SERCA阻断作为肥胖的治疗策略。

IF 2.7 3区医学 Q2 PHYSIOLOGY

European Journal of Applied Physiology Pub Date : 2025-09-01 Epub Date: 2025-06-23 DOI:10.1007/s00421-025-05852-9

Suha Al-Naimi, Rizwan Qaisar

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引用次数: 0

摘要

Sarco/内质网钙atp酶（SERCA）泵对于维持包括脂肪细胞在内的各种细胞类型的钙稳态至关重要。SERCA功能与代谢健康密切相关，因为SERCA的失调与肥胖的发生有关。因此，调节SERCA可能与治疗肥胖及相关并发症具有临床相关性。我们讨论了各种药理学和遗传学工具来调节SERCA功能治疗肥胖。接下来，我们将讨论调节SERCA对肥胖的治疗效果的临床前和临床数据。我们还讨论了sarcolipin，一种与SERCA相关的抑制蛋白，作为调节SERCA的分子靶点。最后，我们讨论了调节SERCA治疗肥胖的挑战、临床意义和未来方向。

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SERCA blockade as a treatment strategy for obesity.

Sarco/endoplasmic reticulum calcium ATPase (SERCA) pump is essential for maintaining calcium homeostasis in various cell types, including adipocytes. The SERCA function is closely associated with metabolic health, as the dysregulation of SERCA is implicated in the development of obesity. Thus, regulating SERCA may be clinically relevant for treating obesity and related complications. We discuss various pharmacological and genetic tools to regulate SERCA function for treating obesity. Next, we discuss preclinical and clinical data on the therapeutic efficacy of regulating SERCA in obesity. We also discuss sarcolipin, a SERCA-associated inhibitory protein, as a molecular target for regulating SERCA. Lastly, we discuss challenges, clinical implications, and future directions of regulating SERCA for treating obesity.

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来源期刊

European Journal of Applied Physiology 医学-生理学

CiteScore

6.00

自引率

6.70%

发文量

227

审稿时长

3 months

期刊介绍： The European Journal of Applied Physiology (EJAP) aims to promote mechanistic advances in human integrative and translational physiology. Physiology is viewed broadly, having overlapping context with related disciplines such as biomechanics, biochemistry, endocrinology, ergonomics, immunology, motor control, and nutrition. EJAP welcomes studies dealing with physical exercise, training and performance. Studies addressing physiological mechanisms are preferred over descriptive studies. Papers dealing with animal models or pathophysiological conditions are not excluded from consideration, but must be clearly relevant to human physiology.