Guang-Shing Cheng,Ajay Sheshadri,Jane Turner,Kirsten M Williams,Joe L Hsu,Thomas Agoritsas,M Haider Ali,Louise Bondeelle,Guy Bouguet,Pascal Chanez,Kenneth R Cooke,Craig J Galban,Samuel Goldfarb,Teal S Hallstrand,Sarah Johnson,David C L Lam,David Michonneau,David N O'Dwyer,Sophie Paczesny,Husham Sharifi,Jamie L Todd,Daniel Wolff,Hemang Yadav,Gregory A Yanik,Anne Bergeron
{"title":"解决造血细胞移植后闭塞性细支气管炎综合征早期检测的知识空白。美国胸科学会官方研究报告。","authors":"Guang-Shing Cheng,Ajay Sheshadri,Jane Turner,Kirsten M Williams,Joe L Hsu,Thomas Agoritsas,M Haider Ali,Louise Bondeelle,Guy Bouguet,Pascal Chanez,Kenneth R Cooke,Craig J Galban,Samuel Goldfarb,Teal S Hallstrand,Sarah Johnson,David C L Lam,David Michonneau,David N O'Dwyer,Sophie Paczesny,Husham Sharifi,Jamie L Todd,Daniel Wolff,Hemang Yadav,Gregory A Yanik,Anne Bergeron","doi":"10.1164/rccm.202506-1352st","DOIUrl":null,"url":null,"abstract":"BACKGROUND\r\nBronchiolitis obliterans syndrome (BOS) is a late onset noninfectious pulmonary complication of allogeneic hematopoietic cell transplantation (HCT) that is often diagnosed in advanced stage with severe lung impairment. Increasing utilization of HCT for the treatment of hematologic diseases worldwide translates to an increasing burden of BOS, particularly for the community pulmonologist. Early recognition of BOS, which offers the best opportunity to mitigate morbidity and mortality, is hampered by incomplete knowledge of the clinical course and disease process. The goal of this research statement is to survey our current understanding of BOS and to define the research agenda for the early detection of BOS.\r\n\r\nMETHODS\r\nWe convened a multidisciplinary panel that included community representatives for an in-depth survey of the published literature followed by an online workshop.\r\n\r\nRESULTS\r\nMajor knowledge gaps were identified within interrelated themes of natural history and pathogenesis, risk factors, and the clinical diagnostic approach.\r\n\r\nCONCLUSIONS\r\nThis statement reflects the detailed assessment of identified knowledge gaps with associated key research questions, as well as a proposed research roadmap to stimulate cross-disciplinary collaborations from pre-clinical to clinical investigations.","PeriodicalId":7664,"journal":{"name":"American journal of respiratory and critical care medicine","volume":"243 1","pages":""},"PeriodicalIF":19.4000,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Addressing Knowledge Gaps in the Early Detection of Bronchiolitis Obliterans Syndrome After Hematopoietic Cell Transplantation. 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Addressing Knowledge Gaps in the Early Detection of Bronchiolitis Obliterans Syndrome After Hematopoietic Cell Transplantation. An Official American Thoracic Society Research Statement.
BACKGROUND
Bronchiolitis obliterans syndrome (BOS) is a late onset noninfectious pulmonary complication of allogeneic hematopoietic cell transplantation (HCT) that is often diagnosed in advanced stage with severe lung impairment. Increasing utilization of HCT for the treatment of hematologic diseases worldwide translates to an increasing burden of BOS, particularly for the community pulmonologist. Early recognition of BOS, which offers the best opportunity to mitigate morbidity and mortality, is hampered by incomplete knowledge of the clinical course and disease process. The goal of this research statement is to survey our current understanding of BOS and to define the research agenda for the early detection of BOS.
METHODS
We convened a multidisciplinary panel that included community representatives for an in-depth survey of the published literature followed by an online workshop.
RESULTS
Major knowledge gaps were identified within interrelated themes of natural history and pathogenesis, risk factors, and the clinical diagnostic approach.
CONCLUSIONS
This statement reflects the detailed assessment of identified knowledge gaps with associated key research questions, as well as a proposed research roadmap to stimulate cross-disciplinary collaborations from pre-clinical to clinical investigations.
期刊介绍:
The American Journal of Respiratory and Critical Care Medicine focuses on human biology and disease, as well as animal studies that contribute to the understanding of pathophysiology and treatment of diseases that affect the respiratory system and critically ill patients. Papers that are solely or predominantly based in cell and molecular biology are published in the companion journal, the American Journal of Respiratory Cell and Molecular Biology. The Journal also seeks to publish clinical trials and outstanding review articles on areas of interest in several forms. The State-of-the-Art review is a treatise usually covering a broad field that brings bench research to the bedside. Shorter reviews are published as Critical Care Perspectives or Pulmonary Perspectives. These are generally focused on a more limited area and advance a concerted opinion about care for a specific process. Concise Clinical Reviews provide an evidence-based synthesis of the literature pertaining to topics of fundamental importance to the practice of pulmonary, critical care, and sleep medicine. Images providing advances or unusual contributions to the field are published as Images in Pulmonary, Critical Care, Sleep Medicine and the Sciences.
A recent trend and future direction of the Journal has been to include debates of a topical nature on issues of importance in pulmonary and critical care medicine and to the membership of the American Thoracic Society. Other recent changes have included encompassing works from the field of critical care medicine and the extension of the editorial governing of journal policy to colleagues outside of the United States of America. The focus and direction of the Journal is to establish an international forum for state-of-the-art respiratory and critical care medicine.