Zimu Wu, Alice Owen, Robyn L Woods, Zhen Zhou, Trevor T-J Chong, Suzanne G Orchard, Raj C Shah, Kerry M Sheets, Anne M Murray, Joanne Ryan
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Cox and mixed-effects models were used to examine the associations with dementia and cognitive change.</p><p><strong>Results: </strong>WBR was positively associated with dementia (Q4 versus Q1, hazard ratio [HR]: 1.29, <i>p</i> = 0.004) and cognitive decline (coefficients:-0.122 to -0.025, <i>p</i> < 0.05). Dementia risk was 15% to 38% lower for individuals in higher quartiles of LBM and FBM (Q2 to Q4), compared to Q1 (<i>p</i> < 0.05). 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引用次数: 0
摘要
前言：本研究探讨了腰围-体重指数比（WBR）、瘦体重（LBM）和脂肪体重（FBM）是否与痴呆或认知变化相关。方法：我们分析了入组时年龄在65岁至98岁之间的bb17000人的数据。LBM和FBM用休谟方程估计。痴呆根据DSM-IV进行诊断。整体认知、语言流畅性、情景记忆和精神运动速度被评估了11年。使用Cox和混合效应模型来检查与痴呆和认知变化的关系。结果：WBR与痴呆（Q4 vs Q1，危险比[HR]: 1.29, p = 0.004）和认知能力下降（系数：-0.122 ~ -0.025,p p p p）呈正相关。讨论：晚年较高的LBM和FBM可能与更好的认知能力相关，而腹部脂肪可能是一个危险因素。重点：较高的WBR与较高的痴呆风险相关，仅在男性中存在。WBR越高，认知能力下降越快。较大的LBM和FBM与较低的痴呆风险相关。更大的LBM和FBM与较慢的认知衰退有关。中枢性肥胖可能是老年人认知障碍的一个危险因素。
Associations of abdominal adiposity, lean body mass, and fat body mass with dementia and cognitive change in older age.
Introduction: This study examined whether the waist circumference-body mass index ratio (WBR), lean body mass (LBM), and fat body mass (FBM) were associated with dementia or cognitive change.
Methods: We analyzed data from >17,000 individuals aged 65 to 98 years at enrollment. LBM and FBM were estimated using the Hume equation. Dementia was determined according to DSM-IV. Global cognition, verbal fluency, episodic memory, and psychomotor speed were assessed across 11 years. Cox and mixed-effects models were used to examine the associations with dementia and cognitive change.
Results: WBR was positively associated with dementia (Q4 versus Q1, hazard ratio [HR]: 1.29, p = 0.004) and cognitive decline (coefficients:-0.122 to -0.025, p < 0.05). Dementia risk was 15% to 38% lower for individuals in higher quartiles of LBM and FBM (Q2 to Q4), compared to Q1 (p < 0.05). Higher LBM and FBM were associated with slower cognitive decline (coefficients: 0.035 to 0.203, p < 0.05), except for verbal fluency.
Discussion: Higher LBM and FBM in later life may be associated with better cognition, while abdominal fat could be a risk factor.
Highligths: Higher WBR is associated with greater dementia risk, only in men.Higher WBR is associated with faster cognitive decline.Greater LBM and FBM are associated with lower dementia risk.Greater LBM and FBM are associated with slower cognitive decline.Central adiposity may be a risk factor for cognitive impairment in older adults.
期刊介绍：
Alzheimer''s & Dementia: Diagnosis, Assessment & Disease Monitoring (DADM) is an open access, peer-reviewed, journal from the Alzheimer''s Association® that will publish new research that reports the discovery, development and validation of instruments, technologies, algorithms, and innovative processes. Papers will cover a range of topics interested in the early and accurate detection of individuals with memory complaints and/or among asymptomatic individuals at elevated risk for various forms of memory disorders. The expectation for published papers will be to translate fundamental knowledge about the neurobiology of the disease into practical reports that describe both the conceptual and methodological aspects of the submitted scientific inquiry. Published topics will explore the development of biomarkers, surrogate markers, and conceptual/methodological challenges. Publication priority will be given to papers that 1) describe putative surrogate markers that accurately track disease progression, 2) biomarkers that fulfill international regulatory requirements, 3) reports from large, well-characterized population-based cohorts that comprise the heterogeneity and diversity of asymptomatic individuals and 4) algorithmic development that considers multi-marker arrays (e.g., integrated-omics, genetics, biofluids, imaging, etc.) and advanced computational analytics and technologies.
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