莫扎特对大脑的影响——动脉瘤性蛛网膜下腔出血后听觉刺激对患者生理影响的初步研究

IF 2 Q3 NEUROSCIENCES

IBRO Neuroscience Reports Pub Date : 2025-06-21 DOI:10.1016/j.ibneur.2025.06.008

Nicolas Eden , Marius Marc-Daniel Mader , Jan Bremer , Jennifer Sauvigny , Jörn Grensemann , Marlene Fischer , Nils Schweingruber , Jens Gempt , Patrick Czorlich

{"title":"莫扎特对大脑的影响——动脉瘤性蛛网膜下腔出血后听觉刺激对患者生理影响的初步研究","authors":"Nicolas Eden , Marius Marc-Daniel Mader , Jan Bremer , Jennifer Sauvigny , Jörn Grensemann , Marlene Fischer , Nils Schweingruber , Jens Gempt , Patrick Czorlich","doi":"10.1016/j.ibneur.2025.06.008","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><div>Classical music influences human physiology, such as the cerebral blood flow velocity (CBFV), in healthy controls and during recovery from ischemic stroke. Aim of this prospective pilot-study was to investigate the effect of classical music on CBFV and other physiological parameters in patients suffering from aneurysmal subarachnoid hemorrhage (SAH).</div></div><div><h3>Methods</h3><div>Twenty patients with SAH were subjected to up to three interventions, in which the patients listened to <em>W. A. Mozart's Symphony No. 40 in G minor</em>. In parallel, CBFV in the right middle cerebral artery (MCA) was continuously measured using transcranial Doppler (TCD). TCD values were averaged per minute, normalized, and analyzed with a mixed-effects linear regression model. In addition, other physiological and laboratory parameters were evaluated.</div></div><div><h3>Results</h3><div>A total of 55 interventions were successfully carried out. The mixed-effects linear regression model revealed significant associations with both time (p < 0.001) and session (p = 0.002), specifically, with each minute of classical music played, there was a 0.3 % reduction in CBFV (95 % confidence interval (CI): 0.2–0.4 %). Heart rate (HR) and respiratory rate (RR) decreased by 0.1 % (95 % CI: −0.2–0.0 %; p = 0.043) 0.3 % (95 % CI: −0.6 % to −0.1 %; p = 0.001), respectively, per minute of exposure. Each additional session resulted in a reduction of HR by 4.3 % and RR by 22.3 % from the baseline at the start of the intervention to minute 25 (both p < 0.001).</div></div><div><h3>Conclusions</h3><div>Our pilot study shows only a very small effect of classical music such as Mozart's Symphony No. 40 in G <em>minor</em> in patients with SAH.</div></div>","PeriodicalId":13195,"journal":{"name":"IBRO Neuroscience Reports","volume":"19 ","pages":"Pages 198-204"},"PeriodicalIF":2.0000,"publicationDate":"2025-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Mozart for the brain - a pilot study on physiological effects of auditive stimulation in patients after aneurysmal subarachnoid hemorrhage\",\"authors\":\"Nicolas Eden , Marius Marc-Daniel Mader , Jan Bremer , Jennifer Sauvigny , Jörn Grensemann , Marlene Fischer , Nils Schweingruber , Jens Gempt , Patrick Czorlich\",\"doi\":\"10.1016/j.ibneur.2025.06.008\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background</h3><div>Classical music influences human physiology, such as the cerebral blood flow velocity (CBFV), in healthy controls and during recovery from ischemic stroke. Aim of this prospective pilot-study was to investigate the effect of classical music on CBFV and other physiological parameters in patients suffering from aneurysmal subarachnoid hemorrhage (SAH).</div></div><div><h3>Methods</h3><div>Twenty patients with SAH were subjected to up to three interventions, in which the patients listened to <em>W. A. Mozart's Symphony No. 40 in G minor</em>. In parallel, CBFV in the right middle cerebral artery (MCA) was continuously measured using transcranial Doppler (TCD). TCD values were averaged per minute, normalized, and analyzed with a mixed-effects linear regression model. In addition, other physiological and laboratory parameters were evaluated.</div></div><div><h3>Results</h3><div>A total of 55 interventions were successfully carried out. The mixed-effects linear regression model revealed significant associations with both time (p < 0.001) and session (p = 0.002), specifically, with each minute of classical music played, there was a 0.3 % reduction in CBFV (95 % confidence interval (CI): 0.2–0.4 %). Heart rate (HR) and respiratory rate (RR) decreased by 0.1 % (95 % CI: −0.2–0.0 %; p = 0.043) 0.3 % (95 % CI: −0.6 % to −0.1 %; p = 0.001), respectively, per minute of exposure. Each additional session resulted in a reduction of HR by 4.3 % and RR by 22.3 % from the baseline at the start of the intervention to minute 25 (both p < 0.001).</div></div><div><h3>Conclusions</h3><div>Our pilot study shows only a very small effect of classical music such as Mozart's Symphony No. 40 in G <em>minor</em> in patients with SAH.</div></div>\",\"PeriodicalId\":13195,\"journal\":{\"name\":\"IBRO Neuroscience Reports\",\"volume\":\"19 \",\"pages\":\"Pages 198-204\"},\"PeriodicalIF\":2.0000,\"publicationDate\":\"2025-06-21\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"IBRO Neuroscience Reports\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2667242125000909\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"NEUROSCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"IBRO Neuroscience Reports","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2667242125000909","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"NEUROSCIENCES","Score":null,"Total":0}

