多次玻璃体内注射相关的角膜内皮细胞改变。

IF 0.9 Q3 OPHTHALMOLOGY
Journal of Current Ophthalmology Pub Date : 2025-02-06 eCollection Date: 2024-07-01 DOI:10.4103/joco.joco_26_23
Mariaelena Malvasi, Pietro Mangiantini, Floriana Testa, Edoardo Trovato Battagliola, Mattia D'Andrea, Guglielmo Minozzi, Paolo Turchetti, Elena Pacella
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引用次数: 0

摘要

目的:探讨抗血管内皮生长因子(anti-VEGF)或类固醇注射治疗后段病变患者角膜内皮的变化。方法:本横断面研究招募了接受玻璃体内抗vegf或缓释地塞米松治疗视网膜静脉阻塞引起的黄斑水肿的受试者。用角膜内皮显微镜测量治疗眼的角膜内皮和角膜厚度。研究变量包括年龄、内皮细胞密度(ECD)、细胞大小变异系数(CV)、六边形百分比(HEX%)、注射后30min眼内压(IOP)变化。对这些变量进行多元线性回归分析。结果:在2020年1月至2023年12月期间,共有108只患病的眼睛接受了玻璃体内注射,数量不等(从4到28)。平均总玻璃体内注射次数为12.8次/眼。多元线性回归分析显示,ECD与年龄(β = -9.74, 95%可信区间[CI] [-8.01, -10.24], P < 0.05)和总注射次数(β = -17.11, 95% CI [-16.44, -18.37], P < 0.05)呈负相关。HEX%与年龄(β = -0.17, 95% CI [-0.11, -0.23], P < 0.05)和总注射次数(β = -0.45, 95% CI [-0.37, -0.54], P < 0.05)呈负相关。CV与年龄(β =0.29, 95% CI [0.19, 0.40], P < 0.05)和总注射次数(β =0.54, 95% CI [0.45, 0.63], P < 0.05)有直接关系。注射后30min注射眼与对侧眼的平均IOP差值为+6.4±3 mmHg (P < 0.05)。结论:较多的玻璃体内注射与较低的ECD、较低的HEX和较高的CV有关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Corneal Endothelial Cell Changes Associated with Multiple Intravitreal Injections.

Purpose: To explore the changes in the corneal endothelium in patients who receive multiple anti-vascular endothelial growth factor (anti-VEGF) or steroid injections for posterior segment pathology.

Methods: This cross-sectional study recruits subjects treated with intravitreal anti-VEGF or sustained-release dexamethasone for macular edema due to retinal vein occlusion. Corneal endothelium and corneal thickness were measured in the treated eye using a corneal endothelial microscope. The study variables include age, endothelial cell density (ECD), coefficient of variation (CV) of cell size, percentage of hexagonality (HEX%), and intraocular pressure (IOP) change 30 min after injection. These variables were analyzed using multiple linear regression analysis.

Results: A total of 108 diseased eyes were treated with a variable number (from 4 to 28) of intravitreal injections between January 2020 and December 2023. The mean total number of intravitreal injections was 12.8/eye. Multiple linear regression analysis showed an inverse relationship between ECD and age (β = -9.74, 95% confidence interval [CI] [-8.01, -10.24], P < 0.05) and total number of injections (β = -17.11, 95% CI [-16.44, -18.37], P < 0.05). An inversion relationship also exists between HEX% and age (β = -0.17, 95% CI [-0.11, -0.23], P < 0.05) and total number of injections (β = -0.45, 95% CI [-0.37, -0.54], P < 0.05). A direct relationship exists between CV and age (β =0.29, 95% CI [0.19, 0.40], P < 0.05) and total number of injections (β =0.54, 95% CI [0.45, 0.63], P < 0.05). The mean IOP difference between the injected and contralateral eye 30 min postinjection was +6.4 ± 3 mmHg (P < 0.05).

Conclusion: A greater number of intravitreal injections is associated with a lower ECD, lower HEX, and higher CV in the treated eyes.

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来源期刊
CiteScore
2.50
自引率
6.70%
发文量
45
审稿时长
8 weeks
期刊介绍: Peer Review under the responsibility of Iranian Society of Ophthalmology Journal of Current Ophthalmology, the official publication of the Iranian Society of Ophthalmology, is a peer-reviewed, open-access, scientific journal that welcomes high quality original articles related to vision science and all fields of ophthalmology. Journal of Current Ophthalmology is the continuum of Iranian Journal of Ophthalmology published since 1969.
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