合理研制无信号串扰检测中草药和生物体内二氧化硫和硫化氢的双通道荧光探针

IF 2.1 3区化学 Q2 CHEMISTRY, ORGANIC

Tetrahedron Pub Date : 2025-06-20 DOI:10.1016/j.tet.2025.134794

Chao Gao, Dan-Dan Cheng, Yang Liu, Ming-Lan Ma, Hai-Rong Cui

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引用次数: 0

摘要

开发一种同时检测中草药和生物体内二氧化硫和硫化氢的双功能荧光探针对人类健康至关重要。在这项研究中，我们提出了一种新的荧光探针TTP，它通过两个独立的荧光通道对SO2和H2S都表现出荧光开启响应。值得注意的是，该探针对SO2 （10 s）和H2S （60 s）的响应时间有显著差异，并且对一种物质的荧光响应不受另一种物质存在的影响，从而有效地消除了同时检测时的信号串扰问题。TTP探针与智能手机传感平台集成，实现各种中草药中SO2和H2S的方便、快速、定量、现场检测。此外，TTP还适用于活细胞和斑马鱼体内SO2和H2S水平的实时监测。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Rational development of dual-channel fluorescent probe for detecting SO2 and H2S without signal crosstalk in Chinese herbal medicines and living organisms

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Rational development of dual-channel fluorescent probe for detecting SO2 and H2S without signal crosstalk in Chinese herbal medicines and living organisms

The development of a bifunctional fluorescent probe for the simultaneous detection of SO₂ and H₂S in Chinese herbal medicines and living organisms is vital for human health. In this study, we present a novel fluorescent probe, TTP, which exhibits a fluorescence turn-on response to both SO₂ and H₂S through two independent fluorescent channels. Notably, this probe demonstrates a significant difference in response times for SO₂ (10 s) and H₂S (60 s), and the fluorescence response to one substance remains unaffected by the presence of the other, thus effectively eliminating the problem of signal crosstalk during the simultaneous detection. Integrating with a smartphone sensing platform, probe TTP realizes the convenient, rapid, quantitative, and on-site detection of SO₂ and H₂S in various Chinese herbal medicines. Additionally, TTP is suitable for the real-time monitoring of SO₂ and H₂S levels in living cells and zebrafish.

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来源期刊

Tetrahedron 化学-有机化学

CiteScore

3.90

自引率

4.80%

发文量

439

审稿时长

34 days

期刊介绍： Tetrahedron publishes full accounts of research having outstanding significance in the broad field of organic chemistry and its related disciplines, such as organic materials and bio-organic chemistry. Regular papers in Tetrahedron are expected to represent detailed accounts of an original study having substantially greater scope and details than that found in a communication, as published in Tetrahedron Letters. Tetrahedron also publishes thematic collections of papers as special issues and ''Reports'', commissioned in-depth reviews providing a comprehensive overview of a research area.