Ya Chen, Xia Zhang, Chengyu Pan, Zhongxiang Xu, Zucai Xu
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We employed linear regression to assess the independent risk factors for the number of EPVS, and Cox regression was used to elucidate the independent factors associated with relapse.</p><p><b>Results:</b> The median total EPVS counts were 8 (IQR 4–9) at the initial brain MRI in patients with MOGAD. The number of total EPVS in patients with MOGAD was significantly positively correlated with CSF protein (<i>ρ</i> = 0.42, <i>p</i> = 0.044), EDSS (<i>r</i> = 0.74, <i>p</i> < 0.0001), QAlb (<i>ρ</i> = 0.48, <i>p</i> = 0.022), serum MOG-IgG titer (<i>ρ</i> = 0.48, <i>p</i> = 0.019), and CSF MOG-IgG titer (<i>ρ</i> = 0.46, <i>p</i> = 0.029). Univariate linear regression analysis indicated that CSF protein (<i>β</i> = 0.45, <i>p</i> = 0.03), EDSS scores (<i>β</i> = 0.6, <i>p</i> = 0.002), serum MOG-IgG titer (<i>β</i> = 0.51, <i>p</i> = 0.014), and CSF anti-MOG-IgG titer (<i>β</i> = 0.64, <i>p</i> = 0.001) were independent factors associated with EPVS counts. EDSS scores (<i>β</i> = 0.49, <i>p</i> = 0.002) and CSF MOG-IgG titer (<i>β</i> = 0.54, <i>p</i> = 0.001) were independent predictors associated with EPVS count in the multivariable linear regression model. Multivariable Cox regression analysis showed that the total number of EPVS was the only variable that revealed a significant effect on relapse (HR = 1.22, 95% CI 1.01–1.47, <i>p</i> = 0.04).</p><p><b>Conclusion:</b> In our cohort, we preliminary explored independent risk factors for increased EPVS. Moreover, EPVS might independently predict the risk of relapse in patients with MOGAD.</p>","PeriodicalId":6939,"journal":{"name":"Acta Neurologica Scandinavica","volume":"2025 1","pages":""},"PeriodicalIF":2.9000,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ane/8858684","citationCount":"0","resultStr":"{\"title\":\"Enlarged Perivascular Space Burden Predicts the Risk of Relapse in Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease Patients\",\"authors\":\"Ya Chen, Xia Zhang, Chengyu Pan, Zhongxiang Xu, Zucai Xu\",\"doi\":\"10.1155/ane/8858684\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><b>Background and Objectives:</b> Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) is an immune-mediated inflammatory demyelinating disease of the central nervous system, with a complex relapse mechanism involving various factors. The connection between enlarged perivascular spaces (EPVSs) and MOGAD is currently unclear. This study is aimed at exploring the risk factors associated with an increased number of EPVS in MOGAD patients and the association with relapse.</p><p><b>Methods:</b> A retrospective study was conducted on 23 patients with MOGAD. We analyzed the correlation between the number of EPVS and age, disease duration, cerebrospinal fluid (CSF) leukocytes, CSF protein, EDSS scores, albumin quotient, and MOG-IgG titer. We employed linear regression to assess the independent risk factors for the number of EPVS, and Cox regression was used to elucidate the independent factors associated with relapse.</p><p><b>Results:</b> The median total EPVS counts were 8 (IQR 4–9) at the initial brain MRI in patients with MOGAD. The number of total EPVS in patients with MOGAD was significantly positively correlated with CSF protein (<i>ρ</i> = 0.42, <i>p</i> = 0.044), EDSS (<i>r</i> = 0.74, <i>p</i> < 0.0001), QAlb (<i>ρ</i> = 0.48, <i>p</i> = 0.022), serum MOG-IgG titer (<i>ρ</i> = 0.48, <i>p</i> = 0.019), and CSF MOG-IgG titer (<i>ρ</i> = 0.46, <i>p</i> = 0.029). Univariate linear regression analysis indicated that CSF protein (<i>β</i> = 0.45, <i>p</i> = 0.03), EDSS scores (<i>β</i> = 0.6, <i>p</i> = 0.002), serum MOG-IgG titer (<i>β</i> = 0.51, <i>p</i> = 0.014), and CSF anti-MOG-IgG titer (<i>β</i> = 0.64, <i>p</i> = 0.001) were independent factors associated with EPVS counts. EDSS scores (<i>β</i> = 0.49, <i>p</i> = 0.002) and CSF MOG-IgG titer (<i>β</i> = 0.54, <i>p</i> = 0.001) were independent predictors associated with EPVS count in the multivariable linear regression model. Multivariable Cox regression analysis showed that the total number of EPVS was the only variable that revealed a significant effect on relapse (HR = 1.22, 95% CI 1.01–1.47, <i>p</i> = 0.04).</p><p><b>Conclusion:</b> In our cohort, we preliminary explored independent risk factors for increased EPVS. 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引用次数: 0
