{"title":"骨软骨类器官生物制造：构建策略、应用与展望。","authors":"Liwei Fu, Jiang Wu, Zhichao Zhang, Zhixing Zhang, Yazhe Zheng, Li Pinxue, Chuanyang Long, Xiang Sui, Shuyun Liu, Quanyi Guo","doi":"10.1088/1758-5090/ade740","DOIUrl":null,"url":null,"abstract":"<p><p>Osteochondral tissue is a functional complex with crosstalk shown to occur between cartilage and subchondral bone, playing a pivotal role in joint function and mobility. Osteochondral tissue repair has long been an enormous challenge in regenerative medicine and tissue engineering. With the development of biofabrication and biomaterials innovations, organoid technology, which can mimic the biological architecture and characteristics of organs through the construction of 3D tissue structures<i>in vitro</i>, provides novel insight into osteochondral (OC) tissue regeneration. This review explores the significance of OC organoid biofabrication and the related biological structures and functions of the joint OC unit. Furthermore, we summarize novel biofabrication technologies used for OC organoids, such as 3D printing and microfluidics, and propose construction strategies for OC organoids. Finally, the application directions and challenges of OC organoids are outlined, emphasizing their potential for OC disease treatment.</p>","PeriodicalId":8964,"journal":{"name":"Biofabrication","volume":" ","pages":""},"PeriodicalIF":8.2000,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Osteochondral organoid biofabrication: construction strategies, applications and perspectives.\",\"authors\":\"Liwei Fu, Jiang Wu, Zhichao Zhang, Zhixing Zhang, Yazhe Zheng, Li Pinxue, Chuanyang Long, Xiang Sui, Shuyun Liu, Quanyi Guo\",\"doi\":\"10.1088/1758-5090/ade740\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Osteochondral tissue is a functional complex with crosstalk shown to occur between cartilage and subchondral bone, playing a pivotal role in joint function and mobility. Osteochondral tissue repair has long been an enormous challenge in regenerative medicine and tissue engineering. With the development of biofabrication and biomaterials innovations, organoid technology, which can mimic the biological architecture and characteristics of organs through the construction of 3D tissue structures<i>in vitro</i>, provides novel insight into osteochondral (OC) tissue regeneration. This review explores the significance of OC organoid biofabrication and the related biological structures and functions of the joint OC unit. Furthermore, we summarize novel biofabrication technologies used for OC organoids, such as 3D printing and microfluidics, and propose construction strategies for OC organoids. Finally, the application directions and challenges of OC organoids are outlined, emphasizing their potential for OC disease treatment.</p>\",\"PeriodicalId\":8964,\"journal\":{\"name\":\"Biofabrication\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":8.2000,\"publicationDate\":\"2025-07-17\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Biofabrication\",\"FirstCategoryId\":\"5\",\"ListUrlMain\":\"https://doi.org/10.1088/1758-5090/ade740\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"ENGINEERING, BIOMEDICAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biofabrication","FirstCategoryId":"5","ListUrlMain":"https://doi.org/10.1088/1758-5090/ade740","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENGINEERING, BIOMEDICAL","Score":null,"Total":0}
Osteochondral organoid biofabrication: construction strategies, applications and perspectives.
Osteochondral tissue is a functional complex with crosstalk shown to occur between cartilage and subchondral bone, playing a pivotal role in joint function and mobility. Osteochondral tissue repair has long been an enormous challenge in regenerative medicine and tissue engineering. With the development of biofabrication and biomaterials innovations, organoid technology, which can mimic the biological architecture and characteristics of organs through the construction of 3D tissue structuresin vitro, provides novel insight into osteochondral (OC) tissue regeneration. This review explores the significance of OC organoid biofabrication and the related biological structures and functions of the joint OC unit. Furthermore, we summarize novel biofabrication technologies used for OC organoids, such as 3D printing and microfluidics, and propose construction strategies for OC organoids. Finally, the application directions and challenges of OC organoids are outlined, emphasizing their potential for OC disease treatment.
期刊介绍：
Biofabrication is dedicated to advancing cutting-edge research on the utilization of cells, proteins, biological materials, and biomaterials as fundamental components for the construction of biological systems and/or therapeutic products. Additionally, it proudly serves as the official journal of the International Society for Biofabrication (ISBF).
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