二尖瓣环钙化,一个不像我们许多人认为的那样边缘和相对良性的发现:综述。

IF 2.4 4区 医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS
András Vereckei, Zsigmond Jenei, Hajnalka Vágó, Dorottya Balla, Alexisz Panajotu, Andrea Nagy, Gábor Katona
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引用次数: 0

摘要

二尖瓣环形钙化(MAC)通常被认为是偶然的、良性的、与年龄相关的发现,在心血管或肺部疾病的影像学检查中没有严重的并发症,严重时可能导致二尖瓣反流或狭窄。因此,它通常不被认为是一个重大的改变。然而,越来越多的证据表明,它与心血管事件的高风险相关,如动脉粥样硬化性冠状动脉疾病、主动脉疾病、颈动脉疾病、外周动脉疾病、中风、心房颤动、房室和/或室内传导障碍、全身栓塞、感染性心内膜炎、心力衰竭和死亡率。MAC的存在也显著影响二尖瓣经导管和手术干预的结果。几种情况可诱发MAC。MAC与心血管危险因素密切相关,如高血压、糖尿病、吸烟和心血管动脉粥样硬化,炎症也可能在MAC的发病机制中发挥作用。此外,增加二尖瓣压力的情况,如高血压、主动脉瓣狭窄和肥厚性心肌病,易导致二尖瓣环区域退行性钙化加速。先天性疾病,如Marfan综合征和Hurler综合征,也与MAC有关,因为构成环的结缔组织的内在异常。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Mitral Annular Calcification, a Not So Marginal and Relatively Benign Finding as Many of Us Think: A Review.

Mitral annular calcification (MAC) is usually considered an incidental, benign, age-related finding without serious complications in patients evaluated for cardiovascular or pulmonary disease with imaging studies that may result in mitral regurgitation or stenosis when severe. Therefore, it is usually not considered a significant alteration. However, there is accumulating evidence that it is associated with a higher risk of cardiovascular events, such as atherosclerotic coronary artery disease, aortic artery disease, carotid artery disease, peripheral artery disease, stroke, atrial fibrillation, atrioventricular and/or intraventricular conduction disturbance, systemic embolization, infective endocarditis, heart failure and mortality. The presence of MAC also significantly influences the outcome of mitral valve transcatheter and surgical interventions. Several conditions may predispose to MAC. MAC is strongly related to cardiovascular risk factors, such as hypertension, diabetes, smoking and cardiovascular atherosclerosis, and inflammation may also play a role in the pathogenesis of MAC. Also, conditions that increase mitral valve stress, such as hypertension, aortic stenosis and hypertrophic cardiomyopathy, predispose to accelerated degenerative calcification of the mitral annulus area. Congenital disorders, e.g., Marfan syndrome and Hurler syndrome, are also associated with MAC, due to an intrinsic abnormality of the connective tissue composing the annulus.

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来源期刊
Journal of Cardiovascular Development and Disease
Journal of Cardiovascular Development and Disease CARDIAC & CARDIOVASCULAR SYSTEMS-
CiteScore
2.60
自引率
12.50%
发文量
381
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