他汀类药物用于表面健康成人心血管疾病的一级预防

IF 8.4 2区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS
Andrim Halili, Talip E Eroglu, Christian Torp-Pedersen, Bochra Zareini
{"title":"他汀类药物用于表面健康成人心血管疾病的一级预防","authors":"Andrim Halili, Talip E Eroglu, Christian Torp-Pedersen, Bochra Zareini","doi":"10.1093/eurjpc/zwaf357","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>To study the association between statin adherence and the 5-year risk of major cardiovascular events among apparently healthy individuals.</p><p><strong>Methods and results: </strong>A nationwide cohort study utilising national registries in Denmark was conducted. All apparently healthy individuals aged 40-85 years using statins for one year between 1997 and 2022 with no personal history of cardiovascular diseases, diabetes mellitus, chronic obstructive pulmonary disease, hepatic diseases, cancer, or parents with cardiovascular disease, among other exclusion factors, were included. Statin use was categorized according to adherence by the proportion of days covered with redeemed statin prescriptions: <50% (low), 50-75% (moderate), and 75-100% (high). The primary outcome was a composite of myocardial infarction, stroke, or cardiovascular death. The 5-year absolute risk was estimated using the Aalen-Johansen estimator while considering competing risks. Additionally, cause-specific Cox proportional hazards models were used to estimate hazard ratios across statin adherence levels.Among 151,791 apparently healthy individuals, low statin adherence was associated with a 5-year major cardiovascular risk of 4.77% (95%-confidence interval 4.18-5.36). For moderate adherence, the 5-year risk was 3.71% (95%-confidence interval 4.18-5.36), and the corresponding hazard ratio was 0.87 (95%-confidence interval 0.75-1.01), while high adherence was associated with the lowest 5-year risk of 3.01% (95%-confidence interval 2.90-3.11), and the corresponding hazard ratio was 0.66 (95%-confidence interval 0.58-0.75).</p><p><strong>Conclusion: </strong>High statin adherence among apparently healthy users was associated with a significant risk reduction of major cardiovascular adverse events.</p>","PeriodicalId":12051,"journal":{"name":"European journal of preventive cardiology","volume":" ","pages":""},"PeriodicalIF":8.4000,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Statin use for primary prevention of cardiovascular disease among apparently healthy adults.\",\"authors\":\"Andrim Halili, Talip E Eroglu, Christian Torp-Pedersen, Bochra Zareini\",\"doi\":\"10.1093/eurjpc/zwaf357\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>To study the association between statin adherence and the 5-year risk of major cardiovascular events among apparently healthy individuals.</p><p><strong>Methods and results: </strong>A nationwide cohort study utilising national registries in Denmark was conducted. All apparently healthy individuals aged 40-85 years using statins for one year between 1997 and 2022 with no personal history of cardiovascular diseases, diabetes mellitus, chronic obstructive pulmonary disease, hepatic diseases, cancer, or parents with cardiovascular disease, among other exclusion factors, were included. Statin use was categorized according to adherence by the proportion of days covered with redeemed statin prescriptions: <50% (low), 50-75% (moderate), and 75-100% (high). The primary outcome was a composite of myocardial infarction, stroke, or cardiovascular death. The 5-year absolute risk was estimated using the Aalen-Johansen estimator while considering competing risks. Additionally, cause-specific Cox proportional hazards models were used to estimate hazard ratios across statin adherence levels.Among 151,791 apparently healthy individuals, low statin adherence was associated with a 5-year major cardiovascular risk of 4.77% (95%-confidence interval 4.18-5.36). For moderate adherence, the 5-year risk was 3.71% (95%-confidence interval 4.18-5.36), and the corresponding hazard ratio was 0.87 (95%-confidence interval 0.75-1.01), while high adherence was associated with the lowest 5-year risk of 3.01% (95%-confidence interval 2.90-3.11), and the corresponding hazard ratio was 0.66 (95%-confidence interval 0.58-0.75).</p><p><strong>Conclusion: </strong>High statin adherence among apparently healthy users was associated with a significant risk reduction of major cardiovascular adverse events.</p>\",\"PeriodicalId\":12051,\"journal\":{\"name\":\"European journal of preventive cardiology\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":8.4000,\"publicationDate\":\"2025-06-24\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"European journal of preventive cardiology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1093/eurjpc/zwaf357\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CARDIAC & CARDIOVASCULAR SYSTEMS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"European journal of preventive cardiology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1093/eurjpc/zwaf357","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CARDIAC & CARDIOVASCULAR SYSTEMS","Score":null,"Total":0}
引用次数: 0

