携带tet(M)基因的四环素耐药突变链球菌株的全基因组序列。

IF 2.6 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Oral Biosciences Pub Date : 2025-06-20 DOI:10.1016/j.job.2025.100679

Saki Nishihama , Yujin Suzuki , Tomoaki Shintani , Manami Tsunoi , Junzo Hisatsune , Yo Sugawara , Katsuhiro Takeda , Miki Kawada-Matsuo , Mikihito Kajiya , Motoyuki Sugai , Hideki Shiba , Hitoshi Komatsuzawa

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引用次数: 0

摘要

四环素类药物在牙科治疗中应用广泛。在此，我们首次报道了四环素耐药突变链球菌HSM45的基因组信息。方法：采用微量稀释法测定对四环素的药敏。测定HSM45的全基因组序列，并与公开的基因组数据进行比较。结果：HSM45对四环素耐药。四环素耐药基因tet(M)由一种广泛存在于革兰氏阳性菌中的共轭转座子Tn916携带。结论：本研究表明变形链球菌可以获得四环素耐药性，也可能是抗性基因水平转移的来源。

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Complete genome sequence of a tetracycline-resistant Streptococcus mutans strain carrying the tet(M) gene

Introduction

Tetracyclines are widely used in dental treatment. Here, we report the genomic information of the tetracycline-resistant Streptococcus mutans strain, HSM45, for the first time.

Methods

Susceptibility to tetracycline was determined using the microdilution method. The complete genome sequence of HSM45 was determined and compared with public genome data.

Results

HSM45 was resistant to tetracycline. The tetracycline resistance gene tet(M) was carried by Tn916, a conjugative transposon that is widely found in Gram-positive bacteria.