水在脂质膜反应性中的作用：非平衡热力学的应用

IF 3.4 3区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Chemistry and Physics of Lipids Pub Date : 2025-06-17 DOI:10.1016/j.chemphyslip.2025.105514

E. Anibal Disalvo, Jimena del P. Cejas, Agustín González Paz, María de los A. Frías

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引用次数: 0

摘要

在间期模型框架内对脂质膜的现象学描述，其中膜是水合脂质的二维溶液，通过考虑水质间期的物理化学性质，可以使膜理论和Ling假说相容。膜受到机械应力，导致水合作用和成分的变化。这些条件影响不稳定活性水的数量倾向于对生物效应剂的反应。这种行为可以用不可逆过程的热力学方法恰当地描述，在不可逆过程中，膜是一个开放系统，由于邻近水溶液中的生物效应物而处于亚稳态，倾向于发生反应。根据这一分析，水合壳对生物效应物是惰性的，膜的反应是由多余的不稳定和渗透交换的水给予的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Role of water in the responsiveness of lipid membranes: Application of non-equilibrium thermodynamics

The phenomenological description of a lipid membrane within the frame of the interphase model in which membrane is a bidimensional solution of hydrated lipids allows to make compatible the membrane theory and Ling hypothesis by considering the physical chemical properties of the aqueous lipid interphase.

The membrane suffers mechanical stress inducing changes in hydration and changes in composition. These conditions affect the amount of labile active water propense to response to bioeffectors. This behavior is properly described with the approach of thermodynamic of irreversible processes in which the membrane is an open system and is in a metastable state propense to react due to bioeffectors in the adjacent aqueous solution. In terms of this analysis, the hydration shell is inert to bioeffectors and the response of the membrane is given by the excess of water that is labile and osmotically exchangeable.

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来源期刊

Chemistry and Physics of Lipids 生物-生化与分子生物学

CiteScore

7.60

自引率

2.90%

发文量

审稿时长

40 days

期刊介绍： Chemistry and Physics of Lipids publishes research papers and review articles on chemical and physical aspects of lipids with primary emphasis on the relationship of these properties to biological functions and to biomedical applications. Accordingly, the journal covers: advances in synthetic and analytical lipid methodology; mass-spectrometry of lipids; chemical and physical characterisation of isolated structures; thermodynamics, phase behaviour, topology and dynamics of lipid assemblies; physicochemical studies into lipid-lipid and lipid-protein interactions in lipoproteins and in natural and model membranes; movement of lipids within, across and between membranes; intracellular lipid transfer; structure-function relationships and the nature of lipid-derived second messengers; chemical, physical and functional alterations of lipids induced by free radicals; enzymatic and non-enzymatic mechanisms of lipid peroxidation in cells, tissues, biofluids; oxidative lipidomics; and the role of lipids in the regulation of membrane-dependent biological processes.