摘要

目的:研究他汀类药物依从性与表面健康个体5年主要心血管事件风险的关系。方法和结果:在丹麦进行了一项利用国家登记处的全国性队列研究。所有年龄在40-85岁之间,在1997年至2022年期间使用他汀类药物一年,且没有心血管疾病、糖尿病、慢性阻塞性肺病、肝脏疾病、癌症或父母患有心血管疾病的个人,以及其他排除因素,被纳入研究。他汀类药物的使用根据坚持使用他汀类药物的天数比例进行分类:结论:在表面健康的他汀类药物使用者中,高度坚持使用他汀类药物与主要心血管不良事件的显著降低相关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Statin use for primary prevention of cardiovascular disease among apparently healthy adults.

Objective: To study the association between statin adherence and the 5-year risk of major cardiovascular events among apparently healthy individuals.

Methods and results: A nationwide cohort study utilising national registries in Denmark was conducted. All apparently healthy individuals aged 40-85 years using statins for one year between 1997 and 2022 with no personal history of cardiovascular diseases, diabetes mellitus, chronic obstructive pulmonary disease, hepatic diseases, cancer, or parents with cardiovascular disease, among other exclusion factors, were included. Statin use was categorized according to adherence by the proportion of days covered with redeemed statin prescriptions: <50% (low), 50-75% (moderate), and 75-100% (high). The primary outcome was a composite of myocardial infarction, stroke, or cardiovascular death. The 5-year absolute risk was estimated using the Aalen-Johansen estimator while considering competing risks. Additionally, cause-specific Cox proportional hazards models were used to estimate hazard ratios across statin adherence levels.Among 151,791 apparently healthy individuals, low statin adherence was associated with a 5-year major cardiovascular risk of 4.77% (95%-confidence interval 4.18-5.36). For moderate adherence, the 5-year risk was 3.71% (95%-confidence interval 4.18-5.36), and the corresponding hazard ratio was 0.87 (95%-confidence interval 0.75-1.01), while high adherence was associated with the lowest 5-year risk of 3.01% (95%-confidence interval 2.90-3.11), and the corresponding hazard ratio was 0.66 (95%-confidence interval 0.58-0.75).

Conclusion: High statin adherence among apparently healthy users was associated with a significant risk reduction of major cardiovascular adverse events.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
European journal of preventive cardiology
European journal of preventive cardiology CARDIAC & CARDIOVASCULAR SYSTEMS-
CiteScore
12.50
自引率
12.00%
发文量
601
审稿时长
3-8 weeks
期刊介绍: European Journal of Preventive Cardiology (EJPC) is an official journal of the European Society of Cardiology (ESC) and the European Association of Preventive Cardiology (EAPC). The journal covers a wide range of scientific, clinical, and public health disciplines related to cardiovascular disease prevention, risk factor management, cardiovascular rehabilitation, population science and public health, and exercise physiology. The categories covered by the journal include classical risk factors and treatment, lifestyle risk factors, non-modifiable cardiovascular risk factors, cardiovascular conditions, concomitant pathological conditions, sport cardiology, diagnostic tests, care settings, epidemiology, pharmacology and pharmacotherapy, machine learning, and artificial intelligence.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信