Ali Asadzadeh, Alireza Zangooie, Parmida Bagheri, Helia Zangooie, Zahra Salehi
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Pseudogenes have historically been regarded as non-functional genomic vestiges but have gained recognition for their contributory roles in the oncogenesis of CRC.</p>\n </section>\n \n <section>\n \n <h3> Aims</h3>\n \n <p>This systematic review aims to comprehensively evaluate the current literature regarding the involvement of pseudogenes in CRC, with a focus on their clinical relevance as diagnostic and prognostic biomarkers and their potential as innovative therapeutic targets.</p>\n </section>\n \n <section>\n \n <h3> Methods and Results</h3>\n \n <p>We conducted a comprehensive literature search following the PRISMA guidelines across PubMed, SCOPUS, and Web of Science databases. Two reviewers independently carried out the screening of studies and extraction of relevant data. Nineteen studies met the inclusion criteria. These studies highlight pseudogenes' emerging role in colorectal cancer, transitioning from being seen as evolutionary remnants to recognized contributors in tumorigenesis. Key pseudogenes like DUXAP8, SUCLG2P2, and SUMO1P3 are linked to crucial CRC processes such as proliferation, migration, invasion, and angiogenesis. The diagnostic and prognostic potential is found in pseudogenes like MYLKP1 (with SNPs rs12490683 and rs12497343) and POU5F1P1 (SNP rs6983267). Additionally, CDCP1, SUCLG2P2, and MT1DP offer prognostic insights, guiding personalized treatment approaches. Pseudogenes such as CTNNAP1, NMRAL2P, and DUXAP8 show therapeutic potential, advocating for further research into their mechanisms to enhance CRC diagnostics and personalized care. The intricate involvement of pseudogenes in CRC pathogenesis underscores their importance.</p>\n </section>\n \n <section>\n \n <h3> Conclusion</h3>\n \n <p>Our review illuminates the promise of pseudogenes as biomarkers and therapeutic targets, indicating a significant step toward the integration of pseudogenes in the future paradigm of precision medicine for CRC.</p>\n </section>\n </div>","PeriodicalId":9440,"journal":{"name":"Cancer reports","volume":"8 6","pages":""},"PeriodicalIF":1.5000,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cnr2.70263","citationCount":"0","resultStr":"{\"title\":\"Pseudogenes as Potential Diagnostic, Prognostic and Therapeutic Biomarkers in Colorectal Cancer: A Systematic Review\",\"authors\":\"Ali Asadzadeh, Alireza Zangooie, Parmida Bagheri, Helia Zangooie, Zahra Salehi\",\"doi\":\"10.1002/cnr2.70263\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n \\n <section>\\n \\n <h3> Background</h3>\\n \\n <p>Colorectal cancer (CRC) is a leading cause of oncologic death worldwide. Elucidating the molecular mechanisms that underpin its pathogenesis is essential for identifying novel therapeutic targets. Pseudogenes have historically been regarded as non-functional genomic vestiges but have gained recognition for their contributory roles in the oncogenesis of CRC.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Aims</h3>\\n \\n <p>This systematic review aims to comprehensively evaluate the current literature regarding the involvement of pseudogenes in CRC, with a focus on their clinical relevance as diagnostic and prognostic biomarkers and their potential as innovative therapeutic targets.