Crocetin，一种多功能类胡萝卜素：药理作用、分子机制和治疗潜力的新见解

IF 4.8 2区医学 Q2 IMMUNOLOGY

International immunopharmacology Pub Date : 2025-06-23 DOI:10.1016/j.intimp.2025.115125

Liping Liu , Fan Qiu , Dawei Wu , Tingyu Ding , Wenying Zhang , Yuelei Mao , Ke Xu , Fengying Diao , Huiying Yang , Yunjia Wu , Yuhang Zhang , Lei Zhang , Qin Wu

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引用次数: 0

摘要

植物源性天然产物已成为现代药物开发中不可或缺的资源，并在不同的疾病领域显示出显着的潜力。crocetin是一类具有代表性生物活性的类胡萝卜素，具有独特的多不饱和油酸结构，从藏红花柱头中提取，近年来的研究表明，crocetin具有多种药理作用和生物活性，包括抗肿瘤、保肝、镇痛、神经保护、心脏保护、抗辐射等保护作用。本综述综合了crocetin研究的最新进展，系统地评估了其多方面的药理作用、药代动力学特征和剂量依赖性毒性阈值。尤其值得注意的是，我们对crocetin疾病调节能力的机理的阐明，为crocetin药用价值的开发利用提供了良好的研究前景。

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Crocetin, a versatile carotenoid: Novel insights into pharmacological effects, molecular mechanisms, and therapeutic potential

Plant-derived natural products have emerged as indispensable resources in modern drug discovery, and demonstrated remarkable potential across diverse disease domains. As a representative bioactive carotenoid, crocetin features a unique polyunsaturated oleic acid structure, extracted from the stigma of Crocus sativus L. Recent studies have revealed that crocetin has multiple pharmacological effects and biological activities, including anti-tumor, hepatoprotective, analgesic, neuroprotective, cardioprotective, anti-radiation and other protective effects. The present comprehensive review synthesizes cutting-edge advances in crocetin research, systematically evaluating its multifaceted pharmacological actions, pharmacokinetic profiles and dose-dependent toxicity thresholds. Particularly noteworthy is our mechanistic elucidation of crocetin's disease-modulating capabilities, which offers promising research prospects for the development and utilization of the medicinal value of crocetin.

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来源期刊

International immunopharmacology 医学-免疫学

CiteScore

8.40

自引率

3.60%

发文量

935

审稿时长

53 days

期刊介绍： International Immunopharmacology is the primary vehicle for the publication of original research papers pertinent to the overlapping areas of immunology, pharmacology, cytokine biology, immunotherapy, immunopathology and immunotoxicology. Review articles that encompass these subjects are also welcome. The subject material appropriate for submission includes: • Clinical studies employing immunotherapy of any type including the use of: bacterial and chemical agents; thymic hormones, interferon, lymphokines, etc., in transplantation and diseases such as cancer, immunodeficiency, chronic infection and allergic, inflammatory or autoimmune disorders. • Studies on the mechanisms of action of these agents for specific parameters of immune competence as well as the overall clinical state. • Pre-clinical animal studies and in vitro studies on mechanisms of action with immunopotentiators, immunomodulators, immunoadjuvants and other pharmacological agents active on cells participating in immune or allergic responses. • Pharmacological compounds, microbial products and toxicological agents that affect the lymphoid system, and their mechanisms of action. • Agents that activate genes or modify transcription and translation within the immune response. • Substances activated, generated, or released through immunologic or related pathways that are pharmacologically active. • Production, function and regulation of cytokines and their receptors. • Classical pharmacological studies on the effects of chemokines and bioactive factors released during immunological reactions.