CMKLR-1在人主动脉中的表达以平滑肌细胞阳性为主。

IF 1.9 4区 生物学 Q4 CELL BIOLOGY
Journal of Histochemistry & Cytochemistry Pub Date : 2025-05-01 Epub Date: 2025-06-24 DOI:10.1369/00221554251350743
Hannes Öster, Trina Chen, Ari Mennander, Timo Paavonen, Ivana Kholová
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引用次数: 0

摘要

趋化因子样受体1 (Chemokine-like receptor 1, CMKLR-1)是一种g蛋白偶联受体,是趋化素的结合位点。它在多种免疫细胞中诱导趋化,最近被发现与炎症中的血管重塑有关。在这项研究中,我们研究了CMKLR-1在人类主动脉样本中的表达,重点关注其在不同细胞类型中的分布及其与临床和组织形态学数据的潜在关联,特别是与主动脉夹层和动脉瘤有关。我们使用免疫组织化学CMKLR-1染色分析了62份主动脉样本,这些样本来自于接受夹层手术(n = 27)或动脉瘤/扩张(n = 35)的患者。CMKLR-1主要在主动脉中层平滑肌细胞(SMCs)中表达,未染色的中央切片呈带状染色。CMKLR-1阳性仅在少数病例中观察到介质层的内外部分。三分之一的血管血管染色。淋巴细胞、巨噬细胞和内皮细胞染色少见。CMKLR-1的表达在夹层和动脉瘤病例之间以及临床和组织形态学数据均无显著差异。虽然CMKLR-1的表达在研究的情况下没有区别,但它在主动脉介质中的存在,特别是在SMCs中,是值得注意的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
CMKLR-1 Expression in Human Aorta Is Dominated by Smooth Muscle Cell Positivity.

Chemokine-like receptor 1 (CMKLR-1) is a G-protein-coupled receptor that functions as the binding site of chemerin. It induces chemotaxis in various immune cells, and it has recently been linked to vascular remodeling in inflammation. In this study, we investigated CMKLR-1 expression in human aorta samples, focusing on its distribution across different cell types and its potential association with clinical and histomorphological data, particularly concerning aortic dissection and aneurysms. We analyzed 62 aorta samples taken from patients undergoing dissection surgery (n = 27) or aneurysm/dilatation (n = 35) using immunohistochemical CMKLR-1 staining. CMKLR-1 expression was primarily observed in the smooth muscle cells (SMCs) of the aortic media layer, and band-like coloring appeared in the unstained center section. CMKLR-1 positivity in the inner and outer parts of the media layer was observed in only a few cases. One-third of the vasa vasorum exhibited staining. Staining in lymphocytes, macrophages, and endothelia was rare. No significant differences in CMKLR-1 expression were found between the dissection and aneurysm cases, and the clinical or histomorphological data. Although CMKLR-1 expression did not distinguish between the studied conditions, its presence in the aortic media, especially in SMCs, is noteworthy.

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来源期刊
CiteScore
6.00
自引率
0.00%
发文量
32
审稿时长
1 months
期刊介绍: Journal of Histochemistry & Cytochemistry (JHC) has been a pre-eminent cell biology journal for over 50 years. Published monthly, JHC offers primary research articles, timely reviews, editorials, and perspectives on the structure and function of cells, tissues, and organs, as well as mechanisms of development, differentiation, and disease. JHC also publishes new developments in microscopy and imaging, especially where imaging techniques complement current genetic, molecular and biochemical investigations of cell and tissue function. JHC offers generous space for articles and recognizing the value of images that reveal molecular, cellular and tissue organization, offers free color to all authors.
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