中国四所高校大学生乙肝病毒血清阳性率及乙肝疫苗免疫应答

IF 4.5 3区医学 Q2 IMMUNOLOGY

Vaccine Pub Date : 2025-06-24 DOI:10.1016/j.vaccine.2025.127408

Yarong Song , Yongliang Feng , Feng Jiang , Xingyan Xu , Peijuan Yang , Minmin Liu , Lili Li , Chaobi Du , Huangyuan Li , Qiong Li , Jinge Qiao , Jing Shi , Le Yang , Tian Yao , Gongyuan Zhang , Jie Wang , Jie Li

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引用次数: 0

摘要

背景：没有有效免疫接种的人容易感染乙型肝炎病毒（HBV）。目前，对hbv易感成人没有适当的乙肝疫苗接种策略。我们旨在评估新生儿乙型肝炎免疫接种和大学生HBV标志物的长期效果，以探索适合高危人群的乙型肝炎疫苗接种策略。方法采用胶体金试纸对4所大学新生进行乙肝筛查。乙型肝炎表面抗原（HBsAg）阳性或乙型肝炎表面抗体（anti-HBs）阴性的受试者使用雅培试剂进一步确认。HBsAg和抗hbs双阴性者接种乙肝疫苗。结果3242名新生中，1604名（49.5%）HBsAg和anti-HBs均阴性，27名（0.8%）HBsAg阳性。在双阴性新生中，1263人接种了乙肝疫苗。第一次和第二次接种乙肝疫苗后，保护性抗- hbs血清转化率分别达到91.4%和98.5%。只有一名（0.1%）新生在第三次接种乙肝疫苗后仍呈抗- hbs阴性。此外，96.3%（104/108）的新生在第一次接种乙肝疫苗后未能实现保护性抗- hbs血清转化，他们的基线抗- hbs水平<；2个人/毫升。结论将乙肝疫苗纳入扩大免疫规划后，大学生乙肝表面抗原（HBsAg）患病率明显下降，但血清保护性抗- hbs阳性率仍然较低。对于抗hbs阴性的高危人群，建议接种乙肝疫苗或加强剂，对于抗hbs和hbs阳性的人群，建议接种两剂乙肝疫苗；2个人/毫升。

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The HBV seroprevalence and immune responses to hepatitis B vaccination among college students from four universities in China

Background

People without effective immunization are vulnerable to infection with hepatitis B virus (HBV). At present, there is no appropriate hepatitis B vaccination strategy for HBV-susceptible adults. We aim to assess the long-term effect of neonatal hepatitis B immunization and HBV markers among college students, so as to explore hepatitis B vaccination strategies suitable for high-risk group.

Methods

The enrolled freshmen from four universities were initially tested for hepatitis B screening using colloidal gold test strips. Subjects with positive hepatitis B surface antigen (HBsAg) or negative hepatitis B surface antibody (anti-HBs) were further confirmed using Abbott reagents. HBsAg and anti-HBs double negative individuals were administered hepatitis B vaccination.

Results

Using Abbott reagents, we confirmed that among 3242 enrolled freshmen, 1604 (49.5 %) were negative for both HBsAg and anti-HBs, and 27 (0.8 %) were HBsAg-positive. Among the double negative freshmen, 1263 received hepatitis B vaccination. After the first and second dose of hepatitis B vaccine, the protective anti-HBs seroconversion rates reached 91.4 % and 98.5 %, respectively. Only one (0.1 %) freshman was still negative for anti-HBs after the third dose of hepatitis B vaccine. In addition, 96.3 % (104/108) of the fresmen who failed to achieve protective anti-HBs seroconversion after the first dose of hepatitis B vaccine had a baseline anti-HBs level < 2 mIU/mL.

Conclusion

The HBsAg prevalence among college students has been significantly reduced after the integration of hepatitis B vaccine into Expanded Program on Immunization, but the rate of seroprotective anti-HBs among these students remains low. Hepatitis B vaccination or booster dose is advised for a high-risk group who have negative anti-HBs, and two doses of hepatitis B vaccine are advised for those with anti-HBs < 2 mIU/mL.

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来源期刊

Vaccine 医学-免疫学

CiteScore

8.70

自引率

5.50%

发文量

992

审稿时长

131 days

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