Constance Delaby, Aurélie Ladang, Jose Martinez-Yriarte, Chiara Zecca, Giancarlo Logroscino, Peter Körtvelyessy, Hayrettin Tumani, Piero Parchi, Isabelle Quadrio, Melanie Hart, Dorte Aalund Olsen, Daniel Alcolea, Kaj Blennow, Juan Fortea, Alberto Lleo, Alicia Algeciras-Schimnich, Xavier Ayrignac, Aurélie Bedel, Gustavo A. A. Santos, Wyllians Borelli, Elodie Bouaziz-Amar, Inês Baldeiras, Edith Bigot-Corbel, Maria Bjerke, Mercedes Carretero Perez, Tiziana Casoli, Tinatin Chabrashvili, Miles D. Chapman, Jessica Cusato, Erdinc Dursun, Anthony Fourier, Daniela Galimberti, Duygu Gezen-Ak, Brian A. Gordon, Julien Gouju, Silvia de las Heras Florez, Juanjo Hernandez Sanchez, Marina Herwerth, Daniele Imperiale, Flora Kaczorowski, Kensaku Kasuga, Ashvini Keshavan, Michael Khalil, Jens Kuhle, Christoph Leithner, Piotr Lewczuk, Franck Letournel, Magda Tsolaki, Guido Maria Giuffrè, Marie-Céline Blanc, Barbara Mroczko, Jose Enrique Martínez Rodríguez, Giulia Musso, Agnieszka Kulczynska-Przybik, Léonor Nogueira, Claire Paquet, Simone Baiardi, Lorenzo Gaetani, Lucilla Parnetti, Raquel Perez Garay, Koen Poesen, Muriel Quillard-Muraine, Enrique Rodriguez Borja, Susanna Schraen, Daniela Terracciano, Franziska Bachhuber, Steffen Halbgebauer, Socrates Tzartos, John Tzartos, Nadine Unterwalder, Lisa Vermunt, Cheryl L. Wellington, Henrik Zetterberg, Charlotte Teunissen, Sylvain Lehmann
{"title":"神经系统疾病中神经丝定量的临床应用和报告：全球综述","authors":"Constance Delaby, Aurélie Ladang, Jose Martinez-Yriarte, Chiara Zecca, Giancarlo Logroscino, Peter Körtvelyessy, Hayrettin Tumani, Piero Parchi, Isabelle Quadrio, Melanie Hart, Dorte Aalund Olsen, Daniel Alcolea, Kaj Blennow, Juan Fortea, Alberto Lleo, Alicia Algeciras-Schimnich, Xavier Ayrignac, Aurélie Bedel, Gustavo A. A. Santos, Wyllians Borelli, Elodie Bouaziz-Amar, Inês Baldeiras, Edith Bigot-Corbel, Maria Bjerke, Mercedes Carretero Perez, Tiziana Casoli, Tinatin Chabrashvili, Miles D. Chapman, Jessica Cusato, Erdinc Dursun, Anthony Fourier, Daniela Galimberti, Duygu Gezen-Ak, Brian A. Gordon, Julien Gouju, Silvia de las Heras Florez, Juanjo Hernandez Sanchez, Marina Herwerth, Daniele Imperiale, Flora Kaczorowski, Kensaku Kasuga, Ashvini Keshavan, Michael Khalil, Jens Kuhle, Christoph Leithner, Piotr Lewczuk, Franck Letournel, Magda Tsolaki, Guido Maria Giuffrè, Marie-Céline Blanc, Barbara Mroczko, Jose Enrique Martínez Rodríguez, Giulia Musso, Agnieszka Kulczynska-Przybik, Léonor Nogueira, Claire Paquet, Simone Baiardi, Lorenzo Gaetani, Lucilla Parnetti, Raquel Perez Garay, Koen Poesen, Muriel Quillard-Muraine, Enrique Rodriguez Borja, Susanna Schraen, Daniela Terracciano, Franziska Bachhuber, Steffen Halbgebauer, Socrates Tzartos, John Tzartos, Nadine Unterwalder, Lisa Vermunt, Cheryl L. Wellington, Henrik Zetterberg, Charlotte Teunissen, Sylvain Lehmann","doi":"10.1002/alz.70343","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> INTRODUCTION</h3>\n \n <p>Neurofilament light chain (NfL) quantification aids in diagnosing and predicting neurological disorders, but clinical and laboratory practices vary across centers. Differences in result interpretation and reporting further challenge test commutability. This study aimed to review the global analytical and post-analytical methods used for NfL measurement in routine clinical practice across different contexts.</p>\n </section>\n \n <section>\n \n <h3> METHODS</h3>\n \n <p>We established an international working group (WG) and distributed a survey to its members to gather information on context of use (COU), (pre) analytical methods, cutoff usage, as well as the interpretation and reporting of NfL measurements.</p>\n </section>\n \n <section>\n \n <h3> RESULTS</h3>\n \n <p>Among the centers, 63% measured NfL in cerebrospinal fluid (CSF), 87% in blood, and 53% in both. COU was widespread, with 50% defining pathological cutoffs based on publications and 42% considering age. Reporting was primarily done through numeric results (95%).</p>\n </section>\n \n <section>\n \n <h3> DISCUSSION</h3>\n \n <p>Harmonizing cutoffs, reporting, and interpretation across various clinical contexts will facilitate the incorporation of this biomarker into routine clinical practice.</p>\n </section>\n \n <section>\n \n <h3> Highlights</h3>\n \n <div>\n <ul>\n \n <li>Unique international overview of current analytical and post-analytical methods for neurofilament light chain (NfL) measurement in routine clinical practice.</li>\n \n <li>Tailored sheets for each neurological application.</li>\n \n <li>Strategies to harmonize cutoffs, reporting, and interpretation of NfL's measurement.