Minjie Zhang, Pengqiang Lou, Dan Shou, Peijian Tong, Yang Zhang
{"title":"抗衰老药物治疗骨科疾病的研究进展。","authors":"Minjie Zhang, Pengqiang Lou, Dan Shou, Peijian Tong, Yang Zhang","doi":"10.1159/000543386","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Orthopedic diseases, including osteoarthritis, osteoporosis, and age-related musculoskeletal disorders, significantly impact quality of life and are becoming increasingly prevalent with aging populations. A growing body of evidence highlights the role of cellular senescence in the pathogenesis of these conditions. Senescent cells (SCs), characterized by irreversible cell cycle arrest, accumulate in tissues over time, contributing to inflammation, tissue degeneration, and impaired regeneration. The emerging field of senolytics, which aims to selectively eliminate these SCs, has garnered attention as a novel therapeutic strategy in orthopedics.</p><p><strong>Summary: </strong>Senolytic drugs, including small molecules, peptides, and natural compounds, have shown promise in preclinical models and early clinical trials for the treatment of various age-related diseases. In orthopedics, senolytics have been investigated for their potential to ameliorate cartilage degradation, bone fragility, and other degenerative changes associated with aging. Recent studies have demonstrated that targeting SCs in musculoskeletal tissues can improve tissue function, reduce inflammation, and promote regeneration. Although the majority of research is still in the preclinical phase, the positive outcomes from animal studies and early clinical trials suggest that senolytic drugs may offer new therapeutic avenues for orthopedic diseases.</p><p><strong>Key messages: </strong>Senolytic therapies hold significant potential for treating orthopedic diseases by targeting the underlying cellular senescence that contributes to tissue degeneration and inflammation. Preclinical and clinical studies indicate that senolytic drugs may enhance tissue repair, alleviate symptoms, and slow disease progression in musculoskeletal disorders. Further research is needed to optimize drug efficacy, ensure safety, and identify patient populations that may benefit the most from these treatments. The development of senolytic drugs could revolutionize the management of aging-related orthopedic diseases, providing a more targeted and effective approach than current treatments.</p>","PeriodicalId":12662,"journal":{"name":"Gerontology","volume":"71 3","pages":"221-238"},"PeriodicalIF":3.1000,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Research Progress of Senolytic Drugs in the Treatment of Orthopedic Diseases.\",\"authors\":\"Minjie Zhang, Pengqiang Lou, Dan Shou, Peijian Tong, Yang Zhang\",\"doi\":\"10.1159/000543386\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Orthopedic diseases, including osteoarthritis, osteoporosis, and age-related musculoskeletal disorders, significantly impact quality of life and are becoming increasingly prevalent with aging populations. A growing body of evidence highlights the role of cellular senescence in the pathogenesis of these conditions. Senescent cells (SCs), characterized by irreversible cell cycle arrest, accumulate in tissues over time, contributing to inflammation, tissue degeneration, and impaired regeneration. The emerging field of senolytics, which aims to selectively eliminate these SCs, has garnered attention as a novel therapeutic strategy in orthopedics.</p><p><strong>Summary: </strong>Senolytic drugs, including small molecules, peptides, and natural compounds, have shown promise in preclinical models and early clinical trials for the treatment of various age-related diseases. In orthopedics, senolytics have been investigated for their potential to ameliorate cartilage degradation, bone fragility, and other degenerative changes associated with aging. Recent studies have demonstrated that targeting SCs in musculoskeletal tissues can improve tissue function, reduce inflammation, and promote regeneration. Although the majority of research is still in the preclinical phase, the positive outcomes from animal studies and early clinical trials suggest that senolytic drugs may offer new therapeutic avenues for orthopedic diseases.</p><p><strong>Key messages: </strong>Senolytic therapies hold significant potential for treating orthopedic diseases by targeting the underlying cellular senescence that contributes to tissue degeneration and inflammation. Preclinical and clinical studies indicate that senolytic drugs may enhance tissue repair, alleviate symptoms, and slow disease progression in musculoskeletal disorders. Further research is needed to optimize drug efficacy, ensure safety, and identify patient populations that may benefit the most from these treatments. The development of senolytic drugs could revolutionize the management of aging-related orthopedic diseases, providing a more targeted and effective approach than current treatments.</p>\",\"PeriodicalId\":12662,\"journal\":{\"name\":\"Gerontology\",\"volume\":\"71 3\",\"pages\":\"221-238\"},\"PeriodicalIF\":3.1000,\"publicationDate\":\"2025-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Gerontology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1159/000543386\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/2/12 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q3\",\"JCRName\":\"GERIATRICS & GERONTOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Gerontology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1159/000543386","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/2/12 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"GERIATRICS & GERONTOLOGY","Score":null,"Total":0}
Research Progress of Senolytic Drugs in the Treatment of Orthopedic Diseases.
Background: Orthopedic diseases, including osteoarthritis, osteoporosis, and age-related musculoskeletal disorders, significantly impact quality of life and are becoming increasingly prevalent with aging populations. A growing body of evidence highlights the role of cellular senescence in the pathogenesis of these conditions. Senescent cells (SCs), characterized by irreversible cell cycle arrest, accumulate in tissues over time, contributing to inflammation, tissue degeneration, and impaired regeneration. The emerging field of senolytics, which aims to selectively eliminate these SCs, has garnered attention as a novel therapeutic strategy in orthopedics.
Summary: Senolytic drugs, including small molecules, peptides, and natural compounds, have shown promise in preclinical models and early clinical trials for the treatment of various age-related diseases. In orthopedics, senolytics have been investigated for their potential to ameliorate cartilage degradation, bone fragility, and other degenerative changes associated with aging. Recent studies have demonstrated that targeting SCs in musculoskeletal tissues can improve tissue function, reduce inflammation, and promote regeneration. Although the majority of research is still in the preclinical phase, the positive outcomes from animal studies and early clinical trials suggest that senolytic drugs may offer new therapeutic avenues for orthopedic diseases.
Key messages: Senolytic therapies hold significant potential for treating orthopedic diseases by targeting the underlying cellular senescence that contributes to tissue degeneration and inflammation. Preclinical and clinical studies indicate that senolytic drugs may enhance tissue repair, alleviate symptoms, and slow disease progression in musculoskeletal disorders. Further research is needed to optimize drug efficacy, ensure safety, and identify patient populations that may benefit the most from these treatments. The development of senolytic drugs could revolutionize the management of aging-related orthopedic diseases, providing a more targeted and effective approach than current treatments.
期刊介绍:
In view of the ever-increasing fraction of elderly people, understanding the mechanisms of aging and age-related diseases has become a matter of urgent necessity. ''Gerontology'', the oldest journal in the field, responds to this need by drawing topical contributions from multiple disciplines to support the fundamental goals of extending active life and enhancing its quality. The range of papers is classified into four sections. In the Clinical Section, the aetiology, pathogenesis, prevention and treatment of agerelated diseases are discussed from a gerontological rather than a geriatric viewpoint. The Experimental Section contains up-to-date contributions from basic gerontological research. Papers dealing with behavioural development and related topics are placed in the Behavioural Science Section. Basic aspects of regeneration in different experimental biological systems as well as in the context of medical applications are dealt with in a special section that also contains information on technological advances for the elderly. Providing a primary source of high-quality papers covering all aspects of aging in humans and animals, ''Gerontology'' serves as an ideal information tool for all readers interested in the topic of aging from a broad perspective.