控制碳正离子

IF 44.6 1区化学 Q1 CHEMISTRY, PHYSICAL

Nature Catalysis Pub Date : 2025-06-25 DOI:10.1038/s41929-025-01378-7

Francesco Zamberlan

引用次数: 0

摘要

现在，Marek和他的同事们在《美国化学学会杂志》上发表了一篇文章，报告了环丙基羰基中间体是如何引起同丙烯醇的立体保持性亲核取代的。事实上，化合物1的叔醇，与烯丙基叔碳立体中心相邻，可以被路易斯酸激活，形成所需的CPC A，其正电荷定位在C4上，然后亲核试剂攻击以提供2。研究小组首先通过同丙烯醇与氟亲核试剂DAST （Et2NSF3）反应证明了这种转化，从而产生相应的叔烷基氟，收率高，非对映比高；改变醇中心的立体化学结构可以得到另一种非对映体。这组研究人员还分别用TMSBr和TMSCl探索了溴化和氯化；fecl3催化的TMSN3叠氮化反应；用TMSNCS进行硫氰化处理，得到相应的同丙烯基化合物。该方法对R4上的芳香取代基以及R3和R5上的其他线性基团和官能团具有较高的耐受性，但更局限于R2和R1上的短烷基链。尽管如此，其整体的通用性和精确的非对映选择性将使其在方法上得到采用，同时进一步展示sn1型反应性在区域和立体选择性转化中的效用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Controlling carbocations

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Controlling carbocations

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来源期刊

Nature Catalysis Chemical Engineering-Bioengineering

CiteScore

52.10

自引率

1.10%

发文量

140

期刊介绍： Nature Catalysis serves as a platform for researchers across chemistry and related fields, focusing on homogeneous catalysis, heterogeneous catalysis, and biocatalysts, encompassing both fundamental and applied studies. With a particular emphasis on advancing sustainable industries and processes, the journal provides comprehensive coverage of catalysis research, appealing to scientists, engineers, and researchers in academia and industry. Maintaining the high standards of the Nature brand, Nature Catalysis boasts a dedicated team of professional editors, rigorous peer-review processes, and swift publication times, ensuring editorial independence and quality. The journal publishes work spanning heterogeneous catalysis, homogeneous catalysis, and biocatalysis, covering areas such as catalytic synthesis, mechanisms, characterization, computational studies, nanoparticle catalysis, electrocatalysis, photocatalysis, environmental catalysis, asymmetric catalysis, and various forms of organocatalysis.