Fabiola Torres-Bernal, Julio Martínez-Burnes, Ismael Hernández-Avalos, Adriana Olmos-Hernández, Adriana Domínguez-OIiva, Brenda Reyes-Sotelo, Cynthia González-López, Diana Villanueva-Pereyra, Daniel Mota-Rojas
{"title":"利用大麻二酚、加巴喷丁和合成面部信息素三种药理模型,红外热像仪和生理变量识别家猫(Felis catus)恐惧。","authors":"Fabiola Torres-Bernal, Julio Martínez-Burnes, Ismael Hernández-Avalos, Adriana Olmos-Hernández, Adriana Domínguez-OIiva, Brenda Reyes-Sotelo, Cynthia González-López, Diana Villanueva-Pereyra, Daniel Mota-Rojas","doi":"10.3390/vetsci12060523","DOIUrl":null,"url":null,"abstract":"<p><p>This study aimed to assess changes in the surface temperature and physiological parameters of cats exposed to a fear model involving negative dog-cat interactions, receiving three pharmacological options: a single dose of cannabidiol, gabapentin, or synthetic facial pheromones. The surface temperature of the upper and lower limbs, facial, dorsal, and appendicular thermal windows was assessed through infrared thermography. Additionally, heart rate, respiratory rate, and rectal temperature were recorded. Eighty male and female domestic cats were included in the study and randomly divided into four groups: CONTROL (placebo, 2 mL/cat orally), CBD (cannabidiol, 2 mg/kg orally), GABA (gabapentin, 100 mg/cat orally), and SFP (synthetic facial pheromone, two sprays/carrier). All cats underwent six experimental phases: T<sub>basal-</sub>, T1st<sub>fear</sub>, T1st<sub>recovery</sub>, T<sub>basal+</sub>, T2nd<sub>fear</sub>, and T2nd<sub>recovery</sub>. Drug administration was carried out at the end of T1st<sub>recovery</sub>; the time between drug administration and T<sub>basal+</sub> differed according to each drug's nature. Statistical differences were obtained between experimental groups and times in the average surface temperature of thermal windows and cardiorespiratory parameters. In particular, the CBD, GABA, and SFP groups exhibited differences during T2nd<sub>fear</sub>, in contrast to the control and T1st<sub>fear</sub> groups. In conclusion, the results suggest a pharmacological effect of CBD, GABA, and SFP on cats' physiological alterations in response to fear.</p>","PeriodicalId":23694,"journal":{"name":"Veterinary Sciences","volume":"12 6","pages":""},"PeriodicalIF":2.0000,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12197366/pdf/","citationCount":"0","resultStr":"{\"title\":\"Infrared Thermography and Physiological Variables as Methods for Recognizing Fear in Domestic Cats (<i>Felis catus</i>) Using Three Pharmacological Models: Cannabidiol, Gabapentin, and Synthetic Facial Pheromones.\",\"authors\":\"Fabiola Torres-Bernal, Julio Martínez-Burnes, Ismael Hernández-Avalos, Adriana Olmos-Hernández, Adriana Domínguez-OIiva, Brenda Reyes-Sotelo, Cynthia González-López, Diana Villanueva-Pereyra, Daniel Mota-Rojas\",\"doi\":\"10.3390/vetsci12060523\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>This study aimed to assess changes in the surface temperature and physiological parameters of cats exposed to a fear model involving negative dog-cat interactions, receiving three pharmacological options: a single dose of cannabidiol, gabapentin, or synthetic facial pheromones. The surface temperature of the upper and lower limbs, facial, dorsal, and appendicular thermal windows was assessed through infrared thermography. Additionally, heart rate, respiratory rate, and rectal temperature were recorded. Eighty male and female domestic cats were included in the study and randomly divided into four groups: CONTROL (placebo, 2 mL/cat orally), CBD (cannabidiol, 2 mg/kg orally), GABA (gabapentin, 100 mg/cat orally), and SFP (synthetic facial pheromone, two sprays/carrier). All cats underwent six experimental phases: T<sub>basal-</sub>, T1st<sub>fear</sub>, T1st<sub>recovery</sub>, T<sub>basal+</sub>, T2nd<sub>fear</sub>, and T2nd<sub>recovery</sub>. Drug administration was carried out at the end of T1st<sub>recovery</sub>; the time between drug administration and T<sub>basal+</sub> differed according to each drug's nature. Statistical differences were obtained between experimental groups and times in the average surface temperature of thermal windows and cardiorespiratory parameters. In particular, the CBD, GABA, and SFP groups exhibited differences during T2nd<sub>fear</sub>, in contrast to the control and T1st<sub>fear</sub> groups. In conclusion, the results suggest a pharmacological effect of CBD, GABA, and SFP on cats' physiological alterations in response to fear.</p>\",\"PeriodicalId\":23694,\"journal\":{\"name\":\"Veterinary Sciences\",\"volume\":\"12 6\",\"pages\":\"\"},\"PeriodicalIF\":2.0000,\"publicationDate\":\"2025-05-27\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12197366/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Veterinary Sciences\",\"FirstCategoryId\":\"97\",\"ListUrlMain\":\"https://doi.org/10.3390/vetsci12060523\",\"RegionNum\":2,\"RegionCategory\":\"农林科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"VETERINARY SCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Veterinary Sciences","FirstCategoryId":"97","ListUrlMain":"https://doi.org/10.3390/vetsci12060523","RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"VETERINARY SCIENCES","Score":null,"Total":0}
Infrared Thermography and Physiological Variables as Methods for Recognizing Fear in Domestic Cats (Felis catus) Using Three Pharmacological Models: Cannabidiol, Gabapentin, and Synthetic Facial Pheromones.
This study aimed to assess changes in the surface temperature and physiological parameters of cats exposed to a fear model involving negative dog-cat interactions, receiving three pharmacological options: a single dose of cannabidiol, gabapentin, or synthetic facial pheromones. The surface temperature of the upper and lower limbs, facial, dorsal, and appendicular thermal windows was assessed through infrared thermography. Additionally, heart rate, respiratory rate, and rectal temperature were recorded. Eighty male and female domestic cats were included in the study and randomly divided into four groups: CONTROL (placebo, 2 mL/cat orally), CBD (cannabidiol, 2 mg/kg orally), GABA (gabapentin, 100 mg/cat orally), and SFP (synthetic facial pheromone, two sprays/carrier). All cats underwent six experimental phases: Tbasal-, T1stfear, T1strecovery, Tbasal+, T2ndfear, and T2ndrecovery. Drug administration was carried out at the end of T1strecovery; the time between drug administration and Tbasal+ differed according to each drug's nature. Statistical differences were obtained between experimental groups and times in the average surface temperature of thermal windows and cardiorespiratory parameters. In particular, the CBD, GABA, and SFP groups exhibited differences during T2ndfear, in contrast to the control and T1stfear groups. In conclusion, the results suggest a pharmacological effect of CBD, GABA, and SFP on cats' physiological alterations in response to fear.
期刊介绍:
Veterinary Sciences is an international and interdisciplinary scholarly open access journal. It publishes original that are relevant to any field of veterinary sciences, including prevention, diagnosis and treatment of disease, disorder and injury in animals. This journal covers almost all topics related to animal health and veterinary medicine. Research fields of interest include but are not limited to: anaesthesiology anatomy bacteriology biochemistry cardiology dentistry dermatology embryology endocrinology epidemiology genetics histology immunology microbiology molecular biology mycology neurobiology oncology ophthalmology parasitology pathology pharmacology physiology radiology surgery theriogenology toxicology virology.