{"title":"3D打印在骨软骨再生中的临床应用进展。","authors":"Gozde Enguven, Aysegul Tiryaki, Ayse Ceren Calikoglu Koyuncu, Oguzhan Gunduz","doi":"10.1007/5584_2025_864","DOIUrl":null,"url":null,"abstract":"<p><p>Osteochondral (OC) diseases, which usually occur as a result of the sedentary life brought by today's conditions, lead to a painful and uncomfortable life, especially in later ages. Although there are many non-invasive and invasive methods for the elimination of osteochondral damage, none of them provide full recovery. For this reason, approaches that include advanced tissue engineering techniques are being put forward for the permanent treatment of damage by mimicking the natural tissue architecture. This chapter highlights preclinical and clinical advancements in OC tissue regeneration mainly focused on 3D printing. First, the cellular structure and composition of OC tissue are explained. Next, current strategies for the fabrication of 3D-printed scaffold OC tissue are discussed. Finally, the clinical applications of 3D-printed scaffolds are presented.</p>","PeriodicalId":7270,"journal":{"name":"Advances in experimental medicine and biology","volume":" ","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Advances in Clinical Implications of 3D Printing for Osteochondral Regeneration.\",\"authors\":\"Gozde Enguven, Aysegul Tiryaki, Ayse Ceren Calikoglu Koyuncu, Oguzhan Gunduz\",\"doi\":\"10.1007/5584_2025_864\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Osteochondral (OC) diseases, which usually occur as a result of the sedentary life brought by today's conditions, lead to a painful and uncomfortable life, especially in later ages. Although there are many non-invasive and invasive methods for the elimination of osteochondral damage, none of them provide full recovery. For this reason, approaches that include advanced tissue engineering techniques are being put forward for the permanent treatment of damage by mimicking the natural tissue architecture. This chapter highlights preclinical and clinical advancements in OC tissue regeneration mainly focused on 3D printing. First, the cellular structure and composition of OC tissue are explained. Next, current strategies for the fabrication of 3D-printed scaffold OC tissue are discussed. Finally, the clinical applications of 3D-printed scaffolds are presented.</p>\",\"PeriodicalId\":7270,\"journal\":{\"name\":\"Advances in experimental medicine and biology\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2025-06-25\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Advances in experimental medicine and biology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1007/5584_2025_864\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"Biochemistry, Genetics and Molecular Biology\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Advances in experimental medicine and biology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/5584_2025_864","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"Biochemistry, Genetics and Molecular Biology","Score":null,"Total":0}
Advances in Clinical Implications of 3D Printing for Osteochondral Regeneration.
Osteochondral (OC) diseases, which usually occur as a result of the sedentary life brought by today's conditions, lead to a painful and uncomfortable life, especially in later ages. Although there are many non-invasive and invasive methods for the elimination of osteochondral damage, none of them provide full recovery. For this reason, approaches that include advanced tissue engineering techniques are being put forward for the permanent treatment of damage by mimicking the natural tissue architecture. This chapter highlights preclinical and clinical advancements in OC tissue regeneration mainly focused on 3D printing. First, the cellular structure and composition of OC tissue are explained. Next, current strategies for the fabrication of 3D-printed scaffold OC tissue are discussed. Finally, the clinical applications of 3D-printed scaffolds are presented.
期刊介绍：
Advances in Experimental Medicine and Biology provides a platform for scientific contributions in the main disciplines of the biomedicine and the life sciences. This series publishes thematic volumes on contemporary research in the areas of microbiology, immunology, neurosciences, biochemistry, biomedical engineering, genetics, physiology, and cancer research. Covering emerging topics and techniques in basic and clinical science, it brings together clinicians and researchers from various fields.
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