金属基异质结在体外和体内控制多种阳离子和活性氧释放抑制多重耐药细菌。

IF 8.2 2区 材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY
Shaobo Guo, Murtala Bindawa Isah, Ruiling Hu, Zhongshang Guo, Xiaodan Wei, Zhifeng Liu, Xiaohui Ji*, Alberto C.P. Dias and Xiaoying Zhang*, 
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引用次数: 0

摘要

球形异质结纳米复合材料通过产生活性氧(ROS)和多个阳离子(多个带正电荷的无机或有机离子)来治疗耐药菌引起的伤口感染。然而,关于活性氧和多种阳离子对抗菌活性的相对贡献一直存在争议。本研究合成了CuFe2O4/Cu@PEI/Ag (ZPA)纳米复合材料,释放出丰富的•O2-、•OH、Fe3+、Cu2+、Ag+和聚乙烯亚胺(PEI),并研究了释放的离子对药物敏感金黄色葡萄球菌(ATCC25923)和耐药金黄色葡萄球菌(ATCC43360)抑菌活性的贡献。结果表明,其抑菌活性依次为:多阳离子>•O2->•OH >单阳离子。该材料的抗菌机制包括通过破坏细菌细胞壁使细胞质内容物渗漏,以及通过静电吸引将多个阳离子结合到细菌细胞壁上改变细胞壁的二级结构。ZPA通过愈合耐药金黄色葡萄球菌诱导的伤口感染,在11天后完全消除细菌负担,此外,ZPA还能在体内有效地将M1型巨噬细胞极化为M2型,促进伤口愈合。因此,我们的研究结果阐明了多阳离子在复合纳米材料的抗菌性能中占有重要地位。此外,ZPA代表了解决耐药金黄色葡萄球菌引起的伤口感染的有希望的策略。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

A Metal-Based Heterojunction for Controlled Release of Multiple Cations and Reactive Oxygen Species Inhibiting Multidrug-Resistant Bacteria In Vitro and In Vivo

A Metal-Based Heterojunction for Controlled Release of Multiple Cations and Reactive Oxygen Species Inhibiting Multidrug-Resistant Bacteria In Vitro and In Vivo

Spherical heterojunction nanocomposite materials are utilized to treat wound infections caused by drug-resistant bacteria by generating reactive oxygen species (ROS) and multiple cations (multiple inorganic or organic ions with positive points). However, there is an ongoing debate on the relative contributions of ROS and multiple cations toward antibacterial activity. In this study, the CuFe2O4/Cu@PEI/Ag (ZPA) nanocomposites were synthesized for releasing abundantO2–,OH, Fe3+, Cu2+, Ag+, and polyethylenimine (PEI), and studied the contribution of the released ions to the bacteriostatic activity against drug sensitive Staphylococcus aureus (ATCC25923) and drug-resistant S. aureus (ATCC43360). The results revealed that the antibacterial activity is attributed in the following order: multiple cations >O2–>OH > single cation. The antibacterial mechanism of the material involved leakage of the cytoplasmic content by damaging the bacterial cell wall, and the alteration of the secondary structure of the cell wall by multiple cations bound to the bacterial cell wall via electrostatic attraction. By healing drug-resistant S. aureus-induced wound infection and completely eliminating bacterial burden after 11 days, in addition, ZPA also effectively polarized M1 type macrophages to M2 type in vivo to promote wound healing. Thus, our findings elucidate that multiple cations occupy an important position on the antibacterial properties of composite nanomaterials. Moreover, The ZPA represent a promising strategy for addressing drug-resistant S. aureus-induced wound infections.

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来源期刊
ACS Applied Materials & Interfaces
ACS Applied Materials & Interfaces 工程技术-材料科学:综合
CiteScore
16.00
自引率
6.30%
发文量
4978
审稿时长
1.8 months
期刊介绍: ACS Applied Materials & Interfaces is a leading interdisciplinary journal that brings together chemists, engineers, physicists, and biologists to explore the development and utilization of newly-discovered materials and interfacial processes for specific applications. Our journal has experienced remarkable growth since its establishment in 2009, both in terms of the number of articles published and the impact of the research showcased. We are proud to foster a truly global community, with the majority of published articles originating from outside the United States, reflecting the rapid growth of applied research worldwide.
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