生命的生物分子基础。

IF 3.4 3区 生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY
Metabolites Pub Date : 2025-06-16 DOI:10.3390/metabo15060404
Janusz Wiesław Błaszczyk
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引用次数: 0

摘要

生命被描述为新陈代谢、体内平衡、自我组织、生长、适应、信息代谢和繁殖的能力。所有这些都是通过一系列自组织和自我维持的过程来实现的,其中能量和信息代谢起着主导作用。人体的能量代谢以葡萄糖和脂质代谢为基础。所有依赖能量的生命过程都由磷酸盐和钙信号控制。为了维持能量代谢的最佳水平,细胞、组织和神经系统相互沟通,作为这种信号的结果,代谢产生了自我意识,这允许良心的社会互动,这是人类生命最重要的决定因素。因此,我们身体的大脑表征和环境的自我中心表征就建立起来了。生命优化的最后一个决定因素是有限的生命/死亡周期,这在细胞和社会层面上表现出相同的模式。这篇叙事性评论是我第一次尝试将我们对生命现象的认识系统化。由于这一挑战的极端重要性,在这篇文章中,我试图总结目前关于基本生命过程的知识,即能量和信息代谢,从而发起关于我们物种的生命和未来的更广泛的讨论。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Biomolecular Basis of Life.

Life is defined descriptively by the capacity for metabolism, homeostasis, self-organization, growth, adaptation, information metabolism, and reproduction. All these are achieved by a set of self-organizing and self-sustaining processes, among which energy and information metabolism play a dominant role. The energy metabolism of the human body is based on glucose and lipid metabolism. All energy-dependent life processes are controlled by phosphate and calcium signaling. To maintain the optimal levels of energy metabolism, cells, tissues, and the nervous system communicate mutually, and as a result of this signaling, metabolism emerges with self-awareness, which allows for conscience social interactions, which are the most significant determinants of human life. Consequently, the brain representation of our body and the egocentric representation of the environment are built. The last determinant of life optimization is the limited life/death cycle, which exhibits the same pattern at cellular and social levels. This narrative review is my first attempt to systematize our knowledge of life phenomena. Due to the extreme magnitude of this challenge, in the current article, I tried to summarize the current knowledge about fundamental life processes, i.e., energy and information metabolism, and, thus, initiate a broader discussion about the life and future of our species.

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来源期刊
Metabolites
Metabolites Biochemistry, Genetics and Molecular Biology-Molecular Biology
CiteScore
5.70
自引率
7.30%
发文量
1070
审稿时长
17.17 days
期刊介绍: Metabolites (ISSN 2218-1989) is an international, peer-reviewed open access journal of metabolism and metabolomics. Metabolites publishes original research articles and review articles in all molecular aspects of metabolism relevant to the fields of metabolomics, metabolic biochemistry, computational and systems biology, biotechnology and medicine, with a particular focus on the biological roles of metabolites and small molecule biomarkers. Metabolites encourages scientists to publish their experimental and theoretical results in as much detail as possible. Therefore, there is no restriction on article length. Sufficient experimental details must be provided to enable the results to be accurately reproduced. Electronic material representing additional figures, materials and methods explanation, or supporting results and evidence can be submitted with the main manuscript as supplementary material.
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