短期记忆容量能改变静息时的大脑行为吗?来自神经心理学评估和动态因果模型的发现。

IF 1.4 4区 心理学 Q4 CLINICAL NEUROLOGY
Ahmad Nazlim Yusoff, Elza Azri Othman, Mazlyfarina Mohamad, Hanani Abdul Manan, Aini Ismafairus Abd Hamid, Mariam Adawiah Dzulkifli
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引用次数: 0

摘要

本研究旨在探讨健康个体静息脑的短期记忆能力,特别是神经心理和连接行为。这些结果可以作为临床诊断由于衰老和精神障碍导致的记忆衰退的基线。假设低STMC个体和典型STMC个体的静息脑行为不同。从当地大学招募了39名健康的年轻男性。根据他们在马来语版本的听觉语言学习测试(MVAVLT)中的分数,他们被分为典型或低STMC。静息状态功能磁共振成像(rs-fMRI),采用统计参数映射(SPM)和动态因果模型(DCM)对数据进行分析。9项神经心理评估显著高于对照组(p < 0.05)。一个包含这些集群作为节点的因果模型发现,在典型和低STMC群体之间没有对消极或积极连接的偏好。然而,实施减少连接方案显示低STMC组的连接更显著。综上所述,低STMC参与者在所有神经心理学评估中得分都较低,但与典型STMC组相比,他们的激活谱更高,有效连接的区域更多。结果表明,低STMC个体的静息神经活动和大脑某些区域之间的交流更高,大脑可能已经执行了一种补偿策略。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Can short-term memory capacity change resting brain behavior? Findings from neuropsychological assessment and dynamic causal modeling.

This study aimed to investigate different short-term memory capacities (STMC) on resting brain of healthy individuals particularly the neuropsychology and connectivity behaviors. The outcomes may serve as a baseline for clinical diagnosis of memory decline due to aging and mental disorders. It was hypothesized that resting brain of low and typical STMC individuals behaves differently. Thirty-nine healthy young male adults were recruited from local universities. They were categorized as typical or low STMC based on their scores in the Malay Version of the Auditory-Verbal Learning Test (MVAVLT). A resting-state functional magnetic resonance imaging (rs-fMRI) was conducted and data were analyzed using statistical parametric mapping (SPM) and dynamic causal modeling (DCM). Nine neuropsychological assessments were significantly higher (p < 0.05) in typical STMC participants compared with low STMC participants. Four activation clusters survived the contrast "Low > Typical" uncorrected at set and cluster levels threshold (pFWE < 0.05). A causal model containing these clusters as nodes found that there is no preference on negative or positive connectivity among typical and low STMC groups. Nevertheless, implementing a reduced connection scheme revealed more significant connections for the low STMC group. To conclude, the low STMC participants scored lower in all neuropsychological assessments, but a higher activation profile with more areas being connected effectively as compared with the typical STMC group. The results suggest a higher resting neural activity and communication among certain brain areas in low STMC individuals that the brain could have executed as a compensation strategy.

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来源期刊
Applied Neuropsychology-Adult
Applied Neuropsychology-Adult CLINICAL NEUROLOGY-PSYCHOLOGY
CiteScore
4.50
自引率
11.80%
发文量
134
期刊介绍: pplied Neuropsychology-Adult publishes clinical neuropsychological articles concerning assessment, brain functioning and neuroimaging, neuropsychological treatment, and rehabilitation in adults. Full-length articles and brief communications are included. Case studies of adult patients carefully assessing the nature, course, or treatment of clinical neuropsychological dysfunctions in the context of scientific literature, are suitable. Review manuscripts addressing critical issues are encouraged. Preference is given to papers of clinical relevance to others in the field. All submitted manuscripts are subject to initial appraisal by the Editor-in-Chief, and, if found suitable for further considerations are peer reviewed by independent, anonymous expert referees. All peer review is single-blind and submission is online via ScholarOne Manuscripts.
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