γδ T细胞在肿瘤细胞识别中的作用机制

IF 3.4 4区 医学 Q2 ONCOLOGY
Jing Tang, Chen Wu, Jintong Na, Yamin Deng, Simin Qin, Liping Zhong, Yongxiang Zhao
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引用次数: 0

摘要

γδ T细胞是免疫系统的第一道防线之一,在连接先天免疫和适应性免疫中起着至关重要的作用。虽然γδ T细胞对肿瘤免疫监视至关重要,但γδ T细胞受体在靶细胞中识别分子靶标的完整机制尚不清楚。靶细胞可通过甲羟戊酸途径或甲基赤藓糖醇磷酸途径产生磷酸抗原(PAgs)。BTN3A1-BTN2A1复合物与PAgs结合后,其胞外结构域发生构象变化,导致v γ - 9v - δ2 T细胞识别。然而,关于v γ - 9v - δ2 T细胞如何识别这种复合物的变化的结构基础仍然是难以捉摸的。本文就Vγ9Vδ2 T细胞识别和靶向肿瘤细胞的历史进展和最新发现作一综述。我们还讨论了γδ T细胞免疫治疗的潜力及其作为抗肿瘤药物的作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Mechanisms and Functions of γδ T Cells in Tumor Cell Recognition.

γδ T cells are among the first line of defense in the immune system, playing a crucial role in bridging innate and adaptive immunity. Although γδ T cells are crucial for tumor immune surveillance, the complete mechanism by which γδ T cell receptors identify molecular targets in target cells remains unknown. Target cells can produce phosphoantigens (PAgs) via the mevalonate pathway or the methylerythritol phosphate pathway. The BTN3A1-BTN2A1 complex undergoes conformational changes in its extracellular domains upon binding to PAgs, leading to Vγ9Vδ2 T cell recognition. However, the structural basis of how Vγ9Vδ2 T cells recognize changes in this complex remains elusive. This review provides a detailed overview of the historical progress and recent discoveries regarding how Vγ9Vδ2 T cells recognize and target tumor cells. We also discuss the potential of γδ T cells immunotherapy and their role as antitumor agents.

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来源期刊
Current oncology
Current oncology ONCOLOGY-
CiteScore
3.30
自引率
7.70%
发文量
664
审稿时长
1 months
期刊介绍: Current Oncology is a peer-reviewed, Canadian-based and internationally respected journal. Current Oncology represents a multidisciplinary medium encompassing health care workers in the field of cancer therapy in Canada to report upon and to review progress in the management of this disease. We encourage submissions from all fields of cancer medicine, including radiation oncology, surgical oncology, medical oncology, pediatric oncology, pathology, and cancer rehabilitation and survivorship. Articles published in the journal typically contain information that is relevant directly to clinical oncology practice, and have clear potential for application to the current or future practice of cancer medicine.
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