SARS-CoV-2在哮喘儿童中的作用:不同内皮型的结果相同?

IF 3.4 3区 生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY
Metabolites Pub Date : 2025-06-16 DOI:10.3390/metabo15060406
Alice Bosco, Vassilios Fanos, Serena Bosone, Valeria Incandela, Federica La Ciacera, Angelica Dessì
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引用次数: 0

摘要

在严重急性呼吸综合征冠状病毒2 (SARS-CoV-2)大流行的早期阶段,人们对哮喘儿童的易感性感到担忧。哮喘是儿童最常见的慢性疾病之一,也是儿科机构住院治疗的主要原因。出乎意料的是,证据显示这些患者的临床病程较轻,哮喘发作较少,即使与患者特定临床特征相关的危重和致命感染病例也不容忽视。在这方面,肥胖不仅被认为是难治性哮喘患者的重要合并症,也是更严重形式的COVID-19的危险因素。在儿童肥胖增加的背景下,这些观察结果更令人担忧,儿童肥胖甚至在SARS-CoV-2大流行之前就开始增加,并因此而继续增加。鉴于哮喘的异质性,尤其是儿童哮喘,基于内型的治疗方法至关重要。这可以通过对哮喘、COVID-19感染和肥胖相关的复杂代谢途径的详细分析来实现,这要感谢新的高通量技术,特别是代谢组学,它通过包括呼气冷凝物(EBC)在内的微创采样,可以提供精确和公正的证据来支持现有的内型,不仅可以识别最脆弱的个体,从而通过特定的生物标志物进行风险分层,还有新的分子和治疗靶点。本综述通过强调哮喘内型与COVID-19共享的免疫代谢途径来探讨哮喘内型。研究结果表明,代谢组学可以在病毒大流行期间实现更准确的风险分层,并指导个性化干预,特别是在存在相关合并症(如肥胖)的情况下。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
SARS-CoV-2 in Asthmatic Children: Same Consequences in Different Endotypes?

During the early stages of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, concerns arose regarding the susceptibility of asthmatic children, one of the most common chronic conditions in childhood and a major cause of hospitalization in pediatric settings. Unexpectedly, evidences showed milder clinical courses and fewer asthma exacerbations in these patients, even if cases of critical and fatal infection, often related to specific clinical features of the patient, are not negligible. In this regard, obesity is considered not only an important comorbidity in patients with difficult-to-treat asthma but also a risk factor for more severe forms of COVID-19. These observations are of even greater concern in the context of an increase in childhood obesity that began even before the SARS-CoV-2 pandemic and has continued also as a consequence of it. Given asthma's heterogeneity, especially in children, an endotype-based approach is crucial. This is possible through a detailed analysis of the complex metabolic pathways that correlate asthma, COVID-19 infection and obesity thanks to new high-through-put technologies, especially metabolomics, which with minimally invasive sampling, including on exhaled breath condensate (EBC), can provide precise and unbiased evidence in support of existing endotypes, making it possible to identify not only the most vulnerable individuals and thus risk stratification through specific biomarkers, but also new molecular and therapeutic targets. This review explores asthma endotypes by highlighting their shared immunometabolic pathways with COVID-19. Findings suggest that metabolomics could enable more accurate risk stratification and guide personalized interventions during viral pandemics, especially in the presence of relevant comorbidities such as obesity.

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来源期刊
Metabolites
Metabolites Biochemistry, Genetics and Molecular Biology-Molecular Biology
CiteScore
5.70
自引率
7.30%
发文量
1070
审稿时长
17.17 days
期刊介绍: Metabolites (ISSN 2218-1989) is an international, peer-reviewed open access journal of metabolism and metabolomics. Metabolites publishes original research articles and review articles in all molecular aspects of metabolism relevant to the fields of metabolomics, metabolic biochemistry, computational and systems biology, biotechnology and medicine, with a particular focus on the biological roles of metabolites and small molecule biomarkers. Metabolites encourages scientists to publish their experimental and theoretical results in as much detail as possible. Therefore, there is no restriction on article length. Sufficient experimental details must be provided to enable the results to be accurately reproduced. Electronic material representing additional figures, materials and methods explanation, or supporting results and evidence can be submitted with the main manuscript as supplementary material.
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