抗衰老药物治疗骨科疾病的研究进展。

IF 3.1 3区 医学 Q3 GERIATRICS & GERONTOLOGY
Gerontology Pub Date : 2025-01-01 Epub Date: 2025-02-12 DOI:10.1159/000543386
Minjie Zhang, Pengqiang Lou, Dan Shou, Peijian Tong, Yang Zhang
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引用次数: 0

摘要

背景:骨科疾病,包括骨关节炎、骨质疏松症和与年龄相关的肌肉骨骼疾病,显著影响生活质量,并在老龄化人群中变得越来越普遍。越来越多的证据强调了细胞衰老在这些疾病发病机制中的作用。衰老细胞(SCs)的特征是不可逆的细胞周期停滞,随着时间的推移在组织中积累,导致炎症、组织变性和再生受损。旨在选择性消除这些SCs的新兴领域senolytics作为一种新的矫形外科治疗策略已经引起了人们的关注。摘要:抗衰老药物,包括小分子、多肽和天然化合物,在临床前模型和早期临床试验中显示出治疗各种年龄相关疾病的前景。在矫形外科中,老年性治疗因其改善软骨退化、骨脆性和其他与衰老相关的退行性变化的潜力而受到研究。最近的研究表明,在肌肉骨骼组织中靶向SCs可以改善组织功能,减少炎症,促进再生。虽然大多数研究仍处于临床前阶段,但动物研究和早期临床试验的积极结果表明,抗衰老药物可能为骨科疾病提供新的治疗途径。关键信息:抗衰老疗法通过靶向导致组织变性和炎症的潜在细胞衰老,在治疗骨科疾病方面具有巨大的潜力。临床前和临床研究表明,抗衰老药物可以增强肌肉骨骼疾病的组织修复,减轻症状,减缓疾病进展。需要进一步的研究来优化药物疗效,确保安全性,并确定可能从这些治疗中获益最多的患者群体。抗衰老药物的开发可以彻底改变与衰老相关的骨科疾病的管理,提供比目前治疗更有针对性和更有效的方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Research Progress of Senolytic Drugs in the Treatment of Orthopedic Diseases.

Background: Orthopedic diseases, including osteoarthritis, osteoporosis, and age-related musculoskeletal disorders, significantly impact quality of life and are becoming increasingly prevalent with aging populations. A growing body of evidence highlights the role of cellular senescence in the pathogenesis of these conditions. Senescent cells (SCs), characterized by irreversible cell cycle arrest, accumulate in tissues over time, contributing to inflammation, tissue degeneration, and impaired regeneration. The emerging field of senolytics, which aims to selectively eliminate these SCs, has garnered attention as a novel therapeutic strategy in orthopedics.

Summary: Senolytic drugs, including small molecules, peptides, and natural compounds, have shown promise in preclinical models and early clinical trials for the treatment of various age-related diseases. In orthopedics, senolytics have been investigated for their potential to ameliorate cartilage degradation, bone fragility, and other degenerative changes associated with aging. Recent studies have demonstrated that targeting SCs in musculoskeletal tissues can improve tissue function, reduce inflammation, and promote regeneration. Although the majority of research is still in the preclinical phase, the positive outcomes from animal studies and early clinical trials suggest that senolytic drugs may offer new therapeutic avenues for orthopedic diseases.

Key messages: Senolytic therapies hold significant potential for treating orthopedic diseases by targeting the underlying cellular senescence that contributes to tissue degeneration and inflammation. Preclinical and clinical studies indicate that senolytic drugs may enhance tissue repair, alleviate symptoms, and slow disease progression in musculoskeletal disorders. Further research is needed to optimize drug efficacy, ensure safety, and identify patient populations that may benefit the most from these treatments. The development of senolytic drugs could revolutionize the management of aging-related orthopedic diseases, providing a more targeted and effective approach than current treatments.

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来源期刊
Gerontology
Gerontology 医学-老年医学
CiteScore
6.00
自引率
0.00%
发文量
94
审稿时长
6-12 weeks
期刊介绍: In view of the ever-increasing fraction of elderly people, understanding the mechanisms of aging and age-related diseases has become a matter of urgent necessity. ''Gerontology'', the oldest journal in the field, responds to this need by drawing topical contributions from multiple disciplines to support the fundamental goals of extending active life and enhancing its quality. The range of papers is classified into four sections. In the Clinical Section, the aetiology, pathogenesis, prevention and treatment of agerelated diseases are discussed from a gerontological rather than a geriatric viewpoint. The Experimental Section contains up-to-date contributions from basic gerontological research. Papers dealing with behavioural development and related topics are placed in the Behavioural Science Section. Basic aspects of regeneration in different experimental biological systems as well as in the context of medical applications are dealt with in a special section that also contains information on technological advances for the elderly. Providing a primary source of high-quality papers covering all aspects of aging in humans and animals, ''Gerontology'' serves as an ideal information tool for all readers interested in the topic of aging from a broad perspective.
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