Ahmad Nazlim Yusoff, Elza Azri Othman, Mazlyfarina Mohamad, Hanani Abdul Manan, Aini Ismafairus Abd Hamid, Mariam Adawiah Dzulkifli
{"title":"短期记忆容量能改变静息时的大脑行为吗?来自神经心理学评估和动态因果模型的发现。","authors":"Ahmad Nazlim Yusoff, Elza Azri Othman, Mazlyfarina Mohamad, Hanani Abdul Manan, Aini Ismafairus Abd Hamid, Mariam Adawiah Dzulkifli","doi":"10.1080/23279095.2025.2520473","DOIUrl":null,"url":null,"abstract":"<p><p>This study aimed to investigate different short-term memory capacities (STMC) on resting brain of healthy individuals particularly the neuropsychology and connectivity behaviors. The outcomes may serve as a baseline for clinical diagnosis of memory decline due to aging and mental disorders. It was hypothesized that resting brain of low and typical STMC individuals behaves differently. Thirty-nine healthy young male adults were recruited from local universities. They were categorized as typical or low STMC based on their scores in the Malay Version of the Auditory-Verbal Learning Test (MVAVLT). A resting-state functional magnetic resonance imaging (rs-fMRI) was conducted and data were analyzed using statistical parametric mapping (SPM) and dynamic causal modeling (DCM). Nine neuropsychological assessments were significantly higher (<i>p</i> < 0.05) in typical STMC participants compared with low STMC participants. Four activation clusters survived the contrast \"Low > Typical\" uncorrected at set and cluster levels threshold (<i>p</i><sub>FWE</sub> < 0.05). A causal model containing these clusters as nodes found that there is no preference on negative or positive connectivity among typical and low STMC groups. Nevertheless, implementing a reduced connection scheme revealed more significant connections for the low STMC group. To conclude, the low STMC participants scored lower in all neuropsychological assessments, but a higher activation profile with more areas being connected effectively as compared with the typical STMC group. The results suggest a higher resting neural activity and communication among certain brain areas in low STMC individuals that the brain could have executed as a compensation strategy.</p>","PeriodicalId":51308,"journal":{"name":"Applied Neuropsychology-Adult","volume":" ","pages":"1-15"},"PeriodicalIF":1.4000,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Can short-term memory capacity change resting brain behavior? Findings from neuropsychological assessment and dynamic causal modeling.\",\"authors\":\"Ahmad Nazlim Yusoff, Elza Azri Othman, Mazlyfarina Mohamad, Hanani Abdul Manan, Aini Ismafairus Abd Hamid, Mariam Adawiah Dzulkifli\",\"doi\":\"10.1080/23279095.2025.2520473\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>This study aimed to investigate different short-term memory capacities (STMC) on resting brain of healthy individuals particularly the neuropsychology and connectivity behaviors. The outcomes may serve as a baseline for clinical diagnosis of memory decline due to aging and mental disorders. It was hypothesized that resting brain of low and typical STMC individuals behaves differently. Thirty-nine healthy young male adults were recruited from local universities. They were categorized as typical or low STMC based on their scores in the Malay Version of the Auditory-Verbal Learning Test (MVAVLT). A resting-state functional magnetic resonance imaging (rs-fMRI) was conducted and data were analyzed using statistical parametric mapping (SPM) and dynamic causal modeling (DCM). Nine neuropsychological assessments were significantly higher (<i>p</i> < 0.05) in typical STMC participants compared with low STMC participants. Four activation clusters survived the contrast \\\"Low > Typical\\\" uncorrected at set and cluster levels threshold (<i>p</i><sub>FWE</sub> < 0.05). A causal model containing these clusters as nodes found that there is no preference on negative or positive connectivity among typical and low STMC groups. Nevertheless, implementing a reduced connection scheme revealed more significant connections for the low STMC group. To conclude, the low STMC participants scored lower in all neuropsychological assessments, but a higher activation profile with more areas being connected effectively as compared with the typical STMC group. 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Can short-term memory capacity change resting brain behavior? Findings from neuropsychological assessment and dynamic causal modeling.
This study aimed to investigate different short-term memory capacities (STMC) on resting brain of healthy individuals particularly the neuropsychology and connectivity behaviors. The outcomes may serve as a baseline for clinical diagnosis of memory decline due to aging and mental disorders. It was hypothesized that resting brain of low and typical STMC individuals behaves differently. Thirty-nine healthy young male adults were recruited from local universities. They were categorized as typical or low STMC based on their scores in the Malay Version of the Auditory-Verbal Learning Test (MVAVLT). A resting-state functional magnetic resonance imaging (rs-fMRI) was conducted and data were analyzed using statistical parametric mapping (SPM) and dynamic causal modeling (DCM). Nine neuropsychological assessments were significantly higher (p < 0.05) in typical STMC participants compared with low STMC participants. Four activation clusters survived the contrast "Low > Typical" uncorrected at set and cluster levels threshold (pFWE < 0.05). A causal model containing these clusters as nodes found that there is no preference on negative or positive connectivity among typical and low STMC groups. Nevertheless, implementing a reduced connection scheme revealed more significant connections for the low STMC group. To conclude, the low STMC participants scored lower in all neuropsychological assessments, but a higher activation profile with more areas being connected effectively as compared with the typical STMC group. The results suggest a higher resting neural activity and communication among certain brain areas in low STMC individuals that the brain could have executed as a compensation strategy.
期刊介绍:
pplied Neuropsychology-Adult publishes clinical neuropsychological articles concerning assessment, brain functioning and neuroimaging, neuropsychological treatment, and rehabilitation in adults. Full-length articles and brief communications are included. Case studies of adult patients carefully assessing the nature, course, or treatment of clinical neuropsychological dysfunctions in the context of scientific literature, are suitable. Review manuscripts addressing critical issues are encouraged. Preference is given to papers of clinical relevance to others in the field. All submitted manuscripts are subject to initial appraisal by the Editor-in-Chief, and, if found suitable for further considerations are peer reviewed by independent, anonymous expert referees. All peer review is single-blind and submission is online via ScholarOne Manuscripts.