失眠,认知障碍,或两者的结合,改变脂质代谢由于老年人酰基肉碱浓度的变化。

IF 3.4 3区 生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY
Metabolites Pub Date : 2025-06-19 DOI:10.3390/metabo15060417
Selma Karime Castillo-Vazquez, Berenice Palacios-González, Marcela Vela-Amieva, Isabel Ibarra-González, Ricardo Morales, Paola García-delaTorre, Sergio Sánchez-García, Carmen García-Peña, Ricardo Reyes-Chilpa, Raúl Hernán Medina-Campos, Jessica Hernández-Pineda, Juan Carlos Gomez-Verjan, Nadia Alejandra Rivero-Segura
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引用次数: 0

摘要

背景/目的:失眠与认知障碍(CI)有着广泛的联系。然而,这两个实体(失眠和CI)之间的关系却知之甚少。在这种情况下,失眠的成年人表现出代谢变化,包括支链氨基酸、甘油磷脂、谷胱甘肽和谷氨酸生物合成的分解代谢的改变。然而,衰老本身会引起代谢变化,这些变化可能会被慢性疾病放大,从而损害老年人的健康。因此,在本研究中,我们的目标是单独描述失眠和CI的代谢组学特征,以解决当前研究中关于失眠可能导致老年人CI的途径的重大空白。方法:在这项研究中,我们对来自墨西哥老年人肥胖、肌肉减少和虚弱队列(COSFOMA)的80个血清样本进行了靶向代谢组学分析(UPLC-MS);将这些样本分为四组(对照组、失眠组、CI组和失眠+ CI组)。结果:我们的研究结果表明,与CI组相比,失眠增加了酰基肉碱(C10, C8, C14, C12:1, C18:1和C18)的浓度,而老年CI组显示酰基肉碱C16, C10和C8的浓度降低。最后,有两种情况(失眠+ CI)的个体显示,与对照组相比,只有酰基肉碱C16的浓度下降。结论:综上所述,我们的研究结果揭示了失眠与老年人脂质代谢的相关性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Insomnia, Cognitive Impairment, or a Combination of Both, Alter Lipid Metabolism Due to Changes in Acylcarnitine Concentration in Older Persons.

Background/objectives: Insomnia has been widely associated with cognitive impairment (CI). However, the relationship between the two entities (insomnia and CI) is poorly understood. In this context, adults with insomnia show metabolic changes, including alterations in the catabolism of branched-chain amino acids, glycerophospholipids, and glutathione and glutamate biosynthesis. Nevertheless, aging itself induces metabolic changes that may be amplified by chronic diseases that compromise the health of the elderly. Therefore, in the present study we aim to characterise metabolomic profiles of insomnia and CI alone in order to address a significant gap in current research regarding the pathways through which insomnia may lead to CI in older persons.

Methods: In this study we perform a targeted metabolomics analysis (UPLC-MS) on 80 serum samples from the Cohort of Obesity, Sarcopenia, and Frailty of Older Mexican Adults (COSFOMA); these samples were classified into four groups (control, insomnia, CI, and insomnia + CI).

Results: Our results show that insomnia increases the concentration of acylcarnitines (C10, C8, C14, C12:1, C18:1 and C18) as compared to CI group, while older persons with CI show a decrease the concentration of the acylcarnitines C16, C10 and C8. Finally, individuals with both conditions (insomnia + CI) show that only the concentration of the acylcarnitine C16 decreases compared to controls.

Conclusions: Taken together, our results shed light on the relevance of insomnia on lipid metabolism in older persons.

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来源期刊
Metabolites
Metabolites Biochemistry, Genetics and Molecular Biology-Molecular Biology
CiteScore
5.70
自引率
7.30%
发文量
1070
审稿时长
17.17 days
期刊介绍: Metabolites (ISSN 2218-1989) is an international, peer-reviewed open access journal of metabolism and metabolomics. Metabolites publishes original research articles and review articles in all molecular aspects of metabolism relevant to the fields of metabolomics, metabolic biochemistry, computational and systems biology, biotechnology and medicine, with a particular focus on the biological roles of metabolites and small molecule biomarkers. Metabolites encourages scientists to publish their experimental and theoretical results in as much detail as possible. Therefore, there is no restriction on article length. Sufficient experimental details must be provided to enable the results to be accurately reproduced. Electronic material representing additional figures, materials and methods explanation, or supporting results and evidence can be submitted with the main manuscript as supplementary material.
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