引用次数: 0

摘要

背景：古典音乐影响人体生理，如脑血流速度（CBFV），在健康对照和从缺血性中风恢复期。本前瞻性中试研究旨在探讨古典音乐对动脉瘤性蛛网膜下腔出血（SAH）患者CBFV及其他生理参数的影响。方法对20例SAH患者进行最多3次干预，分别为听莫扎特G小调第40号交响曲。同时，使用经颅多普勒（TCD）连续测量右侧大脑中动脉（MCA）的CBFV。TCD值平均每分钟，归一化，并分析与混合效应线性回归模型。此外，还对其他生理和实验室参数进行了评估。结果成功实施55项干预措施。混合效应线性回归模型显示，CBFV与时间（p <； 0.001）和时间（p = 0.002）都有显著关联，特别是，每播放一分钟古典音乐，CBFV减少0.3 %（95 %置信区间（CI）： 0.2-0.4 %）。心率（HR）和呼吸率（RR）下降0.1 %(95 % CI:−0.2-0.0 %；p = 0.043)0.3 %(95 %)CI:−0.6 %至−0.1 %；P = 0.001)，分别为每分钟暴露。从干预开始到第25分钟，每增加一次治疗，HR降低4.3 %，RR降低22.3% % （p均为 <； 0.001）。结论我们的初步研究表明，古典音乐如莫扎特的G小调第40交响曲对SAH患者的影响很小。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Mozart for the brain - a pilot study on physiological effects of auditive stimulation in patients after aneurysmal subarachnoid hemorrhage

Background

Classical music influences human physiology, such as the cerebral blood flow velocity (CBFV), in healthy controls and during recovery from ischemic stroke. Aim of this prospective pilot-study was to investigate the effect of classical music on CBFV and other physiological parameters in patients suffering from aneurysmal subarachnoid hemorrhage (SAH).

Methods

Twenty patients with SAH were subjected to up to three interventions, in which the patients listened to W. A. Mozart's Symphony No. 40 in G minor. In parallel, CBFV in the right middle cerebral artery (MCA) was continuously measured using transcranial Doppler (TCD). TCD values were averaged per minute, normalized, and analyzed with a mixed-effects linear regression model. In addition, other physiological and laboratory parameters were evaluated.

Results

A total of 55 interventions were successfully carried out. The mixed-effects linear regression model revealed significant associations with both time (p < 0.001) and session (p = 0.002), specifically, with each minute of classical music played, there was a 0.3 % reduction in CBFV (95 % confidence interval (CI): 0.2–0.4 %). Heart rate (HR) and respiratory rate (RR) decreased by 0.1 % (95 % CI: −0.2–0.0 %; p = 0.043) 0.3 % (95 % CI: −0.6 % to −0.1 %; p = 0.001), respectively, per minute of exposure. Each additional session resulted in a reduction of HR by 4.3 % and RR by 22.3 % from the baseline at the start of the intervention to minute 25 (both p < 0.001).