通过吲哚C-2烯化反应的环境敏感荧光色氨酸类似物

IF 4.2 2区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Chemical Communications Pub Date : 2025-06-26 DOI:10.1039/D5CC02114F

Valeria K. Burianova, Liyao Zeng, Abigail W. Thom, Niamh C. Radcliffe-Kennedy, Steven W. Magennis and Andrew Sutherland

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引用次数: 0

摘要

描述了一种模块化合成策略，通过C-2氧化和色氨酸衍生的四氢β-羰基化制备本质荧光的非天然α-氨基酸。这种方法产生了一种新的色氨酸-香豆素杂合体，具有很强的环境敏感性和与近红外双光子激发的兼容性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Environment-sensitive fluorescent tryptophan analogues via indole C-2 alkenylation reactions†

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Environment-sensitive fluorescent tryptophan analogues via indole C-2 alkenylation reactions†

A modular synthetic strategy for the preparation of intrinsically fluorescent unnatural α-amino acids by C-2 oxidation and alkenylation of a tryptophan-derived tetrahydro-β-carboline is described. This approach yielded a novel tryptophan–coumarin hybrid with strong environmental sensitivity and compatibility with near-infrared two-photon excitation.

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来源期刊

Chemical Communications 化学-化学综合

CiteScore

8.60

自引率

4.10%

发文量

2705

审稿时长

1.4 months

期刊介绍： ChemComm (Chemical Communications) is renowned as the fastest publisher of articles providing information on new avenues of research, drawn from all the world''s major areas of chemical research.