美国25岁及以上心力衰竭患者与心源性休克相关的死亡率趋势：一项利用1999年至2023年CDC WONDER数据库的研究

IF 2.5 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

IJC Heart and Vasculature Pub Date : 2025-06-26 DOI:10.1016/j.ijcha.2025.101732

Abdullah Naveed Muhammad , Sivaram Neppala , Himaja Dutt Chigurupati , Muhammad Omer Rehan , Hamza Naveed , Rabia Iqbal , Bazil Azeem , Ahila Ali , Mushood Ahmed , Prakash Upreti , Mobeen Zaka Haider , Yasar Sattar , Jamal S. Rana , Gregg C. Fonarow

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引用次数: 0

摘要

背景：心源性休克（CS）仍然是心衰（HF）患者死亡率的关键因素。然而，与CS相关的长期死亡率趋势的当代数据有限。本研究调查了25岁以上HF患者CS死亡率的人口统计学模式和趋势。方法数据来自疾病控制和预防中心广泛的流行病学研究在线数据（CDC WONDER）数据库（1999-2023），包括年龄≥25岁诊断为HF和CS的成年人。采用Joinpoint回归分析每10万人的年龄调整死亡率（AAMRs）及其趋势，找出平均年变化百分比（AAPC）和年变化百分比（APC）。结果1999年至2023年间，心力衰竭患者中有108,514例死亡与心源性休克有关，aamr从1.2 / 10万增加到4.6 / 10万（AAPC: 5.90）。增幅最大的是2009年至2021年（APC: 14.17），其次是2021年至2023年的持续增长（APC: 7.83）。男性的aamr始终高于女性（2.4比1.3），黑人的死亡率在所有种族和族裔群体中最高。此外，农村地区的死亡率明显高于城市地区（1.7比1.5）。结论在过去的25年中，心衰患者cs相关的死亡率增加了近4倍。这一趋势突出表明有必要调查其原因，包括可能恶化的健康结果或改善的医疗保健机会。应特别关注高危人群，如男性、黑人和农村居民，因为有针对性的干预措施可以减轻差异并提高结果。

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Mortality trends related to cardiogenic shock in heart failure patients aged 25 and older across the United States: A study utilizing the CDC WONDER database from 1999 to 2023

Background

Cardiogenic shock (CS) remains crucial in mortality rates for heart failure (HF) patients. However, contemporary data on long-term mortality trends related to CS are limited. This study investigates demographic patterns and trends in CS mortality among HF patients over 25 years.

Methods

Data from the Centers for Disease Control and Prevention’s Wide-ranging Online Data for Epidemiologic Research (CDC WONDER) database (1999–2023) included adults aged ≥25 diagnosed with HF and CS. Age-adjusted mortality rates (AAMRs) per 100,000 population and trends were analyzed using Joinpoint regression to find the average annual percent change (AAPC) and annual percent change (APC).

Results

Between 1999 and 2023, there were 108,514 deaths linked to cardiogenic shock among heart failure patients, with AAMRs increasing from 1.2 to 4.6 per 100,000 (AAPC: 5.90). The most significant increases occurred from 2009 to 2021 (APC: 14.17), followed by a sustained rise from 2021 to 2023 (APC: 7.83). Men consistently exhibited higher AAMRs than women (2.4 vs. 1.3), and Black individuals had the highest mortality rates across all racial and ethnic groups. Furthermore, mortality rates were notably higher in rural areas compared to urban settings (1.7 vs. 1.5).

Conclusion

In the past 25 years, CS-related mortality in HF patients has increased nearly fourfold. This trend highlights the need to investigate its causes, including potential deteriorating health outcomes or improved healthcare access. Special focus should be on high-risk groups like men, Black individuals, and rural residents, as targeted interventions could mitigate disparities and enhance outcomes.

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来源期刊

IJC Heart and Vasculature Medicine-Cardiology and Cardiovascular Medicine

CiteScore

4.90

自引率

10.30%

发文量

216

审稿时长

56 days

期刊介绍： IJC Heart & Vasculature is an online-only, open-access journal dedicated to publishing original articles and reviews (also Editorials and Letters to the Editor) which report on structural and functional cardiovascular pathology, with an emphasis on imaging and disease pathophysiology. Articles must be authentic, educational, clinically relevant, and original in their content and scientific approach. IJC Heart & Vasculature requires the highest standards of scientific integrity in order to promote reliable, reproducible and verifiable research findings. All authors are advised to consult the Principles of Ethical Publishing in the International Journal of Cardiology before submitting a manuscript. Submission of a manuscript to this journal gives the publisher the right to publish that paper if it is accepted. Manuscripts may be edited to improve clarity and expression.