稀土掺杂上转换纳米生物检测材料研究进展。

IF 4.9 3区工程技术 Q1 CHEMISTRY, ANALYTICAL

Biosensors-Basel Pub Date : 2025-05-23 DOI:10.3390/bios15060335

Jiling Xu, Hengyuan Cao, Chenwei Wu, Ting Wang, Liheng Sun, Biao Dong

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引用次数: 0

摘要

稀土掺杂上转换纳米粒子（UCNPs）具有抗stokes位移、化学性质稳定、发射波长可调、生物毒性低等特点，在生物检测领域得到了广泛的应用。然而，它们的低荧光量子产率仍然是一个挑战。因此，构建基于UCNPs的高性能检测平台是一个关键的考虑因素。针对UCNPs在生物检测中的应用，介绍了上转换的基本原理和上转换荧光探针的设计。然后总结了增强上转换发光和三种生物传感平台格式的常见策略：基于解决方案的，基于条带的和基于板的。最后，对UCNPs在生物检测中的应用前景进行了展望。

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Recent Progress on Rare-Earth-Doped Upconversion Nanomaterials for Bioassay Applications.

Rare-earth-doped upconversion nanoparticles (UCNPs) have been widely used in biological detection due to their unique anti-Stokes shift, stable chemical properties, tunable emission wavelengths, and low biotoxicity. However, their low fluorescence quantum yield remains a challenge. Constructing a high-performance detection platform based on UCNPs is therefore a critical consideration. Focusing on the biological detection applications of UCNPs, this paper introduces the fundamental principles of upconversion and the design of upconversion fluorescence probes. It then summarizes common strategies for enhancing upconversion luminescence and three biosensing platform formats: solution-based, strip-based, and plate-based. Finally, future directions for UCNPs in biological detection are discussed.

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来源期刊

Biosensors-Basel Biochemistry, Genetics and Molecular Biology-Clinical Biochemistry

CiteScore

6.60

自引率

14.80%

发文量

983

审稿时长

11 weeks

期刊介绍： Biosensors (ISSN 2079-6374) provides an advanced forum for studies related to the science and technology of biosensors and biosensing. It publishes original research papers, comprehensive reviews and communications. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced. Electronic files and software regarding the full details of the calculation or experimental procedure, if unable to be published in a normal way, can be deposited as supplementary electronic material.