多囊卵巢综合征和经前紊乱的风险：瑞典一项基于全国登记的研究

IF 3.3 2区医学 Q1 PSYCHIATRY

Depression and Anxiety Pub Date : 2025-06-25 DOI:10.1155/da/8226088

Marion Opatowski, Jenny Deng, Qian Yang, Anna Sara Oberg, Carolyn E. Cesta, Donghao Lu

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引用次数: 0

摘要

背景：多囊卵巢综合征（PCOS）是影响育龄妇女最常见的内分泌疾病之一。它与一系列精神疾病有关。虽然经前障碍（ppmds）的特征是精神症状与内分泌系统控制的激素变化相关联，但PCOS与经前障碍之间的关系尚不清楚。方法：我们在2001-2018年期间在瑞典进行了一项全国性的基于登记的队列研究，包括2965178名女性。从瑞典国家登记处记录的临床诊断中确定PCOS患者（n = 41,515），根据临床诊断和随访期间具有明确PMDs指征的处方确定PCOS患者。采用多变量Cox回归，通过PCOS患者与非PCOS患者的比较，估计PCOS患者的风险比（hr）。为了考虑遗传或家庭环境等混杂因素，我们进行了兄弟姐妹比较（N = 160566）。结果：在15.3年的中位随访期间，1308例（1.9%）PCOS患者出现经前紊乱（PMD）（4.67/1000人年）。与没有多囊卵巢综合征的个体相比，他们患经前综合症的风险增加了一倍多（年龄调整HR: 2.26, 95% CI 2.14 - 2.39）。在调整了人口统计学和社会经济因素以及共病精神疾病和肥胖因素后，这种关联减弱，但仍然显著（HR: 1.54, 95% CI 1.46-1.63）。兄弟姐妹比较显示类似的结果（全校正风险比：1.61,95% CI 1.36-1.92）。无论是否存在精神合并症，多囊卵巢综合征和经前综合症之间的相关性仍然具有统计学意义，有精神合并症的人的风险比为1.33 (95% CI 1.20-1.47)，无精神合并症的人的风险比为1.55 （95% CI 1.45-1.65）。结论：我们的研究结果表明，被诊断为PCOS的个体患pmd的风险增加。这种关联不能完全用共同的风险因素来解释，包括姐妹共有的风险因素。

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Polycystic Ovary Syndrome and the Risk of Premenstrual Disorders: A Nationwide Register-Based Study in Sweden

Background: Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders affecting women of reproductive age. It has been linked to a range of psychiatric disorders. Although premenstrual disorders (PMDs) are characterized by psychiatric symptoms in tandem with hormone changes controlled by the endocrine system, the association between PCOS and PMDs remains unknown.

Methods: We conducted a nationwide register-based cohort study including 2,965,178 females during 2001–2018 in Sweden. Individuals with PCOS were identified from clinical diagnoses recorded in the Swedish national registers (n = 41,515) and PMDs were identified based on clinical diagnoses and prescriptions with a clear indication of PMDs during follow-up. Using multivariable Cox regression, hazard ratio (HRs) of PMDs were estimated by comparing individuals with PCOS to those without. To account for confounders such as genetics or family environment, we conducted sibling comparison (N = 160,566).

Results: During a median follow-up of 15.3 years, 1308 (1.9%) individuals with PCOS had a premenstrual disorder (PMD) (4.67/1000 person-years). Compared to individuals without PCOS they had more than doubled risk of PMDs (age-adjusted HR: 2.26, 95% CI 2.14– 2.39). The association was attenuated after adjustment for demographic and socioeconomic factors as well as for comorbid psychiatric disorders and obesity yet remained significant (HR: 1.54, 95% CI 1.46–1.63). The sibling comparison showed similar findings (full-adjusted HR: 1.61, 95% CI 1.36–1.92). The association between PCOS and PMDs remained statistically significant regardless of the presence of psychiatric comorbidities, with HR of 1.33 (95% CI 1.20–1.47) for individuals with psychiatric comorbidities and 1.55 (95% CI 1.45–1.65) for those without.

Conclusions: Our findings suggest that individuals diagnosed with PCOS were at increased risk for PMDs. This association could not be entirely explained by shared risk factors, including such that sisters share.

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来源期刊

Depression and Anxiety 医学-精神病学

CiteScore

15.00

自引率

1.40%

发文量

审稿时长

4-8 weeks

期刊介绍： Depression and Anxiety is a scientific journal that focuses on the study of mood and anxiety disorders, as well as related phenomena in humans. The journal is dedicated to publishing high-quality research and review articles that contribute to the understanding and treatment of these conditions. The journal places a particular emphasis on articles that contribute to the clinical evaluation and care of individuals affected by mood and anxiety disorders. It prioritizes the publication of treatment-related research and review papers, as well as those that present novel findings that can directly impact clinical practice. The journal's goal is to advance the field by disseminating knowledge that can lead to better diagnosis, treatment, and management of these disorders, ultimately improving the quality of life for those who suffer from them.