Jingxuan Wang, Erin L Ferguson, Peter Buto, Ruijia Chen, Anna Pederson, Minhyuk Choi, Andrew C Stokes, Deborah Blacker, M Maria Glymour
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引用次数: 0
摘要
庞大而多样的“我们所有人”研究项目为健康研究提供了巨大的机会。然而,由于该计划的目标招聘努力,结果可能无法推广到美国人口。我们将所有参与者与1999-2018年全国代表性连续国家健康与营养检查调查(NHANES)的参与者进行了比较,其中包括:总体死亡率;社会人口、健康相关和临床特征的分布;每个特征与使用Cox比例风险模型估计的死亡率的关联;以及每个特征和死亡率的群体归因分数(PAFs)。与NHANES相比,我们所有的参与者年龄较大,非西班牙裔白人的可能性较小,受教育年限更长,主要慢性疾病的患病率更高。所有参与者的死亡率普遍较低,尤其是老年人。All of Us和NHANES的关联方向在几乎所有的比较中都是一致的,但在某些情况下,主要是临床诊断,其程度不同。我们所有人的paf普遍较高。我们所有人的死亡率预测指标并不一致地适用于美国人口。需要分析方法来解决非代表性问题,并减轻与选择进入我们所有人队列相关的潜在偏见。
Sociodemographic, health-related, and clinical characteristics and their associations with mortality among all of us participants compared with the United States general population.
The large and diverse All of Us Research Program offers tremendous opportunities for health research. However, results may not be generalizable to the U.S. population due to the program's targeted recruitment efforts. We compared All of Us participants to those from the nationally representative continuous 1999-2018 National Health and Nutrition Examination Survey (NHANES) with respect to: overall mortality rates; the distribution of sociodemographic, health-related, and clinical characteristics; the association of each characteristic with mortality estimated using Cox proportional-hazards models; and population attributable fractions (PAFs) for each characteristic and mortality. All of Us participants were older, less likely to be Non-Hispanic White, had more years of education, and had a higher prevalence of major chronic conditions than NHANES. Mortality rates were generally lower for All of Us participants, especially at older ages. The direction of associations in All of Us and NHANES matched for almost all comparisons, but differed in magnitude for some conditions, primarily clinical diagnoses. PAFs were generally higher in All of Us. Predictors of mortality in All of Us do not consistently generalize to the U.S. population. Analytical approaches are needed to address non-representativeness and mitigate potential biases associated with the selection into the All of Us cohort.
期刊介绍:
The American Journal of Epidemiology is the oldest and one of the premier epidemiologic journals devoted to the publication of empirical research findings, opinion pieces, and methodological developments in the field of epidemiologic research.
It is a peer-reviewed journal aimed at both fellow epidemiologists and those who use epidemiologic data, including public health workers and clinicians.