</li>\n </ul>\n </div>\n </section>\n </div>","PeriodicalId":7471,"journal":{"name":"Alzheimer's & Dementia","volume":"21 6","pages":""},"PeriodicalIF":13.0000,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/alz.70343","citationCount":"0","resultStr":"{\"title\":\"Clinical use and reporting of neurofilament quantification in neurological disorders: A global overview\",\"authors\":\"Constance Delaby, Aurélie Ladang, Jose Martinez-Yriarte, Chiara Zecca, Giancarlo Logroscino, Peter Körtvelyessy, Hayrettin Tumani, Piero Parchi, Isabelle Quadrio, Melanie Hart, Dorte Aalund Olsen, Daniel Alcolea, Kaj Blennow, Juan Fortea, Alberto Lleo, Alicia Algeciras-Schimnich, Xavier Ayrignac, Aurélie Bedel, Gustavo A. A. Santos, Wyllians Borelli, Elodie Bouaziz-Amar, Inês Baldeiras, Edith Bigot-Corbel, Maria Bjerke, Mercedes Carretero Perez, Tiziana Casoli, Tinatin Chabrashvili, Miles D. Chapman, Jessica Cusato, Erdinc Dursun, Anthony Fourier, Daniela Galimberti, Duygu Gezen-Ak, Brian A. Gordon, Julien Gouju, Silvia de las Heras Florez, Juanjo Hernandez Sanchez, Marina Herwerth, Daniele Imperiale, Flora Kaczorowski, Kensaku Kasuga, Ashvini Keshavan, Michael Khalil, Jens Kuhle, Christoph Leithner, Piotr Lewczuk, Franck Letournel, Magda Tsolaki, Guido Maria Giuffrè, Marie-Céline Blanc, Barbara Mroczko, Jose Enrique Martínez Rodríguez, Giulia Musso, Agnieszka Kulczynska-Przybik, Léonor Nogueira, Claire Paquet, Simone Baiardi, Lorenzo Gaetani, Lucilla Parnetti, Raquel Perez Garay, Koen Poesen, Muriel Quillard-Muraine, Enrique Rodriguez Borja, Susanna Schraen, Daniela Terracciano, Franziska Bachhuber, Steffen Halbgebauer, Socrates Tzartos, John Tzartos, Nadine Unterwalder, Lisa Vermunt, Cheryl L. 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Reporting was primarily done through numeric results (95%).</p>\\n </section>\\n \\n <section>\\n \\n <h3> DISCUSSION</h3>\\n \\n <p>Harmonizing cutoffs, reporting, and interpretation across various clinical contexts will facilitate the incorporation of this biomarker into routine clinical practice.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Highlights</h3>\\n \\n <div>\\n <ul>\\n \\n <li>Unique international overview of current analytical and post-analytical methods for neurofilament light chain (NfL) measurement in routine clinical practice.</li>\\n \\n <li>Tailored sheets for each neurological application.</li>\\n \\n <li>Strategies to harmonize cutoffs, reporting, and interpretation of NfL's measurement.</li>\\n </ul>\\n </div>\\n </section>\\n </div>\",\"PeriodicalId\":7471,\"journal\":{\"name\":\"Alzheimer's & Dementia\",\"volume\":\"21 6\",\"pages\":\"\"},\"PeriodicalIF\":13.0000,\"publicationDate\":\"2025-06-23\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://onlinelibrary.wiley.com/doi/epdf/10.1002/alz.70343\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Alzheimer's & Dementia\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1002/alz.70343\",\"RegionNum\":1,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CLINICAL NEUROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Alzheimer's & Dementia","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/alz.70343","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
Clinical use and reporting of neurofilament quantification in neurological disorders: A global overview
INTRODUCTION
Neurofilament light chain (NfL) quantification aids in diagnosing and predicting neurological disorders, but clinical and laboratory practices vary across centers. Differences in result interpretation and reporting further challenge test commutability. This study aimed to review the global analytical and post-analytical methods used for NfL measurement in routine clinical practice across different contexts.
METHODS
We established an international working group (WG) and distributed a survey to its members to gather information on context of use (COU), (pre) analytical methods, cutoff usage, as well as the interpretation and reporting of NfL measurements.
RESULTS
Among the centers, 63% measured NfL in cerebrospinal fluid (CSF), 87% in blood, and 53% in both. COU was widespread, with 50% defining pathological cutoffs based on publications and 42% considering age. Reporting was primarily done through numeric results (95%).
DISCUSSION
Harmonizing cutoffs, reporting, and interpretation across various clinical contexts will facilitate the incorporation of this biomarker into routine clinical practice.
Highlights
Unique international overview of current analytical and post-analytical methods for neurofilament light chain (NfL) measurement in routine clinical practice.
Tailored sheets for each neurological application.
Strategies to harmonize cutoffs, reporting, and interpretation of NfL's measurement.
期刊介绍：
Alzheimer's & Dementia is a peer-reviewed journal that aims to bridge knowledge gaps in dementia research by covering the entire spectrum, from basic science to clinical trials to social and behavioral investigations. It provides a platform for rapid communication of new findings and ideas, optimal translation of research into practical applications, increasing knowledge across diverse disciplines for early detection, diagnosis, and intervention, and identifying promising new research directions. In July 2008, Alzheimer's & Dementia was accepted for indexing by MEDLINE, recognizing its scientific merit and contribution to Alzheimer's research.
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