Je-Won Yoo, Chaerin Park, Hyesung Lee, Youn-Ha Lee, Young-Mi Lee
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引用次数: 0
摘要
越来越多地使用防晒霜来保护人类皮肤免受UV-A和UV-B的伤害，这是海洋生态系统中一个令人担忧的问题。然而，防晒产品对海洋生物群的毒性目前尚不清楚。因此，我们研究了根据配方选择的四种商业防晒霜（A-D）对苦咸水蚤（Diaphanosoma celebensis）的生存、繁殖、能量代谢和抗氧化系统的毒性影响。产品C和产品D的48 h中位致死浓度（48 h LC50）分别为57.22%和43.59%。在与环境相关的浓度下，产物D破坏了繁殖并缩短了体长。虽然在能量储备方面没有观察到显著差异，但AMPK基因在固体产品C和d中被高度调节，所有实验组的SOD活性都显著增加，暴露于产品C和d的组的CAT表达上调。我们的研究结果表明，商业防晒霜通过破坏氧化还原和能量稳态，对生殖毒性具有配方依赖性。
Effects of sunscreens on survival, reproduction, energy metabolism, and antioxidant system of brackish water flea Diaphanosoma celebensis.
The increasing use of sunscreen to protect human skin from UV-A and UV-B is a great concern in the marine ecosystem. However, the toxicity of sunscreen products on marine biota is currently unclear. Thus, we investigated the toxic effects of four commercial sunscreens (A-D) selected according to the formulation on the survival, reproduction, energy metabolism, and antioxidant system of the brackish water flea Diaphanosoma celebensis. The 48 h median lethal concentrations (48-h LC50) of sunscreen extracts were determined as 57.22%, and 43.59% in product C and product D, respectively. At the environmentally relevant concentrations, product D disrupted reproduction and reduced body length. Although no significant differences in energy reserves were observed, AMPK genes were highly modulated in the solid products C and D. SOD activity was significantly increased in all experimental groups, and the expression of CAT was up-regulated in groups exposed to products C and D. Our results imply that commercial sunscreens have a formulation-dependent effect on reproductive toxicity by disrupting redox and energy homeostasis.
期刊介绍：
Ecotoxicology is an international journal devoted to the publication of fundamental research on the effects of toxic chemicals on populations, communities and terrestrial, freshwater and marine ecosystems. It aims to elucidate mechanisms and processes whereby chemicals exert their effects on ecosystems and the impact caused at the population or community level. The journal is not biased with respect to taxon or biome, and papers that indicate possible new approaches to regulation and control of toxic chemicals and those aiding in formulating ways of conserving threatened species are particularly welcome. Studies on individuals should demonstrate linkage to population effects in clear and quantitative ways. Laboratory studies must show a clear linkage to specific field situations. The journal includes not only original research papers but technical notes and review articles, both invited and submitted. A strong, broadly based editorial board ensures as wide an international coverage as possible.
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