用于高性能SERS检测的三维柔性ZIF-8/Au NPs/微半球阵列衬底

IF 4.9 3区工程技术 Q2 ENGINEERING, ELECTRICAL & ELECTRONIC

Sensors and Actuators A-physical Pub Date : 2025-06-21 DOI:10.1016/j.sna.2025.116836

Yunqing Lu , Yongqiang Zhou , Di Cheng , Haiheng Ji , Ji Xu , Lei Zhang , Jin Wang

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引用次数: 0

摘要

在此，我们提出了一种用于高性能表面增强拉曼光谱（SERS）检测的三维（3D）柔性ZIF-8/Au纳米颗粒(NPs)/微半球阵列衬底。首先，将一个三维有序的微半球阵列结构从刚性蓝宝石衬底转移到柔性聚二甲基硅氧烷（PDMS）薄膜上。然后，通过界面自组装将Au NPs以微半球阵列的方式粘附在柔性PDMS薄膜上。3D微半球阵列为Au NPs提供了额外的涂层位点，以形成高密度的“热点”。随后，将一层ZIF-8自旋涂覆在基板上。ZIF-8的多孔性表现出预富集效应，富集了热点内的分析物。它们的结合有效地提高了衬底的性能。测定结果表明，该SERS底物的增强因子高达3.965 × 107，对4-ATP的检出限低至10−15 M.为了验证其实际应用，我们将该底物应用于污染了有毒水产养殖药剂孔雀石绿（MG）的实验室制备鱼皮样品的检测。这种底物能够在低至0.1 ppm（与环境监测和食品安全有关的水平）的浓度下清楚地识别MG。所制备的衬底具有快速实用SERS技术的巨大潜力。

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3D flexible ZIF-8/Au NPs/micro-hemisphere array substrate for high-performance SERS detection

Herein, we present a three-dimensional (3D) flexible ZIF-8/Au nanoparticles (NPs)/micro-hemisphere array substrate for high-performance surface-enhanced Raman spectroscopy (SERS) detection. First, a 3D ordered micro-hemisphere array structure was transferred from a rigid sapphire substrate to a flexible polydimethylsiloxane (PDMS) film. Then, Au NPs were adhered to the flexible PDMS film with the micro-hemisphere array via interfacial self-assembly. The 3D micro-hemisphere array offers additional coated sites for Au NPs to form high-density ‘hot spots’. Subsequently, a layer of ZIF-8 was spin coated onto the substrate. The porous nature of ZIF-8 exhibited a pre-concentration effect, enriching analytes within the hot spots. The combination of them improved the performance of the substrate effectively. The measurement results showed that this SERS substrate has an enhancement factor of up to 3.965 × 10⁷ and a detection limit for 4-ATP as low as 10⁻¹⁵ M. To demonstrate its practical application, the substrate was applied to the detection of malachite green (MG), a toxic aquaculture pharmaceutical agent, in laboratory-prepared fish skin samples contaminated with it. The substrate enabled the clear identification of MG at concentrations as low as 0.1 ppm, a level relevant to environmental monitoring and food safety. The prepared substrate has great potential for rapid practical SERS technologies.

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来源期刊

Sensors and Actuators A-physical 工程技术-工程：电子与电气

CiteScore

8.10

自引率

6.50%

发文量

630

审稿时长

49 days

期刊介绍： Sensors and Actuators A: Physical brings together multidisciplinary interests in one journal entirely devoted to disseminating information on all aspects of research and development of solid-state devices for transducing physical signals. Sensors and Actuators A: Physical regularly publishes original papers, letters to the Editors and from time to time invited review articles within the following device areas: • Fundamentals and Physics, such as: classification of effects, physical effects, measurement theory, modelling of sensors, measurement standards, measurement errors, units and constants, time and frequency measurement. Modeling papers should bring new modeling techniques to the field and be supported by experimental results. • Materials and their Processing, such as: piezoelectric materials, polymers, metal oxides, III-V and II-VI semiconductors, thick and thin films, optical glass fibres, amorphous, polycrystalline and monocrystalline silicon. • Optoelectronic sensors, such as: photovoltaic diodes, photoconductors, photodiodes, phototransistors, positron-sensitive photodetectors, optoisolators, photodiode arrays, charge-coupled devices, light-emitting diodes, injection lasers and liquid-crystal displays. • Mechanical sensors, such as: metallic, thin-film and semiconductor strain gauges, diffused silicon pressure sensors, silicon accelerometers, solid-state displacement transducers, piezo junction devices, piezoelectric field-effect transducers (PiFETs), tunnel-diode strain sensors, surface acoustic wave devices, silicon micromechanical switches, solid-state flow meters and electronic flow controllers. Etc...