连接民族植物学知识和植物衍生天然产物发现的多组学方法。

IF 3.4 3区 生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY
Metabolites Pub Date : 2025-05-29 DOI:10.3390/metabo15060362
Kekeletso H Chele, Lizelle A Piater, Justin J J van der Hooft, Fidele Tugizimana
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引用次数: 0

摘要

几个世纪以来,植物源性天然产物(NPs)一直是传统医学的基础,提供了必要的治疗化合物。民族植物学知识在历史上指导了NP的发现,导致了阿司匹林、吗啡和青蒿素等关键药物的鉴定。然而,传统的生物活性导向的NP分离方法是劳动密集型的,并且由于专注于单一化合物,可能导致生物活性特性的丧失。基因组学、转录组学、蛋白质组学、代谢组学和表型组学等组学科学的进步与计算工具相结合,通过实现高通量筛选和更精确的化合物鉴定,彻底改变了NP研究。这篇综述探讨了如何将传统医学知识与多组学策略相结合来促进NP的发现。我们重点介绍了新兴的生物信息学工具、质谱技术和代谢基因组学方法,它们加速了植物源代谢物的鉴定、注释和功能表征。此外,我们还讨论了组学数据整合中的挑战,并提出了利用民族植物学知识进行靶向NP发现和药物开发的策略。通过将传统智慧与现代科学进步相结合,这种综合方法为新的治疗发现和药用植物的可持续利用铺平了道路。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Bridging Ethnobotanical Knowledge and Multi-Omics Approaches for Plant-Derived Natural Product Discovery.

For centuries, plant-derived natural products (NPs) have been fundamental to traditional medicine, providing essential therapeutic compounds. Ethnobotanical knowledge has historically guided NP discovery, leading to the identification of key pharmaceuticals such as aspirin, morphine, and artemisinin. However, conventional bioactivity-guided fractionation methods for NP isolation are labour-intensive and can result in the loss of bioactive properties due to the focus on a single compound. Advances in omics sciences-genomics, transcriptomics, proteomics, metabolomics, and phenomics-coupled with computational tools have altogether revolutionised NP research by enabling high-throughput screening and more precise compound identification. This review explores how integrating traditional medicinal knowledge with multi-omics strategies enhances NP discovery. We highlight emerging bioinformatics tools, mass spectrometry techniques, and metabologenomics approaches that accelerate the identification, annotation, and functional characterisation of plant-derived metabolites. Additionally, we discuss challenges in omics data integration and propose strategies to harness ethnobotanical knowledge for targeted NP discovery and drug development. By combining traditional wisdom with modern scientific advancements, this integrated approach paves the way for novel therapeutic discoveries and the sustainable utilisation of medicinal plants.

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来源期刊
Metabolites
Metabolites Biochemistry, Genetics and Molecular Biology-Molecular Biology
CiteScore
5.70
自引率
7.30%
发文量
1070
审稿时长
17.17 days
期刊介绍: Metabolites (ISSN 2218-1989) is an international, peer-reviewed open access journal of metabolism and metabolomics. Metabolites publishes original research articles and review articles in all molecular aspects of metabolism relevant to the fields of metabolomics, metabolic biochemistry, computational and systems biology, biotechnology and medicine, with a particular focus on the biological roles of metabolites and small molecule biomarkers. Metabolites encourages scientists to publish their experimental and theoretical results in as much detail as possible. Therefore, there is no restriction on article length. Sufficient experimental details must be provided to enable the results to be accurately reproduced. Electronic material representing additional figures, materials and methods explanation, or supporting results and evidence can be submitted with the main manuscript as supplementary material.
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