Tobias Krickau, Joachim Woelfle, Michael Beck, Torsten Kuwert, Christian Schmidkonz, Klaus Engel, Armin Atzinger
{"title":"68Ga-FAPI-46 PET/CT诊断青少年系统性硬化症脏器受累","authors":"Tobias Krickau, Joachim Woelfle, Michael Beck, Torsten Kuwert, Christian Schmidkonz, Klaus Engel, Armin Atzinger","doi":"10.2967/jnmt.125.269645","DOIUrl":null,"url":null,"abstract":"<p><p>We sought to assess the diagnostic value of <sup>68</sup>Ga-fibroblast activation protein inhibitor (FAPI)-46 PET/CT for obtaining information on organ involvement in the process of inflammation and fibrosis in patients with juvenile systemic sclerosis (jSSc). <b>Methods:</b> In this retrospective study, 4 children with a diagnosis of jSSc underwent <sup>68</sup>Ga-FAPI-46 PET/CT imaging, 3 immediately after the diagnosis and before implementing immunmodulatory drugs and 1 a few years after active disease. <b>Results:</b> In this case series, <sup>68</sup>Ga-FAPI-46 PET/CT detected all clinically known organ manifestations of jSSc. Additionally, this diagnostic tool provided previously unknown information about cardiac and muscular involvement in jSSc. <b>Conclusion:</b> <sup>68</sup>Ga-FAPI-46 PET/CT provides valuable information to better assess disease activity and detect organ involvement. Further studies using <sup>68</sup>Ga-FAPI-46 PET/CT in patients with jSSc are encouraged.</p>","PeriodicalId":16548,"journal":{"name":"Journal of nuclear medicine technology","volume":" ","pages":""},"PeriodicalIF":1.0000,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Diagnosing Organ Involvement in Juvenile Systemic Sclerosis with <sup>68</sup>Ga-FAPI-46 PET/CT.\",\"authors\":\"Tobias Krickau, Joachim Woelfle, Michael Beck, Torsten Kuwert, Christian Schmidkonz, Klaus Engel, Armin Atzinger\",\"doi\":\"10.2967/jnmt.125.269645\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>We sought to assess the diagnostic value of <sup>68</sup>Ga-fibroblast activation protein inhibitor (FAPI)-46 PET/CT for obtaining information on organ involvement in the process of inflammation and fibrosis in patients with juvenile systemic sclerosis (jSSc). <b>Methods:</b> In this retrospective study, 4 children with a diagnosis of jSSc underwent <sup>68</sup>Ga-FAPI-46 PET/CT imaging, 3 immediately after the diagnosis and before implementing immunmodulatory drugs and 1 a few years after active disease. <b>Results:</b> In this case series, <sup>68</sup>Ga-FAPI-46 PET/CT detected all clinically known organ manifestations of jSSc. Additionally, this diagnostic tool provided previously unknown information about cardiac and muscular involvement in jSSc. <b>Conclusion:</b> <sup>68</sup>Ga-FAPI-46 PET/CT provides valuable information to better assess disease activity and detect organ involvement. Further studies using <sup>68</sup>Ga-FAPI-46 PET/CT in patients with jSSc are encouraged.</p>\",\"PeriodicalId\":16548,\"journal\":{\"name\":\"Journal of nuclear medicine technology\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":1.0000,\"publicationDate\":\"2025-06-24\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of nuclear medicine technology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.2967/jnmt.125.269645\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of nuclear medicine technology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2967/jnmt.125.269645","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING","Score":null,"Total":0}
Diagnosing Organ Involvement in Juvenile Systemic Sclerosis with 68Ga-FAPI-46 PET/CT.
We sought to assess the diagnostic value of 68Ga-fibroblast activation protein inhibitor (FAPI)-46 PET/CT for obtaining information on organ involvement in the process of inflammation and fibrosis in patients with juvenile systemic sclerosis (jSSc). Methods: In this retrospective study, 4 children with a diagnosis of jSSc underwent 68Ga-FAPI-46 PET/CT imaging, 3 immediately after the diagnosis and before implementing immunmodulatory drugs and 1 a few years after active disease. Results: In this case series, 68Ga-FAPI-46 PET/CT detected all clinically known organ manifestations of jSSc. Additionally, this diagnostic tool provided previously unknown information about cardiac and muscular involvement in jSSc. Conclusion:68Ga-FAPI-46 PET/CT provides valuable information to better assess disease activity and detect organ involvement. Further studies using 68Ga-FAPI-46 PET/CT in patients with jSSc are encouraged.
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