可吸收生物材料的开发与优化及组织工程应用的先进3D支架制造技术。

IF 3.5 3区 化学 Q2 CHEMISTRY, MULTIDISCIPLINARY
Mohamed Jalaludeen Abdulkadhar, Santhoshkumar Jayakodi, Revathi Purushothaman, Beer Mohamed Syed Ali, Saranya Vinayagam, Lalitha Gnanasekaran, Praveen Ramakrishnan, Thanigaivel Sundaram
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引用次数: 0

摘要

在可吸收生物材料和作为组织再生关键框架的3D支架的创新推动下,组织工程取得了显著进展。这篇综述强调了天然和合成聚合物在支架设计中的整合,强调了它们模拟细胞外基质(ECM)和支持细胞粘附、增殖和分化的能力。先进的制造技术,如3D打印、纳米技术和静电纺丝的结合,增强了支架的功能和精度,能够创建特定患者的结构。重大挑战包括平衡支架降解率与机械强度,管理免疫反应,优化临床翻译的生物制造方法。新兴材料,包括生物活性聚合物、纳米凝胶和石墨烯基支架,以及生物制造技术的进步,如4D打印,显示出解决这些限制的巨大潜力。这篇综述强调了跨学科合作、监管适应和持续研究将支架技术从实验模型转化为实际应用的重要性。这一进展对于改善再生医学的临床结果和解决复杂的组织工程挑战至关重要。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Development and Optimization of Resorbable Biomaterials and Advanced 3D Scaffold Fabrication Techniques for Tissue Engineering Application.

Tissue engineering has advanced significantly, driven by innovations in resorbable biomaterials and 3D scaffolds that serve as critical frameworks for tissue regeneration. This review highlights the integration of natural and synthetic polymers into scaffold design, emphasizing their capacity to mimic the extracellular matrix (ECM) and support cell adhesion, proliferation, and differentiation. The incorporation of advanced fabrication techniques such as 3D printing, nanotechnology, and electrospinning has enhanced scaffold functionality and precision, enabling the creation of patient-specific constructs. Significant challenges include balancing scaffold degradation rates with mechanical strength, managing immune responses, and optimizing biofabrication methods for clinical translation. Emerging materials, including bioactive polymers, nanogels, and graphene-based scaffolds, along with advancements in biofabrication such as 4D printing, demonstrate significant potential for addressing these limitations. This review emphasizes the importance of interdisciplinary collaboration, regulatory adaptation, and continuous research to transform scaffold technologies from experimental models into practical applications. This progress is crucial for improving clinical outcomes in regenerative medicine and for addressing complex tissue engineering challenges.

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来源期刊
Chemistry - An Asian Journal
Chemistry - An Asian Journal 化学-化学综合
CiteScore
7.00
自引率
2.40%
发文量
535
审稿时长
1.3 months
期刊介绍: Chemistry—An Asian Journal is an international high-impact journal for chemistry in its broadest sense. The journal covers all aspects of chemistry from biochemistry through organic and inorganic chemistry to physical chemistry, including interdisciplinary topics. Chemistry—An Asian Journal publishes Full Papers, Communications, and Focus Reviews. A professional editorial team headed by Dr. Theresa Kueckmann and an Editorial Board (headed by Professor Susumu Kitagawa) ensure the highest quality of the peer-review process, the contents and the production of the journal. Chemistry—An Asian Journal is published on behalf of the Asian Chemical Editorial Society (ACES), an association of numerous Asian chemical societies, and supported by the Gesellschaft Deutscher Chemiker (GDCh, German Chemical Society), ChemPubSoc Europe, and the Federation of Asian Chemical Societies (FACS).
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