含H8-BINOL†的手性金属-有机框架荧光传感器

IF 6.4 2区 材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY
Pattara Siripanich, Jierui Zhang, Martina Lessio and Carol Hua
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引用次数: 0

摘要

具有高对映体选择性的荧光手性化学传感器即使在低分析物浓度下也能以廉价、方便和快速的方式识别对映体。由于特定对映体的潜在有害副作用和疾病检测的潜力,对对映体系统的识别在制药和健康科学中具有重要意义。在这项工作中,第一个含有H8-BINOL的金属有机框架(MOFs)对天冬氨酸二甲酯的对映选择性比(er)为14.97和12.41,具有独特的非反向对映选择性。荧光行为与氨基酸及其衍生物的研究考虑了氨基酸侧链,极性和分子间相互作用。我们证明了额外的空间位阻与轴向手性的结合是增强荧光手性化学传感器对映体选择性的有力策略。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

A chiral metal–organic framework fluorescent sensor incorporating H8-BINOL†

A chiral metal–organic framework fluorescent sensor incorporating H8-BINOL†

Fluorescent chiral chemical sensors with high enantioselectivity enable the identification of enantiomers in an inexpensive, accessible, and rapid manner even at low analyte concentrations. The discrimination of enantiomeric systems is of high importance in pharmaceutical and health sciences due to potential deleterious side effects of specific enantiomers and the potential for disease detection. In this work, the first metal–organic frameworks (MOFs) containing H8-BINOL showed impressive enantioselective ratios (er) of 14.97 and 12.41 toward aspartic acid dimethyl ester exhibiting unique non-inverted enantioselectivity. The fluorescence behaviour with amino acids and their derivatives are examined with consideration of amino acid side chains, polarity, and intermolecular interactions. We demonstrate that the incorporation of additional steric hindrance with axial chirality is a powerful strategy for enhancing enantioselectivity in fluorescent chiral chemical sensors.

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来源期刊
Materials Chemistry Frontiers
Materials Chemistry Frontiers Materials Science-Materials Chemistry
CiteScore
12.00
自引率
2.90%
发文量
313
期刊介绍: Materials Chemistry Frontiers focuses on the synthesis and chemistry of exciting new materials, and the development of improved fabrication techniques. Characterisation and fundamental studies that are of broad appeal are also welcome. This is the ideal home for studies of a significant nature that further the development of organic, inorganic, composite and nano-materials.
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