摘要
背景与目的：髓鞘少突胶质细胞糖蛋白抗体相关疾病（MOGAD）是一种免疫介导的中枢神经系统炎症性脱髓鞘疾病，其复发机制复杂，涉及多种因素。血管周围间隙增大（EPVSs）与MOGAD之间的关系目前尚不清楚。本研究旨在探讨与MOGAD患者EPVS数量增加相关的危险因素及其与复发的关系。方法：对23例MOGAD患者进行回顾性研究。我们分析了EPVS数量与年龄、病程、脑脊液（CSF）白细胞、CSF蛋白、EDSS评分、白蛋白商和MOG-IgG滴度的相关性。我们采用线性回归来评估EPVS数量的独立危险因素，并采用Cox回归来阐明与复发相关的独立因素。结果：MOGAD患者初始脑MRI时EPVS总数中位数为8 （IQR 4-9）。MOGAD患者总EPVS数与CSF蛋白（ρ = 0.42, p = 0.044）、EDSS (r = 0.74, p <；0.0001)、QAlb （ρ = 0.48, p = 0.022）、血清MOG-IgG滴度（ρ = 0.48, p = 0.019）和CSF MOG-IgG滴度（ρ = 0.46, p = 0.029）。单因素线性回归分析显示，CSF蛋白（β = 0.45, p = 0.03）、EDSS评分（β = 0.6, p = 0.002）、血清MOG-IgG滴度（β = 0.51, p = 0.014）和CSF抗MOG-IgG滴度（β = 0.64, p = 0.001）是影响EPVS计数的独立因素。在多元线性回归模型中，EDSS评分（β = 0.49, p = 0.002）和CSF MOG-IgG滴度（β = 0.54, p = 0.001）是与EPVS计数相关的独立预测因子。多变量Cox回归分析显示，EPVS总数是唯一对复发有显著影响的变量（HR = 1.22, 95% CI 1.01 ~ 1.47, p = 0.04）。结论：在我们的队列中，我们初步探索了EPVS升高的独立危险因素。此外，EPVS可以独立预测MOGAD患者的复发风险。
Enlarged Perivascular Space Burden Predicts the Risk of Relapse in Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease Patients
Background and Objectives: Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) is an immune-mediated inflammatory demyelinating disease of the central nervous system, with a complex relapse mechanism involving various factors. The connection between enlarged perivascular spaces (EPVSs) and MOGAD is currently unclear. This study is aimed at exploring the risk factors associated with an increased number of EPVS in MOGAD patients and the association with relapse.
Methods: A retrospective study was conducted on 23 patients with MOGAD. We analyzed the correlation between the number of EPVS and age, disease duration, cerebrospinal fluid (CSF) leukocytes, CSF protein, EDSS scores, albumin quotient, and MOG-IgG titer. We employed linear regression to assess the independent risk factors for the number of EPVS, and Cox regression was used to elucidate the independent factors associated with relapse.
Results: The median total EPVS counts were 8 (IQR 4–9) at the initial brain MRI in patients with MOGAD. The number of total EPVS in patients with MOGAD was significantly positively correlated with CSF protein (ρ = 0.42, p = 0.044), EDSS (r = 0.74, p < 0.0001), QAlb (ρ = 0.48, p = 0.022), serum MOG-IgG titer (ρ = 0.48, p = 0.019), and CSF MOG-IgG titer (ρ = 0.46, p = 0.029). Univariate linear regression analysis indicated that CSF protein (β = 0.45, p = 0.03), EDSS scores (β = 0.6, p = 0.002), serum MOG-IgG titer (β = 0.51, p = 0.014), and CSF anti-MOG-IgG titer (β = 0.64, p = 0.001) were independent factors associated with EPVS counts. EDSS scores (β = 0.49, p = 0.002) and CSF MOG-IgG titer (β = 0.54, p = 0.001) were independent predictors associated with EPVS count in the multivariable linear regression model. Multivariable Cox regression analysis showed that the total number of EPVS was the only variable that revealed a significant effect on relapse (HR = 1.22, 95% CI 1.01–1.47, p = 0.04).
Conclusion: In our cohort, we preliminary explored independent risk factors for increased EPVS. Moreover, EPVS might independently predict the risk of relapse in patients with MOGAD.
期刊介绍：
Acta Neurologica Scandinavica aims to publish manuscripts of a high scientific quality representing original clinical, diagnostic or experimental work in neuroscience. The journal''s scope is to act as an international forum for the dissemination of information advancing the science or practice of this subject area. Papers in English will be welcomed, especially those which bring new knowledge and observations from the application of therapies or techniques in the combating of a broad spectrum of neurological disease and neurodegenerative disorders. Relevant articles on the basic neurosciences will be published where they extend present understanding of such disorders. Priority will be given to review of topical subjects. Papers requiring rapid publication because of their significance and timeliness will be included as ''Clinical commentaries'' not exceeding two printed pages, as will ''Clinical commentaries'' of sufficient general interest. Debate within the speciality is encouraged in the form of ''Letters to the editor''. All submitted manuscripts falling within the overall scope of the journal will be assessed by suitably qualified referees.
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