -氧化物(DMAPO)/二碳酸二叔丁基（Boc2O）体系直接将亚砜亚胺与羧酸进行一锅N -酰化的一般和简单的方法。该方法可以在温和的低温反应条件下进行，并且具有广泛的底物范围。该方法操作简单，可扩展，实用，因此在学术和工业实验室中都有广泛的应用。

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DMAPO/Boc2O‐Mediated One‐Pot Direct N‐Acylation of Sulfoximines with Carboxylic Acids

This report describes a general and simple method for the one‐pot direct N‐acylation of sulfoximines with carboxylic acids using our previously developed 4‐(N,N‐dimethylamino)pyridine N‐oxide (DMAPO)/di‐tert‐butyl dicarbonate (Boc2O) system. The method can be performed under mild low‐temperature reaction conditions and has a wide substrate scope. The present method is operationally simple, scalable, and practical, thus it should find wide applications in both academic and industrial laboratories.

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来源期刊

European Journal of Organic Chemistry 化学-有机化学

CiteScore

5.40

自引率

3.60%

发文量

752

审稿时长

1 months

期刊介绍： The European Journal of Organic Chemistry (2019 ISI Impact Factor 2.889) publishes Full Papers, Communications, and Minireviews from the entire spectrum of synthetic organic, bioorganic and physical-organic chemistry. It is published on behalf of Chemistry Europe, an association of 16 European chemical societies. The following journals have been merged to form two leading journals, the European Journal of Organic Chemistry and the European Journal of Inorganic Chemistry: Liebigs Annalen Bulletin des Sociétés Chimiques Belges Bulletin de la Société Chimique de France Gazzetta Chimica Italiana Recueil des Travaux Chimiques des Pays-Bas Anales de Química Chimika Chronika Revista Portuguesa de Química ACH—Models in Chemistry Polish Journal of Chemistry.