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Methods and Results</h3>\\n \\n <p>We conducted a comprehensive literature search following the PRISMA guidelines across PubMed, SCOPUS, and Web of Science databases. Two reviewers independently carried out the screening of studies and extraction of relevant data. Nineteen studies met the inclusion criteria. These studies highlight pseudogenes' emerging role in colorectal cancer, transitioning from being seen as evolutionary remnants to recognized contributors in tumorigenesis. Key pseudogenes like DUXAP8, SUCLG2P2, and SUMO1P3 are linked to crucial CRC processes such as proliferation, migration, invasion, and angiogenesis. The diagnostic and prognostic potential is found in pseudogenes like MYLKP1 (with SNPs rs12490683 and rs12497343) and POU5F1P1 (SNP rs6983267). Additionally, CDCP1, SUCLG2P2, and MT1DP offer prognostic insights, guiding personalized treatment approaches. Pseudogenes such as CTNNAP1, NMRAL2P, and DUXAP8 show therapeutic potential, advocating for further research into their mechanisms to enhance CRC diagnostics and personalized care. 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引用次数: 0
摘要
结直肠癌（CRC）是世界范围内肿瘤死亡的主要原因。阐明支持其发病机制的分子机制对于确定新的治疗靶点至关重要。假基因历来被认为是无功能的基因组痕迹，但在结直肠癌的肿瘤发生中发挥了重要作用。本系统综述旨在全面评估目前关于假基因参与CRC的文献，重点关注其作为诊断和预后生物标志物的临床相关性以及作为创新治疗靶点的潜力。方法和结果我们按照PRISMA指南在PubMed、SCOPUS和Web of Science数据库中进行了全面的文献检索。两名审稿人独立进行研究筛选和相关数据提取。19项研究符合纳入标准。这些研究强调了假基因在结直肠癌中的新兴作用，从被视为进化残留物转变为肿瘤发生的公认贡献者。关键假基因如DUXAP8、SUCLG2P2和SUMO1P3与CRC的增殖、迁移、侵袭和血管生成等关键过程有关。在假基因如MYLKP1 （SNP为rs12490683和rs12497343）和POU5F1P1 （SNP为rs6983267）中发现了诊断和预后潜力。此外，CDCP1、SUCLG2P2和MT1DP提供预后见解，指导个性化治疗方法。假基因如CTNNAP1、NMRAL2P和DUXAP8显示出治疗潜力，提倡进一步研究其机制以增强CRC诊断和个性化护理。假基因在结直肠癌发病机制中的复杂参与强调了它们的重要性。结论我们的综述阐明了假基因作为生物标志物和治疗靶点的前景，表明在未来的CRC精准医学范式中整合假基因迈出了重要的一步。
Pseudogenes as Potential Diagnostic, Prognostic and Therapeutic Biomarkers in Colorectal Cancer: A Systematic Review
Background
Colorectal cancer (CRC) is a leading cause of oncologic death worldwide. Elucidating the molecular mechanisms that underpin its pathogenesis is essential for identifying novel therapeutic targets. Pseudogenes have historically been regarded as non-functional genomic vestiges but have gained recognition for their contributory roles in the oncogenesis of CRC.
Aims
This systematic review aims to comprehensively evaluate the current literature regarding the involvement of pseudogenes in CRC, with a focus on their clinical relevance as diagnostic and prognostic biomarkers and their potential as innovative therapeutic targets.
Methods and Results
We conducted a comprehensive literature search following the PRISMA guidelines across PubMed, SCOPUS, and Web of Science databases. Two reviewers independently carried out the screening of studies and extraction of relevant data. Nineteen studies met the inclusion criteria. These studies highlight pseudogenes' emerging role in colorectal cancer, transitioning from being seen as evolutionary remnants to recognized contributors in tumorigenesis. Key pseudogenes like DUXAP8, SUCLG2P2, and SUMO1P3 are linked to crucial CRC processes such as proliferation, migration, invasion, and angiogenesis. The diagnostic and prognostic potential is found in pseudogenes like MYLKP1 (with SNPs rs12490683 and rs12497343) and POU5F1P1 (SNP rs6983267). Additionally, CDCP1, SUCLG2P2, and MT1DP offer prognostic insights, guiding personalized treatment approaches. Pseudogenes such as CTNNAP1, NMRAL2P, and DUXAP8 show therapeutic potential, advocating for further research into their mechanisms to enhance CRC diagnostics and personalized care. The intricate involvement of pseudogenes in CRC pathogenesis underscores their importance.
Conclusion
Our review illuminates the promise of pseudogenes as biomarkers and therapeutic targets, indicating a significant step toward the integration of pseudogenes in the future paradigm of precision medicine for CRC.
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