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十字路口的钙：TPC2在lrrk2相关帕金森病中的作用

IF 4 2区 生物学 Q2 CELL BIOLOGY
Cell calcium Pub Date : 2025-06-17 DOI:10.1016/j.ceca.2025.103049
Federica De Lazzari , Simone Wanderoy , Alexander J Whitworth
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引用次数: 0

摘要

LRRK2的致病机制一直备受争议，但对溶酶体稳态的调节已成为一个主要的焦点领域。在最近的工作中，Gregori等人表明，通过溶酶体双孔通道2 （TPC2）释放Ca2+可能是多巴胺能神经元易感性的一个重要因素。
本文章由计算机程序翻译，如有差异，请以英文原文为准。

Calcium at the crossroads: TPC2’s role in LRRK2-linked Parkinson’s disease

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Calcium at the crossroads: TPC2’s role in LRRK2-linked Parkinson’s disease
The pathogenic mechanisms of LRRK2 are hotly debated but regulation of lysosomal homeostasis has emerged as a leading focus area. In recent work, Gregori et al. show that Ca2+ release through the lysosomal Two-Pore Channel 2 (TPC2) could be a significant contributor to dopaminergic neuron vulnerability.
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来源期刊
Cell calcium
Cell calcium 生物-细胞生物学
CiteScore
8.70
自引率
5.00%
发文量
115
审稿时长
35 days
期刊介绍： Cell Calcium covers the field of calcium metabolism and signalling in living systems, from aspects including inorganic chemistry, physiology, molecular biology and pathology. Topic themes include: Roles of calcium in regulating cellular events such as apoptosis, necrosis and organelle remodelling Influence of calcium regulation in affecting health and disease outcomes
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