Tyler D DeSena, LaYow C Yu, S Robert Rozbruch, Taylor J Reif, Jidapa Wongcharoenwatana, Jason S Hoellwarth
{"title":"经股骨骨整合治疗先前截肢患者感染全膝关节置换术的结果。","authors":"Tyler D DeSena, LaYow C Yu, S Robert Rozbruch, Taylor J Reif, Jidapa Wongcharoenwatana, Jason S Hoellwarth","doi":"10.1177/15563316251343034","DOIUrl":null,"url":null,"abstract":"<p><p><i>Background:</i> Management of total knee arthroplasty (TKA) periprosthetic joint infection (PJI) can prompt knee fusion or transfemoral amputation, both associated with poor mobility. The titanium transcutaneous osseointegrated nail (TiTON) provides superior mobility versus traditional socket prostheses but has been minimally studied for amputees with prior TKA PJI. <i>Purpose</i>: This study investigated the complications and mobility experience of 9 transfemoral osseointegration patients whose initial amputation was for TKA PJI management. <i>Methods</i>: A retrospective review of a prospectively maintained registry was conducted of 9 patients whose unilateral transfemoral osseointegration was performed following TKA PJI. Complications associated with the implantation of the titanium implant were noted, specifically antibiotic prescription or any additional surgery. K-level mobility performance before and after osseointegration was also compared. <i>Results</i>: Three patients (33.3%) had management for an infectious concern: 2 had a 10-day course of oral doxycycline for periportal drainage, and 1 had operative debridement with implant retention. No other complications (periprosthetic fracture, implant removal, and additional amputation) occurred. Eight patients (88.9%) improved their K-level, while 1 remained at K3. None declined. All achieved at least K2. Three patients were wheelchair-bound (K0) before osseointegration and achieved K3 or better. <i>Conclusions</i>: While infection may occur in patients who have TiTON following TKA PJI, our findings suggest that it does not seem inevitable, severe, or likely to further disable the patient. We noted meaningful mobility improvement that was common and lasting. Although our sample was small, we suggest that TiTON seems safe and reasonable to offer to patients seeking improved mobility and quality of life after amputation for TKA PJI management. Further study is warranted.</p>","PeriodicalId":35357,"journal":{"name":"Hss Journal","volume":" ","pages":"15563316251343034"},"PeriodicalIF":1.6000,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12176782/pdf/","citationCount":"0","resultStr":"{\"title\":\"Outcomes of Transfemoral Osseointegration for Patients With Prior Amputation to Manage Infected Total Knee Arthroplasty.\",\"authors\":\"Tyler D DeSena, LaYow C Yu, S Robert Rozbruch, Taylor J Reif, Jidapa Wongcharoenwatana, Jason S Hoellwarth\",\"doi\":\"10.1177/15563316251343034\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p><i>Background:</i> Management of total knee arthroplasty (TKA) periprosthetic joint infection (PJI) can prompt knee fusion or transfemoral amputation, both associated with poor mobility. The titanium transcutaneous osseointegrated nail (TiTON) provides superior mobility versus traditional socket prostheses but has been minimally studied for amputees with prior TKA PJI. <i>Purpose</i>: This study investigated the complications and mobility experience of 9 transfemoral osseointegration patients whose initial amputation was for TKA PJI management. <i>Methods</i>: A retrospective review of a prospectively maintained registry was conducted of 9 patients whose unilateral transfemoral osseointegration was performed following TKA PJI. Complications associated with the implantation of the titanium implant were noted, specifically antibiotic prescription or any additional surgery. K-level mobility performance before and after osseointegration was also compared. <i>Results</i>: Three patients (33.3%) had management for an infectious concern: 2 had a 10-day course of oral doxycycline for periportal drainage, and 1 had operative debridement with implant retention. No other complications (periprosthetic fracture, implant removal, and additional amputation) occurred. Eight patients (88.9%) improved their K-level, while 1 remained at K3. None declined. All achieved at least K2. Three patients were wheelchair-bound (K0) before osseointegration and achieved K3 or better. <i>Conclusions</i>: While infection may occur in patients who have TiTON following TKA PJI, our findings suggest that it does not seem inevitable, severe, or likely to further disable the patient. We noted meaningful mobility improvement that was common and lasting. Although our sample was small, we suggest that TiTON seems safe and reasonable to offer to patients seeking improved mobility and quality of life after amputation for TKA PJI management. Further study is warranted.</p>\",\"PeriodicalId\":35357,\"journal\":{\"name\":\"Hss Journal\",\"volume\":\" \",\"pages\":\"15563316251343034\"},\"PeriodicalIF\":1.6000,\"publicationDate\":\"2025-06-17\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12176782/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Hss Journal\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1177/15563316251343034\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"ORTHOPEDICS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Hss Journal","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1177/15563316251343034","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"ORTHOPEDICS","Score":null,"Total":0}
Outcomes of Transfemoral Osseointegration for Patients With Prior Amputation to Manage Infected Total Knee Arthroplasty.
Background: Management of total knee arthroplasty (TKA) periprosthetic joint infection (PJI) can prompt knee fusion or transfemoral amputation, both associated with poor mobility. The titanium transcutaneous osseointegrated nail (TiTON) provides superior mobility versus traditional socket prostheses but has been minimally studied for amputees with prior TKA PJI. Purpose: This study investigated the complications and mobility experience of 9 transfemoral osseointegration patients whose initial amputation was for TKA PJI management. Methods: A retrospective review of a prospectively maintained registry was conducted of 9 patients whose unilateral transfemoral osseointegration was performed following TKA PJI. Complications associated with the implantation of the titanium implant were noted, specifically antibiotic prescription or any additional surgery. K-level mobility performance before and after osseointegration was also compared. Results: Three patients (33.3%) had management for an infectious concern: 2 had a 10-day course of oral doxycycline for periportal drainage, and 1 had operative debridement with implant retention. No other complications (periprosthetic fracture, implant removal, and additional amputation) occurred. Eight patients (88.9%) improved their K-level, while 1 remained at K3. None declined. All achieved at least K2. Three patients were wheelchair-bound (K0) before osseointegration and achieved K3 or better. Conclusions: While infection may occur in patients who have TiTON following TKA PJI, our findings suggest that it does not seem inevitable, severe, or likely to further disable the patient. We noted meaningful mobility improvement that was common and lasting. Although our sample was small, we suggest that TiTON seems safe and reasonable to offer to patients seeking improved mobility and quality of life after amputation for TKA PJI management. Further study is warranted.
期刊介绍:
The HSS Journal is the Musculoskeletal Journal of Hospital for Special Surgery. The aim of the HSS Journal is to promote cutting edge research, clinical pathways, and state-of-the-art techniques that inform and facilitate the continuing education of the orthopaedic and musculoskeletal communities. HSS Journal publishes articles that offer contributions to the advancement of the knowledge of musculoskeletal diseases and encourages submission of manuscripts from all musculoskeletal disciplines.