儿童注射减毒流感病毒活疫苗诱导血凝素茎反应性抗体的研究

IF 4.6 2区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

iScience Pub Date : 2025-06-13 DOI:10.1016/j.isci.2025.112893

Juan Manuel Carreño , Philip Meade , Na Fatimata Sogodogo , Kaori Sano , Johnstone Tcheou , Ariel Raskin , Gagandeep Singh , Miriam Fried , Madhumathi Loganathan , Benjamin Francis , Dominika Bielak , Ya Jankey Jagne , Hadijatou J. Salah , Florian Krammer , Thushan I. de Silva

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引用次数: 0

摘要

生命早期暴露于流感病毒可能会在免疫上留下血凝素群特异性印记，从而影响未来对感染或疫苗接种的反应。我们评估了儿童接种减毒流感病毒活疫苗（LAIV）的情况。使用两种含有不同H1N1成分的LAIV制剂（2016-17和2017-18）。观察到适度提高预先存在的血清柄反应滴度和增强功能性抗体依赖性细胞毒性活性（ADCC）。未接触甲型流感病毒的儿童的茎抗体诱导程度较低；然而，LAIV诱导了新生茎抗体，增加了1组（G1）和2组（G2）流感病毒血清阳性的儿童数量。2018年的LAIV配方含有更新的H1N1成分，可诱导具有强ADCC效应功能的较高茎反应性抗体对G1茎产生作用。血清中na反应性抗体及口服液中na分泌IgA （sIgA）未见明显变化。

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Induction of hemagglutinin stalk reactive antibodies by the administration of a live-attenuated influenza virus vaccine in children

Early life exposures to influenza viruses may imprint a hemagglutinin group-specific signature on immunity that impacts future responses to infection or vaccination. We assessed the administration of a live attenuated influenza virus (LAIV) vaccine in children. Two LAIV formulations (2016–17 and 2017–18) containing distinct H1N1 components were used. Modest boosting of pre-existing serum stalk reactive titers and enhancement of functional antibody-dependent cellular cytotoxicity activity (ADCC) was observed. The magnitude of stalk antibody induction in children naive to influenza A viruses was low; however, LAIV induced de novo stalk antibodies, increasing the number of children seropositive to both group 1 (G1) and group 2 (G2) influenza viruses. The 2018 LAIV formulation, containing an updated H1N1 component, induced higher stalk reactive antibodies with strong ADCC effector functions to the G1 stalk. No significant changes were detected in NA-reactive antibodies in serum or in stalk- or NA-secretory IgA (sIgA) in oral fluid.

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来源期刊

iScience Multidisciplinary-Multidisciplinary

CiteScore

7.20

自引率

1.70%

发文量

1972

审稿时长

6 weeks

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