{"title":"人乳头瘤病毒疫苗接种在残疾和性取向交叉路口的差异。","authors":"Amarachukwu F Orji, Gilbert Gimm, Tarang Parekh, Rodman Turpin, Carolyn Drews-Botsch","doi":"10.1007/s10552-025-02025-z","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose: </strong>Although human papillomavirus (HPV) vaccination provides effective primary prevention against cervical cancer, HPV vaccination rates remain low in the U.S. It is unknown whether women with disabilities and/or LGB + women are likely to experience disparities in HPV vaccination uptake.</p><p><strong>Methods: </strong>We used data from the 2014-2022 Behavioral Risk Factor Surveillance System (N = 40,401) to estimate HPV vaccination rates among women aged 18-44 years. Adjusted prevalence ratios (aPRs) were estimated using modified Poisson regression models for four subgroups defined by disability status and LGB + status. Analyses were further stratified by age (18-26 years; 27-44 years).</p><p><strong>Results: </strong>Overall, only 19% of eligible women had received at least one dose of the HPV vaccine, and 12% had completed the full series. Younger women were more likely than older women to have been vaccinated. Compared with heterosexual women without disabilities, heterosexual women with disabilities, had lower vaccination uptake (heterosexual with disabilities: aPR = 0.95; 95% CI 0.93-0.97; LGB + with disabilities: aPR = 0.97; 95% CI 0.96-0.98), and were 12% less likely to complete the series (heterosexual with disabilities: aPR = 0.88; 95% CI 0.83-0.93).</p><p><strong>Conclusion: </strong>HPV vaccination rates remain low, representing missed opportunities for primary prevention. Women with disabilities had lower vaccination rates than women without disabilities and were less likely to complete the vaccine series. These findings, combined with age-stratified results, highlight the need for stronger catch-up campaigns and targeted efforts to address structural barriers related to disability, ultimately improving HPV vaccination coverage and reducing the burden of cervical cancer.</p>","PeriodicalId":520579,"journal":{"name":"Cancer causes & control : CCC","volume":" ","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Disparities in human papillomavirus vaccination uptake across the intersection of disability and sexual orientation.\",\"authors\":\"Amarachukwu F Orji, Gilbert Gimm, Tarang Parekh, Rodman Turpin, Carolyn Drews-Botsch\",\"doi\":\"10.1007/s10552-025-02025-z\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Purpose: </strong>Although human papillomavirus (HPV) vaccination provides effective primary prevention against cervical cancer, HPV vaccination rates remain low in the U.S. It is unknown whether women with disabilities and/or LGB + women are likely to experience disparities in HPV vaccination uptake.</p><p><strong>Methods: </strong>We used data from the 2014-2022 Behavioral Risk Factor Surveillance System (N = 40,401) to estimate HPV vaccination rates among women aged 18-44 years. Adjusted prevalence ratios (aPRs) were estimated using modified Poisson regression models for four subgroups defined by disability status and LGB + status. Analyses were further stratified by age (18-26 years; 27-44 years).</p><p><strong>Results: </strong>Overall, only 19% of eligible women had received at least one dose of the HPV vaccine, and 12% had completed the full series. Younger women were more likely than older women to have been vaccinated. Compared with heterosexual women without disabilities, heterosexual women with disabilities, had lower vaccination uptake (heterosexual with disabilities: aPR = 0.95; 95% CI 0.93-0.97; LGB + with disabilities: aPR = 0.97; 95% CI 0.96-0.98), and were 12% less likely to complete the series (heterosexual with disabilities: aPR = 0.88; 95% CI 0.83-0.93).</p><p><strong>Conclusion: </strong>HPV vaccination rates remain low, representing missed opportunities for primary prevention. Women with disabilities had lower vaccination rates than women without disabilities and were less likely to complete the vaccine series. These findings, combined with age-stratified results, highlight the need for stronger catch-up campaigns and targeted efforts to address structural barriers related to disability, ultimately improving HPV vaccination coverage and reducing the burden of cervical cancer.</p>\",\"PeriodicalId\":520579,\"journal\":{\"name\":\"Cancer causes & control : CCC\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2025-06-25\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Cancer causes & control : CCC\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1007/s10552-025-02025-z\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cancer causes & control : CCC","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1007/s10552-025-02025-z","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
摘要
目的:虽然人乳头瘤病毒(HPV)疫苗接种提供了有效的宫颈癌一级预防,但HPV疫苗接种率在美国仍然很低。尚不清楚残疾妇女和/或LGB +妇女在HPV疫苗接种率方面是否可能存在差异。方法:我们使用2014-2022年行为风险因素监测系统(N = 40401)的数据来估计18-44岁女性的HPV疫苗接种率。采用修正泊松回归模型对残疾状态和LGB +状态定义的四个亚组进行校正患病率(aPRs)估计。分析进一步按年龄分层(18-26岁;27-44年)。结果:总体而言,只有19%的符合条件的妇女接受了至少一剂HPV疫苗,12%的妇女完成了整个系列。年轻女性比年长女性更有可能接种疫苗。与没有残疾的异性恋女性相比,有残疾的异性恋女性疫苗接种率较低(有残疾的异性恋女性:aPR = 0.95;95% ci 0.93-0.97;LGB +残障:aPR = 0.97;95% CI 0.96-0.98),完成该系列研究的可能性降低12%(残疾异性恋者:aPR = 0.88;95% ci 0.83-0.93)。结论:HPV疫苗接种率仍然很低,错失了一级预防的机会。残疾妇女的疫苗接种率低于非残疾妇女,而且完成疫苗系列接种的可能性较小。这些发现,结合年龄分层的结果,强调需要加强追赶运动和有针对性的努力,以解决与残疾有关的结构性障碍,最终提高HPV疫苗接种覆盖率,减少宫颈癌的负担。
Disparities in human papillomavirus vaccination uptake across the intersection of disability and sexual orientation.
Purpose: Although human papillomavirus (HPV) vaccination provides effective primary prevention against cervical cancer, HPV vaccination rates remain low in the U.S. It is unknown whether women with disabilities and/or LGB + women are likely to experience disparities in HPV vaccination uptake.
Methods: We used data from the 2014-2022 Behavioral Risk Factor Surveillance System (N = 40,401) to estimate HPV vaccination rates among women aged 18-44 years. Adjusted prevalence ratios (aPRs) were estimated using modified Poisson regression models for four subgroups defined by disability status and LGB + status. Analyses were further stratified by age (18-26 years; 27-44 years).
Results: Overall, only 19% of eligible women had received at least one dose of the HPV vaccine, and 12% had completed the full series. Younger women were more likely than older women to have been vaccinated. Compared with heterosexual women without disabilities, heterosexual women with disabilities, had lower vaccination uptake (heterosexual with disabilities: aPR = 0.95; 95% CI 0.93-0.97; LGB + with disabilities: aPR = 0.97; 95% CI 0.96-0.98), and were 12% less likely to complete the series (heterosexual with disabilities: aPR = 0.88; 95% CI 0.83-0.93).
Conclusion: HPV vaccination rates remain low, representing missed opportunities for primary prevention. Women with disabilities had lower vaccination rates than women without disabilities and were less likely to complete the vaccine series. These findings, combined with age-stratified results, highlight the need for stronger catch-up campaigns and targeted efforts to address structural barriers related to disability, ultimately improving HPV vaccination coverage and reducing the burden of cervical cancer.